Acsl1 Gene Detail

Summary

• Symbol
  Acsl1
• Name
  acyl-CoA synthetase long-chain family member 1
• Synonyms
  Acas1, Facl2

• Feature Type
  protein coding gene
• IDs
  MGI:102797
  NCBI Gene: 14081
• Alliance
  gene page
• Transcription Start Sites
  73 TSS

Location &
Maps

• Sequence Map
  Chr8:46924074-46989088 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 8, 26.36 cM, cytoband B2
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  428 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102797	protein coding gene	Chr8:46924074-46989088 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033588	protein coding gene	Chr8:45575162-45639653 (+)
A/J	MGP_AJ_G0033570	protein coding gene	Chr8:43810505-43887290 (+)
AKR/J	MGP_AKRJ_G0033495	protein coding gene	Chr8:45105487-45173458 (+)
BALB/cJ	MGP_BALBcJ_G0033567	protein coding gene	Chr8:43993956-44059496 (+)
C3H/HeJ	MGP_C3HHeJ_G0033276	protein coding gene	Chr8:45631798-45701399 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034083	protein coding gene	Chr8:47299711-47371100 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031032	protein coding gene	Chr8:40067991-40131954 (+)
CAST/EiJ	MGP_CASTEiJ_G0032602	protein coding gene	Chr8:45064093-45131327 (+)
CBA/J	MGP_CBAJ_G0033255	protein coding gene	Chr8:49188696-49257244 (+)
DBA/2J	MGP_DBA2J_G0033408	protein coding gene	Chr8:43620076-43684930 (+)
FVB/NJ	MGP_FVBNJ_G0033349	protein coding gene	Chr8:43094067-43160156 (+)
LP/J	MGP_LPJ_G0033496	protein coding gene	Chr8:45584227-45652354 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033394	protein coding gene	Chr8:49285994-49358332 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034101	protein coding gene	Chr8:45261574-45328001 (+)
PWK/PhJ	MGP_PWKPhJ_G0032310	protein coding gene	Chr8:43140823-43206834 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032146	protein coding gene	Chr8:44422601-44493542 (+)
WSB/EiJ	MGP_WSBEiJ_G0032718	protein coding gene	Chr8:45517199-45588696 (+)

Homology

• Human Ortholog
  ACSL1, acyl-CoA synthetase long chain family member 1

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  ACSL1, acyl-CoA synthetase long chain family member 1
  
• Synonyms
  ACS1, FACL1, FACL2, LACS, LACS1, LACS2
• Links
  HGNC:3569

  NCBI Gene ID: 2180

  neXtProt AC: NX_P33121

  UniProt: P33121

  
  
• Chr Location
  4q35.1; chr4:184755595-184826818 (-)  GRCh38

---

• Alliance of Genome Resources
  Acsl1 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: ACSL1
• Gene Tree
  Acsl1
  

Human Diseases

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  17 phenotypes from 1 allele in 2 genetic backgrounds
  19 phenotypes from multigenic genotypes
  34 phenotype references
  

• All Mutations and Alleles
  11
• Chemically induced (other)
  1
• Endonuclease-mediated
  2
• Gene trapped
  3
• Targeted
  2
• Transgenic
  3
• Genomic Mutations
  1 involving Acsl1
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  27 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Liver acyl-CoA levels are reduced when this gene is conditionally knocked out in the liver. Impaired adaptive thermogenesis when this gene is conditionally knocked out in adipose tissue.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  42
• GO References
  9

Expression

• Assay Results
  1252
• Tissues
  151
• cDNA Data
  186
• Literature Summary
  12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase acsl1
  ZFIN acsl1a, acsl1b

Interactions

• Acsl1 interacts with 257 markers (Mir7-2, Mir7b, Mir10a, ...) View All

Sequences &
Gene Models

• All Sequences
  83
• RefSeq
  19
• UniProt
  6
• CCDS
  CCDS22291.1

• Ensembl
  ENSMUSG00000018796 (Evidence)
• NCBI Gene
  14081

Representative Sequences			Length	Strain/Species
genomic	14081	NCBI Gene Model | MGI Sequence Detail	65015	C57BL/6J
transcript	NM_001302163	RefSeq | MGI Sequence Detail	3927	C57BL/6
polypeptide	P41216	UniProt | EBI | MGI Sequence Detail	699	Not Applicable

Protein
Information

• UniProt
  6 Sequences
• Protein Ontology
  PR:000003659 long-chain-fatty-acid--CoA ligase 1
  (term hierarchy)
• EC
  6.2.1.13, 6.2.1.15, 6.2.1.24, 6.2.1.3
• InterPro Domains
  IPR020845 AMP-binding, conserved site
  IPR025110 AMP-binding enzyme, C-terminal domain
  IPR000873 AMP-dependent synthetase/ligase domain
  IPR042099 ANL, N-terminal domain
  IPR045311 Long-chain fatty acid CoA synthetase, eukaryotic

Molecular
Reagents

• All nucleic 190

  cDNA 186

  Primer pair 3

  Other 1

  
  

  Microarray probesets 6

Other
Accession IDs

MGD-MRK-1026, MGD-MRK-19705, MGI:87869

References

• Summaries
  All 84

  Developmental Gene Expression 12

  Diseases 1

  Gene Ontology 9

  Phenotypes 34
• Earliest
  J:2016 Weiner FR, et al., Regulation of gene expression by insulin and tumor necrosis factor alpha in 3T3-L1 cells. Modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1. J Biol Chem. 1991 Dec 15;266(35):23525-8
• Latest
  J:333657 Dong H, et al., Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death in alcohol-induced steatohepatitis. Metabolism. 2022 Oct 28;138:155334

TSS for Acsl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77199	Chr8:46924085-46924115 (+)	26 bp
Tssr77200	Chr8:46924118-46924146 (+)	58 bp
Tssr77201	Chr8:46924206-46924223 (+)	141 bp
Tssr77202	Chr8:46924730-46924741 (+)	662 bp
Tssr2561	Chr8:46924748-46924754 (+)	677 bp
Tssr77203	Chr8:46924756-46924822 (+)	715 bp
Tssr77204	Chr8:46924924-46924938 (+)	857 bp
Tssr77205	Chr8:46924973-46924990 (+)	908 bp
Tssr77206	Chr8:46925397-46925430 (+)	1,340 bp
Tssr77207	Chr8:46925434-46925449 (+)	1,368 bp
Tssr77208	Chr8:46927413-46927427 (+)	3,346 bp
Tssr77209	Chr8:46929594-46929600 (+)	5,523 bp
Tssr77210	Chr8:46931763-46931766 (+)	7,691 bp
Tssr77211	Chr8:46941417-46941452 (+)	17,361 bp
Tssr77212	Chr8:46941778-46941782 (+)	17,706 bp
Tssr77213	Chr8:46943956-46943967 (+)	19,888 bp
Tssr77214	Chr8:46943981-46943988 (+)	19,911 bp
Tssr77215	Chr8:46944002-46944003 (+)	19,929 bp
Tssr77216	Chr8:46944005-46944032 (+)	19,945 bp
Tssr77217	Chr8:46944039-46944044 (+)	19,968 bp
Tssr77218	Chr8:46944116-46944119 (+)	20,044 bp
Tssr77219	Chr8:46944123-46944157 (+)	20,066 bp
Tssr77220	Chr8:46944162-46944179 (+)	20,097 bp
Tssr77221	Chr8:46945398-46945424 (+)	21,337 bp
Tssr77222	Chr8:46945826-46945838 (+)	21,758 bp
Tssr77223	Chr8:46945894-46945905 (+)	21,826 bp
Tssr77224	Chr8:46945964-46945983 (+)	21,900 bp
Tssr77225	Chr8:46945990-46946025 (+)	21,934 bp
Tssr77226	Chr8:46956694-46956703 (+)	32,625 bp
Tssr77227	Chr8:46958675-46958756 (+)	34,642 bp
Tssr77228	Chr8:46959117-46959143 (+)	35,056 bp
Tssr77229	Chr8:46959178-46959188 (+)	35,109 bp
Tssr77230	Chr8:46960130-46960132 (+)	36,057 bp
Tssr77231	Chr8:46964435-46964453 (+)	40,370 bp
Tssr77232	Chr8:46964573-46964584 (+)	40,505 bp
Tssr77233	Chr8:46964796-46964808 (+)	40,728 bp
Tssr77234	Chr8:46965988-46965991 (+)	41,916 bp
Tssr77235	Chr8:46966327-46966340 (+)	42,260 bp
Tssr77236	Chr8:46966346-46966379 (+)	42,289 bp
Tssr77237	Chr8:46966382-46966401 (+)	42,318 bp
Tssr77238	Chr8:46971478-46971504 (+)	47,417 bp
Tssr77239	Chr8:46972258-46972269 (+)	48,190 bp
Tssr77240	Chr8:46974378-46974390 (+)	50,310 bp
Tssr77241	Chr8:46974531-46974541 (+)	50,462 bp
Tssr77242	Chr8:46974599-46974619 (+)	50,535 bp
Tssr77243	Chr8:46974637-46974642 (+)	50,566 bp
Tssr77244	Chr8:46974663-46974689 (+)	50,602 bp
Tssr77245	Chr8:46974695-46974702 (+)	50,625 bp
Tssr77246	Chr8:46974708-46974723 (+)	50,642 bp
Tssr77247	Chr8:46974732-46974746 (+)	50,665 bp
Tssr77248	Chr8:46974796-46974804 (+)	50,726 bp
Tssr77249	Chr8:46974830-46974841 (+)	50,762 bp
Tssr77250	Chr8:46974854-46974865 (+)	50,786 bp
Tssr77251	Chr8:46974922-46974933 (+)	50,854 bp
Tssr77252	Chr8:46979490-46979530 (+)	55,436 bp
Tssr77253	Chr8:46980236-46980282 (+)	56,185 bp
Tssr77254	Chr8:46981604-46981663 (+)	57,560 bp
Tssr77255	Chr8:46983413-46983442 (+)	59,354 bp
Tssr77256	Chr8:46984016-46984029 (+)	59,949 bp
Tssr77257	Chr8:46987289-46987313 (+)	63,227 bp
Tssr77258	Chr8:46987611-46987637 (+)	63,550 bp
Tssr77259	Chr8:46987646-46987659 (+)	63,579 bp
Tssr77260	Chr8:46987666-46987682 (+)	63,600 bp
Tssr77261	Chr8:46987722-46987733 (+)	63,654 bp
Tssr77262	Chr8:46987761-46987773 (+)	63,693 bp
Tssr77263	Chr8:46987777-46987788 (+)	63,709 bp
Tssr77264	Chr8:46987851-46987868 (+)	63,786 bp
Tssr77265	Chr8:46988001-46988039 (+)	63,946 bp
Tssr77266	Chr8:46988199-46988210 (+)	64,131 bp
Tssr77267	Chr8:46988239-46988259 (+)	64,175 bp
Tssr77268	Chr8:46988680-46988693 (+)	64,613 bp
Tssr77269	Chr8:46988714-46988726 (+)	64,646 bp
Tssr77270	Chr8:46988766-46988787 (+)	64,703 bp