Phenotype Image Detail

Image

Caption

Embryo Analysis. A: E9.5 Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Gadd45a^tm1Ajf/Gadd45a^tm1Ajf (left) and control Brca1^tm2.1Cxd/Brac1⁺ Gadd45a^tm1Ajf/Gadd45a^tm1Ajf (right) embryos. The double homozygous mutant embryo was smaller and exhibited an open neural tube (arrow). B: Placement of the mutant embryo in A at a different angle to show that the entire neural tube was open. C and D: E10.5 mutant embryos (left) showing growth retardation and open neural tubes (arrows). The control embryos (right) were normal. E: Whole-mount in situ hybridzation image of an E10.5 double homozygous mutant embryo showing Otx2 expression, revealing that the unclosed region extended to the hindbrain (arrow). F: E13.5 double homozygous mutant (arrow), Brca1^tm2.1Cxd/Brca1^tm2.1Cxd (Br^delta/delta), and wild-type (WT) embryos. G: An E15.5 double homozygous mutant embryo showing exencephaly. Bar= 625 um for A, 327 um for B, 1.2 mm for C and D, 393 um for E, 3.3 mm for F, and 2.37 mm for G.

This image is from Wang X, J Biol Chem 2004 Jul 9;279(28):29606-14 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:91673

Associated
Alleles

Symbol	Name
Brca1^tm2.1Cxd	breast cancer 1, early onset; targeted mutation 2.1, Chu-Xia Deng
Gadd45a^tm1Ajf	growth arrest and DNA-damage-inducible 45 alpha; targeted mutation 1, Albert J Fornace

Associated
Genotypes

Allelic Composition	Genetic Background
Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Gadd45a^tm1Ajf/Gadd45a^tm1Ajf	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * C57BL/6

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