Ppargc1b^tm1.1Javi
Targeted Allele Detail

Summary

• Symbol: Ppargc1b^tm1.1Javi
• Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta; targeted mutation 1.1, Josep A Villena
• MGI ID: MGI:5638648
• Synonyms: Ppargc1b^flox
• Gene: Ppargc1b Location: Chr18:61431207-61533502 bp, - strand Genetic Position: Chr18, 34.41 cM
• Alliance: Ppargc1b^tm1.1Javi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221221
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 3 and an FRT flanked pgk-neo cassette and loxP site were inserted in intron 5 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 4 and 5 floxed. (J:221221)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppargc1b Mutation: 56 strains or lines available

References

• Original: J:221221 Enguix N, et al., Mice lacking PGC-1beta in adipose tissues reveal a dissociation between mitochondrial dysfunction and insulin resistance. Mol Metab. 2013;2(3):215-26
• All: 4 reference(s)