All Phenotypes Brca1<tm2.1Cxd> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Brca1^tm2.1Cxd
targeted mutation 2.1, Chu-Xia Deng
MGI:2182470

Summary

14 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd	involves: 129S6/SvEvTac	MGI:2681549
hm2	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd	involves: 129S6/SvEvTac * C57BL/6	MGI:5494456
cn3	Brca1^tm2.1Cxd/Brca1^tm2Rjbr Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:5494458
cn4	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:5494460
cn5	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:5494461
cn6	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	MGI:5494459
cx7	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53bp1^tm1Jc/Trp53bp1^tm1Jc	involves: 129 * 129S6/SvEvTac	MGI:6739937
cx8	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Parp1^tm1Zqw/Parp1^tm1Zqw	involves: 129S2/SvPas * 129S6/SvEvTac	MGI:4360485
cx9	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm1Brd/Trp53⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd	MGI:4360339
cx10	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm1Brd/Trp53^tm1Brd	involves: 129S6/SvEvTac * 129S7/SvEvBrd	MGI:4360340
cx11	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Gadd45a^tm1Ajf/Gadd45a^tm1Ajf	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * C57BL/6	MGI:4360343
cx12	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm1Brd/Trp53⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB	MGI:4360341
cx13	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Cdkn1a^tm1Led/Cdkn1a^tm1Led	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB	MGI:4360342
cx14	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Shld1^em1Nus/Shld1^em1Nus	involves: 129S6/SvEvTac * C57BL/6NCrl	MGI:6739936

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (0 available); any Brca1 mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:70271 )

• no newborn homozygotes

embryo

decreased embryo size ( J:70271 )

• embryos normal or somewhat smaller in size between E9.5 and E11.5

• embryonic abnormalities begin to appear from E12.5 on

nervous system

abnormal nervous system morphology ( J:70271 )

• massive apoptosis in the nervous system

exencephaly ( J:70271 )

• in 10% of embryos

• half show sac-like structure of variable size on their back

cellular

increased fibroblast adhesion ( J:134494 )

• elevated adhesion rate for homozygous MEFs

abnormal cell death ( J:70271 )

• random cell death throughout the body

increased cellular sensitivity to gamma-irradiation ( J:81541 )

• thymocytes display increased sensitivity to induced apoptosis

increased apoptosis ( J:70271 )

• massive apoptosis in the nervous system

abnormal cell migration ( J:134494 )

• elevated invasive rates for MEFs using a Boyden chamber system

chromosomal instability ( J:307190 )

• PARPi-induced genome instability is increased in primary B cells

growth/size/body

decreased embryo size ( J:70271 )

• embryos normal or somewhat smaller in size between E9.5 and E11.5

• embryonic abnormalities begin to appear from E12.5 on

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (0 available); any Brca1 mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal centrosome morphology ( J:177853 )

• mouse embryonic fibroblasts exhibit centrosome amplification (cells with greater than 2 centrosomes)

decreased fibroblast proliferation ( J:177853 )

• of mouse embryonic fibroblasts

early cellular replicative senescence ( J:177853 )

• in mouse embryonic fibroblasts

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm2Rjbr Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (0 available); any Brca1 mutation (113 available)
Brca1^tm2Rjbr mutation (1 available); any Brca1 mutation (113 available)
Trp53^tm3Tyj mutation (2 available); any Trp53 mutation (238 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor latency ( J:177853 )

• 308 days compared with 380 days in Trp53^tm3Tyj Wap^tm1(cre)Arge double heterozygotes

• however, latency is similar to in Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (0 available); any Brca1 mutation (113 available)
Trp53^tm3Tyj mutation (2 available); any Trp53 mutation (238 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor latency ( J:177853 )

• 308 days compared with 380 days in Trp53^tm3Tyj Wap^tm1(cre)Arge double heterozygotes

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (0 available); any Brca1 mutation (113 available)
Brca1^tm3.1Rjbr mutation (1 available); any Brca1 mutation (113 available)
Trp53^tm3Tyj mutation (2 available); any Trp53 mutation (238 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor latency ( J:177853 )

• compared with Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm3Tyj/Trp53^tm3Tyj Wap^tm1(cre)Arge/Wap^tm1(cre)Arge

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (0 available); any Brca1 mutation (113 available)
Brca1^tm3.1Rjbr mutation (1 available); any Brca1 mutation (113 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:177853 )

N	• unlike in mice with Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Wap^tm1(cre)Arge/Wap⁺, mice remain tumor free over a 24-month observation period

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53bp1^tm1Jc/Trp53bp1^tm1Jc
Genetic Background	involves: 129 * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (0 available); any Brca1 mutation (113 available)
Trp53bp1^tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:307190 )

• mice show defects in IgG1 class switch recombination

hematopoietic system

abnormal class switch recombination ( J:307190 )

• mice show defects in IgG1 class switch recombination

cellular

chromosomal instability ( J:307190 )

• PARPi-induced genome instability is lower in primary B cells compared to that seen in homozygous Brca1 mutant cells but still increased compared to in wild-type cells

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Parp1^tm1Zqw/Parp1^tm1Zqw
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (0 available); any Brca1 mutation (113 available)
Parp1^tm1Zqw mutation (3 available); any Parp1 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:139260 )

• death occurs between E12.5 and E15.5

• no double homozygotes survive beyond E15.5

growth/size/body

decreased embryo size ( J:139260 )

• embryos are significantly smaller than normal

• development is apparently normal until death occurs between E12.5 and E15.5

nervous system

exencephaly ( J:139260 )

• in about 1/3 of homozygotes

• failure of anterior neural tube to close

• elevated apoptosis in the neuroepithelium

cellular

abnormal centrosome morphology ( J:139260 )

• 40% of MEFs with more than 2 centrosomes

abnormal chromosome morphology ( J:139260 )

• quadriradial stuctures in metaphase

aneuploidy ( J:139260 )

• 45% of MEFs display aneuploidy

decreased telomere length ( J:139260 )

• MEFs have shortened telomeres

decreased cell proliferation ( J:139260 )

• poor growth of MEFs derived at E14.5

embryo

decreased embryo size ( J:139260 )

• embryos are significantly smaller than normal

• development is apparently normal until death occurs between E12.5 and E15.5

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm1Brd/Trp53⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (0 available); any Brca1 mutation (113 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (238 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:70271 )

N	• survival to birth is normal

increased susceptibility to xenobiotic induced morbidity/mortality ( J:122899 )

• increased sensitivity to paraquat induced lethality

premature death ( J:81541 )

• die shortly after developing respiratory difficulty

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:70271 )

N	• normal mammary gland development

enlarged thymus ( J:81541 )

• seen on autopsy of mice that die prematurely

• enlarged thymus takes up most of the free space in the thorax

increased T cell derived lymphoma incidence ( J:81541 )

• develop in many mice

• lymphomas display a loss of heterozygocity at the Trp53 locus

• lymphoma cells display aneuploidy

• various chromosomal aberrations such as double minute chromosomes are greatly increased in frequency

increased mammary gland tumor incidence ( J:70271 )

• develop mammary gland tumors by 6-10 months of age

neoplasm

increased T cell derived lymphoma incidence ( J:81541 )

• develop in many mice

• lymphomas display a loss of heterozygocity at the Trp53 locus

• lymphoma cells display aneuploidy

• various chromosomal aberrations such as double minute chromosomes are greatly increased in frequency

increased mammary gland tumor incidence ( J:70271 )

• develop mammary gland tumors by 6-10 months of age

increased incidence of tumors by chemical induction ( J:122899 )

• increased incidence of esophageal tumors when treated with methyl N-amylnitrosamine

increased carcinoma incidence ( J:122899 )

• stomach and esophageal dysplasia and carcinomas at 8 month

• invasive carcinomas at 8-12 months

cellular

abnormal cell cycle checkpoint function ( J:70271 )

• partial or complete loss of G1 to S checkpoint control

increased embryonic tissue cell apoptosis ( J:70271 )

• in E14.5 embryos but still less than when both Trp53 alleles are normal

increased fibroblast proliferation ( J:70271 )

• embryonic fibroblasts (MEFs) grow better in culture than when both Trp53 alleles are normal

immune system

enlarged thymus ( J:81541 )

• seen on autopsy of mice that die prematurely

• enlarged thymus takes up most of the free space in the thorax

increased T cell derived lymphoma incidence ( J:81541 )

• develop in many mice

• lymphomas display a loss of heterozygocity at the Trp53 locus

• lymphoma cells display aneuploidy

• various chromosomal aberrations such as double minute chromosomes are greatly increased in frequency

respiratory system

respiratory distress ( J:81541 )

• develop breathing difficulties and become sick

digestive/alimentary system

abnormal esophageal epithelium morphology ( J:122899 )

• hyperkeratosis at 6 months

• increased cell proliferation in the basal layers

• hyperplasia and metaplasia at 6 months

• dysplasia and carcinomas at 8 months

abnormal stomach epithelium morphology ( J:122899 )

• hyperkeratosis of the forestomach at 6 months

• increased cell proliferation in the basal layers

• hyperplasia and metaplasia at 6 months

• dysplasia and carcinomas at 8 months

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:122899 )

• increased sensitivity to paraquat induced lethality

increased incidence of tumors by chemical induction ( J:122899 )

• increased incidence of esophageal tumors when treated with methyl N-amylnitrosamine

hematopoietic system

enlarged thymus ( J:81541 )

• seen on autopsy of mice that die prematurely

• enlarged thymus takes up most of the free space in the thorax

increased T cell derived lymphoma incidence ( J:81541 )

• develop in many mice

• lymphomas display a loss of heterozygocity at the Trp53 locus

• lymphoma cells display aneuploidy

• various chromosomal aberrations such as double minute chromosomes are greatly increased in frequency

embryo

increased embryonic tissue cell apoptosis ( J:70271 )

• in E14.5 embryos but still less than when both Trp53 alleles are normal

integument

increased mammary gland tumor incidence ( J:70271 )

• develop mammary gland tumors by 6-10 months of age

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm1Brd/Trp53^tm1Brd
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:81541 )

• lymphoma cells display polyploidy

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:81541 )

• lymphoma cells display polyploidy

immune system

increased T cell derived lymphoma incidence ( J:81541 )

• lymphoma cells display polyploidy

hematopoietic system

increased T cell derived lymphoma incidence ( J:81541 )

• lymphoma cells display polyploidy

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Gadd45a^tm1Ajf/Gadd45a^tm1Ajf
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (0 available); any Brca1 mutation (113 available)
Gadd45a^tm1Ajf mutation (1 available); any Gadd45a mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Exencephaly and growth retardation in Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Gadd45a^tm1Ajf/Gadd45a^tm1Ajf embryos

mortality/aging

prenatal lethality, complete penetrance ( J:91673 )

• no double homozygotes at birth

• embryos normal at E9.5-E10.5

• smaller than normal at E11.5 to E15.5 with many dying or dead

nervous system

exencephaly ( J:91673 )

• failure of anterior neural tube to close

• neuroepithelium of mutant brain fail to develop after E9.5

• higher rate of apoptosis in the neuroepithelium

cellular

abnormal centrosome morphology ( J:91673 )

• about 45% of MEFs have more than two centrosomes

• about 28% of cells in E9.5 embryos have more than two centrosomes

aneuploidy ( J:91673 )

• about 40% of MEFs are aneuploid at passage 2

embryo

embryonic growth retardation ( J:91673 )

growth/size/body

embryonic growth retardation ( J:91673 )

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm1Brd/Trp53⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:81559 )

• 30% of males die of lymphoma by 7 months of age

• most males are dead by 12 months of age

premature aging ( J:81559 )

• 8 month and older males develop aging phenotypes

• aging phenotypes also seen in female mice

growth/size/body

decreased body weight ( J:81559 )

• greatly reduced body weight

skeleton

kyphosis ( J:81559 )

abnormal bone structure ( J:81559 )

decreased compact bone thickness ( J:81559 )

abnormal trabecular bone morphology ( J:81559 )

• loss of trabecular bone

osteoporosis ( J:81559 )

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:81559 )

• reduced anaesthetic stress tolerance

impaired wound healing ( J:81559 )

• reduced re-epithelialization at wound edges

adipose tissue

decreased subcutaneous adipose tissue amount ( J:81559 )

• reduced subcutaneous adipose tissue

decreased total body fat amount ( J:81559 )

• adipose tissue generally reduced

muscle

muscular atrophy ( J:81559 )

neoplasm

increased tumor incidence ( J:81559 )

• increased tumorigenesis in females

reproductive system

meiotic nondisjunction ( J:82308 )

• homologous chromosomes synapse but fail to separate

increased male germ cell apoptosis ( J:82308 )

• apoptotic spermatocytes in seminiferous tubules increased at 16 and 21 days of age relative to controls

small testis ( J:82308 )

• significantly smaller than controls at 16 days of age

abnormal spermatogenesis ( J:82308 )

azoospermia ( J:82308 )

• males over six weeks of age lack spermatozoa in the testes

• testes histologically normal at 10 days

decreased spermatid number ( J:82308 )

• no spermatids present at 21 days of age

abnormal male meiosis ( J:82308 )

• no diplotene stage spermatocytes detected at 16 days of age

arrest of male meiosis ( J:82308 )

• spermatogenesis does not progress beyond meiosis I

• spermatocytes do not pass through pachytene stage

endocrine/exocrine glands

small testis ( J:82308 )

• significantly smaller than controls at 16 days of age

cellular

azoospermia ( J:82308 )

• males over six weeks of age lack spermatozoa in the testes

• testes histologically normal at 10 days

decreased spermatid number ( J:82308 )

• no spermatids present at 21 days of age

abnormal male meiosis ( J:82308 )

• no diplotene stage spermatocytes detected at 16 days of age

arrest of male meiosis ( J:82308 )

• spermatogenesis does not progress beyond meiosis I

• spermatocytes do not pass through pachytene stage

meiotic nondisjunction ( J:82308 )

• homologous chromosomes synapse but fail to separate

increased male germ cell apoptosis ( J:82308 )

• apoptotic spermatocytes in seminiferous tubules increased at 16 and 21 days of age relative to controls

decreased cell proliferation ( J:81559 )

• of MEFs

integument

decreased subcutaneous adipose tissue amount ( J:81559 )

• reduced subcutaneous adipose tissue

delayed hair regrowth ( J:81559 )

• reduced hair regeneration

thin dermal layer ( J:81559 )

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Cdkn1a^tm1Led/Cdkn1a^tm1Led
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (0 available); any Brca1 mutation (113 available)
Cdkn1a^tm1Led mutation (1 available); any Cdkn1a mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:81559 )

• improved embryonic survival

• death within 24 hours of birth

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Shld1^em1Nus/Shld1^em1Nus
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (0 available); any Brca1 mutation (113 available)
Shld1^em1Nus mutation (0 available); any Shld1 mutation (77 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:307190 )

• mice show defects in IgG1 class switch recombination

hematopoietic system

abnormal class switch recombination ( J:307190 )

• mice show defects in IgG1 class switch recombination

cellular

chromosomal instability ( J:307190 )

• PARPi-induced genome instability is lower in primary B cells compared to that seen in homozygous Brca1 mutant cells but still increased compared to in wild-type cells

mortality/aging

mortality/aging ( J:307190 )

N	• the expected Mendelian ratio of mice are obtained, indicating rescue of the embryonic lethality of homozygous Brca1 mutants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24