Acsl1 Gene Detail

Summary

• Symbol
  Acsl1
• Name
  acyl-CoA synthetase long-chain family member 1
• Synonyms
  Acas1, Facl2

• Feature Type
  protein coding gene
• IDs
  MGI:102797
  NCBI Gene: 14081
• Alliance
  gene page
• Transcription Start Sites
  73 TSS

Location &
Maps

• Sequence Map
  Chr8:46924214-46989088 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 8, 26.36 cM, cytoband B2
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  3586 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102797	protein coding gene	Chr8:46924074-46989088 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033588	protein coding gene	Chr8:45575162-45639653 (+)
A/J	MGP_AJ_G0033570	protein coding gene	Chr8:43810505-43887290 (+)
AKR/J	MGP_AKRJ_G0033495	protein coding gene	Chr8:45105487-45173458 (+)
BALB/cJ	MGP_BALBcJ_G0033567	protein coding gene	Chr8:43993956-44059496 (+)
C3H/HeJ	MGP_C3HHeJ_G0033276	protein coding gene	Chr8:45631798-45701399 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034083	protein coding gene	Chr8:47299711-47371100 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031032	protein coding gene	Chr8:40067991-40131954 (+)
CAST/EiJ	MGP_CASTEiJ_G0032602	protein coding gene	Chr8:45064093-45131327 (+)
CBA/J	MGP_CBAJ_G0033255	protein coding gene	Chr8:49188696-49257244 (+)
DBA/2J	MGP_DBA2J_G0033408	protein coding gene	Chr8:43620076-43684930 (+)
FVB/NJ	MGP_FVBNJ_G0033349	protein coding gene	Chr8:43094067-43160156 (+)
LP/J	MGP_LPJ_G0033496	protein coding gene	Chr8:45584227-45652354 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033394	protein coding gene	Chr8:49285994-49358332 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034101	protein coding gene	Chr8:45261574-45328001 (+)
PWK/PhJ	MGP_PWKPhJ_G0032310	protein coding gene	Chr8:43140823-43206834 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032146	protein coding gene	Chr8:44422601-44493542 (+)
WSB/EiJ	MGP_WSBEiJ_G0032718	protein coding gene	Chr8:45517199-45588696 (+)

Homology

• Human Ortholog
  ACSL1, acyl-CoA synthetase long chain family member 1

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  ACSL1, acyl-CoA synthetase long chain family member 1
  
• Synonyms
  ACS1, FACL1, FACL2, LACS, LACS1, LACS2
• Links
  HGNC:3569

  NCBI Gene ID: 2180

  neXtProt AC: NX_P33121

  UniProt: P33121

  
  
• Chr Location
  4q35.1; chr4:184755595-184826818 (-)  GRCh38

---

• MGI Vertebrate Homology
  Acsl1 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: ACSL1
• Gene Tree
  Acsl1
  

Human Diseases

• Diseases
  1 with Acsl1 mouse models

Human Disease

Mouse Models

cardiomyopathy

IDs

cardiomyopathy      

DOID:0050700
ICD10CM:I42
ICD9CM:425
ICD9CM:425.9
MESH:D009202
NCI:C34830
NCI:C53654
UMLS_CUI:C0033141
UMLS_CUI:C0036529
UMLS_CUI:C0878544

View 1 model

Mouse Models

Human Disease Modeled: cardiomyopathy

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Myh6-Acsl1)O7Jesc/0	FVB/N-Tg(Myh6-Acsl1)O7Jesc	J:68639	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  36 phenotypes from 4 alleles in 5 genetic backgrounds
  36 phenotype references
  

• All Mutations and Alleles
  13
• Chemically induced (other)
  1
• Endonuclease-mediated
  4
• Gene trapped
  3
• Targeted
  2
• Transgenic
  3
• Genomic Mutations
  1 involving Acsl1
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  37 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Liver acyl-CoA levels are reduced when this gene is conditionally knocked out in the liver. Impaired adaptive thermogenesis when this gene is conditionally knocked out in adipose tissue.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  98
• GO References
  16

Expression

• Assay Results
  1286
• Tissues
  154
• cDNA Data
  186
• Literature Summary
  14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase acsl1
  ZFIN acsl1a, acsl1b

Sequences &
Gene Models

• All Sequences
  87
• RefSeq
  23
• UniProt
  6
• CCDS
  CCDS22291.1

• Ensembl
  ENSMUSG00000018796 (Evidence)
• NCBI Gene
  14081

Representative Sequences			Length	Strain/Species
genomic	14081	NCBI Gene Model | MGI Sequence Detail	64875	C57BL/6J
transcript	NM_001424792	RefSeq | MGI Sequence Detail	4028	C57BL/6
polypeptide	P41216	UniProt | EBI | MGI Sequence Detail	699	Not Applicable

Protein
Information

• UniProt
  6 Sequences
• Protein Ontology
  PR:000003659 long-chain-fatty-acid--CoA ligase 1
  (term hierarchy)
• EC
  6.2.1.13, 6.2.1.15, 6.2.1.24, 6.2.1.3
• InterPro Domains
  IPR020845 AMP-binding, conserved site
  IPR000873 AMP-dependent synthetase/ligase domain
  IPR042099 ANL, N-terminal domain
  IPR045311 Long-chain fatty acid CoA synthetase, eukaryotic
• GlyGen
  P41216 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 192

  cDNA 186

  Primer pair 5

  Other 1

  
  

  Microarray probesets 6

Other
Accession IDs

MGD-MRK-1026, MGD-MRK-19705, MGI:87869

References

• Summaries
  All 95

  Developmental Gene Expression 14

  Diseases 1

  Gene Ontology 16

  Phenotypes 36
• Earliest
  J:2016 Weiner FR, et al., Regulation of gene expression by insulin and tumor necrosis factor alpha in 3T3-L1 cells. Modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1. J Biol Chem. 1991 Dec 15;266(35):23525-8
• Latest
  J:347662 Wright T, et al., Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1. Mol Cell. 2024 Apr 4;84(7):1338-1353.e8

TSS for Acsl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77199	Chr8:46924085-46924115 (+)	-114 bp
Tssr77200	Chr8:46924118-46924146 (+)	-82 bp
Tssr77201	Chr8:46924206-46924223 (+)	1 bp
Tssr77202	Chr8:46924730-46924741 (+)	522 bp
Tssr2561	Chr8:46924748-46924754 (+)	537 bp
Tssr77203	Chr8:46924756-46924822 (+)	575 bp
Tssr77204	Chr8:46924924-46924938 (+)	717 bp
Tssr77205	Chr8:46924973-46924990 (+)	768 bp
Tssr77206	Chr8:46925397-46925430 (+)	1,200 bp
Tssr77207	Chr8:46925434-46925449 (+)	1,228 bp
Tssr77208	Chr8:46927413-46927427 (+)	3,206 bp
Tssr77209	Chr8:46929594-46929600 (+)	5,383 bp
Tssr77210	Chr8:46931763-46931766 (+)	7,551 bp
Tssr77211	Chr8:46941417-46941452 (+)	17,221 bp
Tssr77212	Chr8:46941778-46941782 (+)	17,566 bp
Tssr77213	Chr8:46943956-46943967 (+)	19,748 bp
Tssr77214	Chr8:46943981-46943988 (+)	19,771 bp
Tssr77215	Chr8:46944002-46944003 (+)	19,789 bp
Tssr77216	Chr8:46944005-46944032 (+)	19,805 bp
Tssr77217	Chr8:46944039-46944044 (+)	19,828 bp
Tssr77218	Chr8:46944116-46944119 (+)	19,904 bp
Tssr77219	Chr8:46944123-46944157 (+)	19,926 bp
Tssr77220	Chr8:46944162-46944179 (+)	19,957 bp
Tssr77221	Chr8:46945398-46945424 (+)	21,197 bp
Tssr77222	Chr8:46945826-46945838 (+)	21,618 bp
Tssr77223	Chr8:46945894-46945905 (+)	21,686 bp
Tssr77224	Chr8:46945964-46945983 (+)	21,760 bp
Tssr77225	Chr8:46945990-46946025 (+)	21,794 bp
Tssr77226	Chr8:46956694-46956703 (+)	32,485 bp
Tssr77227	Chr8:46958675-46958756 (+)	34,502 bp
Tssr77228	Chr8:46959117-46959143 (+)	34,916 bp
Tssr77229	Chr8:46959178-46959188 (+)	34,969 bp
Tssr77230	Chr8:46960130-46960132 (+)	35,917 bp
Tssr77231	Chr8:46964435-46964453 (+)	40,230 bp
Tssr77232	Chr8:46964573-46964584 (+)	40,365 bp
Tssr77233	Chr8:46964796-46964808 (+)	40,588 bp
Tssr77234	Chr8:46965988-46965991 (+)	41,776 bp
Tssr77235	Chr8:46966327-46966340 (+)	42,120 bp
Tssr77236	Chr8:46966346-46966379 (+)	42,149 bp
Tssr77237	Chr8:46966382-46966401 (+)	42,178 bp
Tssr77238	Chr8:46971478-46971504 (+)	47,277 bp
Tssr77239	Chr8:46972258-46972269 (+)	48,050 bp
Tssr77240	Chr8:46974378-46974390 (+)	50,170 bp
Tssr77241	Chr8:46974531-46974541 (+)	50,322 bp
Tssr77242	Chr8:46974599-46974619 (+)	50,395 bp
Tssr77243	Chr8:46974637-46974642 (+)	50,426 bp
Tssr77244	Chr8:46974663-46974689 (+)	50,462 bp
Tssr77245	Chr8:46974695-46974702 (+)	50,485 bp
Tssr77246	Chr8:46974708-46974723 (+)	50,502 bp
Tssr77247	Chr8:46974732-46974746 (+)	50,525 bp
Tssr77248	Chr8:46974796-46974804 (+)	50,586 bp
Tssr77249	Chr8:46974830-46974841 (+)	50,622 bp
Tssr77250	Chr8:46974854-46974865 (+)	50,646 bp
Tssr77251	Chr8:46974922-46974933 (+)	50,714 bp
Tssr77252	Chr8:46979490-46979530 (+)	55,296 bp
Tssr77253	Chr8:46980236-46980282 (+)	56,045 bp
Tssr77254	Chr8:46981604-46981663 (+)	57,420 bp
Tssr77255	Chr8:46983413-46983442 (+)	59,214 bp
Tssr77256	Chr8:46984016-46984029 (+)	59,809 bp
Tssr77257	Chr8:46987289-46987313 (+)	63,087 bp
Tssr77258	Chr8:46987611-46987637 (+)	63,410 bp
Tssr77259	Chr8:46987646-46987659 (+)	63,439 bp
Tssr77260	Chr8:46987666-46987682 (+)	63,460 bp
Tssr77261	Chr8:46987722-46987733 (+)	63,514 bp
Tssr77262	Chr8:46987761-46987773 (+)	63,553 bp
Tssr77263	Chr8:46987777-46987788 (+)	63,569 bp
Tssr77264	Chr8:46987851-46987868 (+)	63,646 bp
Tssr77265	Chr8:46988001-46988039 (+)	63,806 bp
Tssr77266	Chr8:46988199-46988210 (+)	63,991 bp
Tssr77267	Chr8:46988239-46988259 (+)	64,035 bp
Tssr77268	Chr8:46988680-46988693 (+)	64,473 bp
Tssr77269	Chr8:46988714-46988726 (+)	64,506 bp
Tssr77270	Chr8:46988766-46988787 (+)	64,563 bp