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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Acsl1
acyl-CoA synthetase long-chain family member 1
MGI:102797
36 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Acsl1tm1Rcol/Acsl1tm1Rcol
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA 		abnormal lipid homeostasis J:155714
normal adipose tissue phenotype J:155714
normal growth/size/body region phenotype J:155714
normal homeostasis/metabolism phenotype J:155714
Acsl1tm1Rcol/Acsl1tm1Rcol
Tg(Fabp4-cre)1Rev/0
involves: 129P2/OlaHsd * C57BL/6 		decreased circulating glycerol level J:162996
decreased fatty acid oxidation J:162996
decreased lipoprotein lipase activity J:162996
hyperlipidemia J:162996
hypoglycemia J:162996
impaired adaptive thermogenesis J:162996
increased body fat mass J:162996
increased circulating free fatty acids level J:162996
increased circulating triglyceride level J:162996
increased epididymal fat pad weight J:162996
increased fatty acids level J:162996
increased gonadal fat pad weight J:162996
increased triglyceride level J:162996
Tg(Myh6-Acsl1)J3Jesc/0
FVB/N-Tg(Myh6-Acsl1)J3Jesc 		congestive heart failure J:68639
decreased left ventricle systolic pressure J:68639
decreased ventricle muscle contractility J:68639
enlarged heart J:68639
heart left ventricle hypertrophy J:68639
thick ventricular wall J:68639
Tg(Myh6-Acsl1)M13Jesc/0
FVB/N-Tg(Myh6-Acsl1)M13Jesc 		congestive heart failure J:68639
decreased left ventricle systolic pressure J:68639
decreased ventricle muscle contractility J:68639
enlarged heart J:68639
heart left ventricle hypertrophy J:68639
premature death J:68639
thick ventricular wall J:68639
Tg(Myh6-Acsl1)O7Jesc/0
FVB/N-Tg(Myh6-Acsl1)O7Jesc 		abnormal breathing pattern J:68639
abnormal cardiovascular system physiology J:68639
abnormal lipid level J:68639
abnormal myocardial fiber morphology J:68639
abnormal phospholipid level J:68639
cardiac hypertrophy J:68639
cardiac interstitial fibrosis J:68639
cardiomyopathy J:68639
congestive heart failure J:68639
cyanosis J:68639
decreased left ventricle systolic pressure J:68639
decreased ventricle muscle contractility J:68639
enlarged heart J:68639
heart left ventricle hypertrophy J:68639
increased cardiac muscle triglyceride level J:68639
increased cardiomyocyte apoptosis J:68639
lethargy J:68639
premature death J:68639
thick ventricular wall J:68639
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory