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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Msh2tm1Htr
targeted mutation 1, Hein Te Riele
MGI:1858055
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Msh2tm1Htr/Msh2tm1Htr either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * FVB) MGI:2183310
hm2
 		Msh2tm1Htr/Msh2tm1Htr involves: 129P2/OlaHsd MGI:4429602
hm3
 		Msh2tm1Htr/Msh2tm1Htr involves: 129P2/OlaHsd * FVB MGI:4429608
ht4
 		Msh2tm1Htr/Msh2+ involves: 129P2/OlaHsd MGI:4429607
cx5
 		Msh2tm1Htr/Msh2tm1Htr
Pcnatm1Jcbs/Pcnatm1Jcbs 		involves: 129P2/OlaHsd MGI:4429640
cx6
 		Hrhr/Hrhr
Msh2tm1Htr/Msh2tm1Htr 		involves: 129P2/OlaHsd MGI:4429630
cx7
 		Htttm5Mem/Htt+
Msh2tm1Htr/Msh2tm1Htr 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1 * FVB/N MGI:4429638
cx8
 		ApcMin/Apc+
Msh2tm1Htr/Msh2tm1Htr 		involves: 129P2/OlaHsd * BALB/c * C57BL/6J MGI:4429611
cx9
 		B4galnt2a/B4galnt2b
Msh2tm1Htr/Msh2tm1Htr 		involves: 129P2/OlaHsd * BALB/c * SWR MGI:4429627
cx10
 		Msh2tm1Htr/Msh2tm1Htr
Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu
Ungtm1Tld/Ungtm1Tld 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N MGI:5505262
cx11
 		Msh2tm1Htr/Msh2tm1Htr
Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu
Ungtm1Tld/Ungtm1Tld 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N MGI:5507886
cx12
 		Hrhr/Hrhr
Msh2tm1Htr/Msh2tm1Htr
Xpatm1Tnka/Xpatm1Tnka 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4429631
cx13
 		Msh2tm1Htr/Msh2tm1Htr
Tap1tm1Hpl/Tap1tm1Hpl 		involves: 129P2/OlaHsd * FVB MGI:4429609


Genotype
MGI:2183310
hm1
Allelic
Composition		 Msh2tm1Htr/Msh2tm1Htr
Genetic
Background		 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:27469 )
• 30% of homozygous animals developed metastasizing lymphomas of T cell origin, peaking at 2 months of age

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:27469 )
• 30% of homozygous animals developed metastasizing lymphomas of T cell origin, peaking at 2 months of age

immune system
increased T cell derived lymphoma incidence ( J:27469 )
• 30% of homozygous animals developed metastasizing lymphomas of T cell origin, peaking at 2 months of age

hematopoietic system
increased T cell derived lymphoma incidence ( J:27469 )
• 30% of homozygous animals developed metastasizing lymphomas of T cell origin, peaking at 2 months of age




Genotype
MGI:4429602
hm2
Allelic
Composition		 Msh2tm1Htr/Msh2tm1Htr
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:45433 )
• two-third of mice die by 19.5 weeks
• Background Sensitivity: mice on a pure 129P2/OlaHsd background die sooner than those on a mixed 129P2/OlaHsd and FVB background

immune system
immune system phenotype ( J:47993 )
N
• somatic hypermutation rates in memory B cells are normal
abnormal class switch recombination ( J:80893 )
• LPS-stimulated blasting B cells exhibit a 7-fold reduction in switching to IgG3 compared with similarly treated wild-type mice
• however, IgM response to LPS treatment is normal
abnormal somatic hypermutation frequency ( J:155454 )
• mice exhibit a 61% reduction in total mutation frequency in germinal center B cell compared with wild-type mice
decreased IgG1 level ( J:80893 )
• following NP-ficcoll or LPS plus IL4 stimulation
decreased IgG3 level ( J:80893 )
• following NP-ficcoll or LPS stimulation
abnormal inflammatory response ( J:80893 )
• LPS-stimulated blasting B cells exhibit a 7-fold reduction in switching to IgG3 compared with similarly treated wild-type mice
• however, the proportion of B cells that blasted in response to LPS is normal

neoplasm
increased tumor incidence ( J:45433 )
• mice that survive beyond 19.5 weeks exhibit a multitude of tumor types (lymphoid, erythroid, intestine, skin, sebaceous gland, brain, intestine, and hereditary nonpolyposis colorectal cancer)
increased gastrointestinal tumor incidence ( J:45433 )
• all mice that survive beyond 30 weeks develop HNPCC (hereditary nonpolyposis colorectal cancer)
increased skin tumor incidence ( J:45433 )
• in mice that survive beyond 19.5 weeks
increased lymphoma incidence ( J:45433 )
• 80% of mice that die prior to 19.5 weeks of age present with a lymphoid tumor, mostly of T cell origin
increased brain tumor incidence ( J:45433 )
• in 13% of mice that survive beyond 19.5 weeks

hematopoietic system
abnormal class switch recombination ( J:80893 )
• LPS-stimulated blasting B cells exhibit a 7-fold reduction in switching to IgG3 compared with similarly treated wild-type mice
• however, IgM response to LPS treatment is normal
abnormal somatic hypermutation frequency ( J:155454 )
• mice exhibit a 61% reduction in total mutation frequency in germinal center B cell compared with wild-type mice
decreased IgG1 level ( J:80893 )
• following NP-ficcoll or LPS plus IL4 stimulation
decreased IgG3 level ( J:80893 )
• following NP-ficcoll or LPS stimulation

integument
increased skin tumor incidence ( J:45433 )
• in mice that survive beyond 19.5 weeks

endocrine/exocrine glands

nervous system
increased brain tumor incidence ( J:45433 )
• in 13% of mice that survive beyond 19.5 weeks

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:45433 )
• all mice that survive beyond 30 weeks develop HNPCC (hereditary nonpolyposis colorectal cancer)

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Lynch syndrome DOID:3883 OMIM:PS120435
 J:45433




Genotype
MGI:4429608
hm3
Allelic
Composition		 Msh2tm1Htr/Msh2tm1Htr
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:45433 )
• two-third of mice die by 30 weeks
• Background Sensitivity: mice on a mixed 129P2/OlaHsd and FVB background die sooner than those on a pure 129P2/OlaHsd background

neoplasm
increased tumor incidence ( J:45433 )
• mice that survive beyond 30 weeks exhibit a multitude of tumors types (lymphoid, erythroid, intestine, skin, uterus, mammary gland, lung, intestine, sebaceous gland, and hereditary nonpolyposis colorectal cancer)
increased gastrointestinal tumor incidence ( J:45433 )
• 62% of mice that survive beyond 30 weeks develop Hereditary Nonpolyposis Colon Cancer (HNPCC) tumors
increased mammary gland tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks
increased incidence of tumors by chemical induction ( J:45433 )
• all ENU-treated mice develop lymphomas by 14 weeks of age compared with 25% of similarly treated wild-type mice by 13 and 27 weeks
increased skin tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks
increased lymphoma incidence ( J:45433 )
• 80% of mice that die prior to 30 weeks of age present with a lymphoid tumor, mostly of T cell origin
• all ENU-treated mice develop lymphomas by 14 weeks of age compared with 25% of similarly treated wild-type mice by 13 and 27 weeks
increased uterus tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks
increased lung tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:45433 )
• all ENU-treated mice develop lymphomas by 14 weeks of age compared with 25% of similarly treated wild-type mice by 13 and 27 weeks

integument
increased mammary gland tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks
increased skin tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks

reproductive system
increased uterus tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks

respiratory system
increased lung tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:45433 )
• 62% of mice that survive beyond 30 weeks develop Hereditary Nonpolyposis Colon Cancer (HNPCC) tumors

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks

hematopoietic system

immune system




Genotype
MGI:4429607
ht4
Allelic
Composition		 Msh2tm1Htr/Msh2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:45433 )
• mice die within 100 weeks

neoplasm
increased tumor incidence ( J:45433 )
• mice develop more tumors than wild-type mice including lung, liver, mammary gland, skin, uterus, hemangiosarcoma, Schwann cell, teratocarcinoma, osteosarcoma, adrenal gland, and bladder tumors

integument

liver/biliary system

respiratory system

endocrine/exocrine glands

reproductive system

skeleton




Genotype
MGI:4429640
cx5
Allelic
Composition		 Msh2tm1Htr/Msh2tm1Htr
Pcnatm1Jcbs/Pcnatm1Jcbs
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
Pcnatm1Jcbs mutation (0 available); any Pcna mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal somatic hypermutation frequency ( J:155454 )
• mice exhibit a reduction in total mutation frequency in germinal center B cell compared with wild-type mice that is similar to that observed in Msh2tm1Htr homozygotes

hematopoietic system
abnormal somatic hypermutation frequency ( J:155454 )
• mice exhibit a reduction in total mutation frequency in germinal center B cell compared with wild-type mice that is similar to that observed in Msh2tm1Htr homozygotes




Genotype
MGI:4429630
cx6
Allelic
Composition		 Hrhr/Hrhr
Msh2tm1Htr/Msh2tm1Htr
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrhr mutation (17 available); any Hr mutation (86 available)
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased mortality induced by ionizing radiation ( J:79734 )
• 20% of mice die 15 weeks after UVB-irradiation unlike similarly treated wild-type mice
premature death ( J:79734 )
• 20% of mice die of lymphomas by 20 weeks of age

neoplasm
increased skin tumor incidence ( J:79734 )
• by 52 weeks, 81% of mice develop skin tumors
• 18 weeks after UVB-irradiation mice develop skin tumors compared with 23 weeks for similarly treated wild-type mice
increased skin papilloma incidence ( J:79734 )
• 23% of spontaneous skin tumors are papillomas
increased skin squamous cell carcinoma incidence ( J:79734 )
• 77% of spontaneous skin tumors are squamous cell carcinomas
increased lymphoma incidence ( J:79734 )
• 20% of mice die of lymphomas by 20 weeks of age
• 15 weeks after UVB-irradiation, mice develop lymphomas unlike similarly treated wild-type mice
increased incidence of tumors by UV-induction ( J:79734 )
• 15 weeks after UVB-irradiation, mice develop lymphomas unlike similarly treated wild-type mice
• 18 weeks after UVB-irradiation mice develop skin tumors compared with 23 weeks for similarly treated wild-type mice
• UVB-irradiated mice do not remain tumor free as long as similarly treated wild-type mice

integument
increased skin tumor incidence ( J:79734 )
• by 52 weeks, 81% of mice develop skin tumors
• 18 weeks after UVB-irradiation mice develop skin tumors compared with 23 weeks for similarly treated wild-type mice
increased skin papilloma incidence ( J:79734 )
• 23% of spontaneous skin tumors are papillomas
increased skin squamous cell carcinoma incidence ( J:79734 )
• 77% of spontaneous skin tumors are squamous cell carcinomas

homeostasis/metabolism
increased mortality induced by ionizing radiation ( J:79734 )
• 20% of mice die 15 weeks after UVB-irradiation unlike similarly treated wild-type mice




Genotype
MGI:4429638
cx7
Allelic
Composition		 Htttm5Mem/Htt+
Msh2tm1Htr/Msh2tm1Htr
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htttm5Mem mutation (2 available); any Htt mutation (176 available)
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
neuronal intranuclear inclusions ( J:81666 )
• intranuclear accumulation of mutant huntingtin is delayed 5 months compared to in Htttm5Mem heterozygotes




Genotype
MGI:4429611
cx8
Allelic
Composition		 ApcMin/Apc+
Msh2tm1Htr/Msh2tm1Htr
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (151 available)
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:45433 )
• survival is reduced 4-fold compared with ApcMin heterozygotes
• all mice die within 5 months

neoplasm
increased gastrointestinal tumor incidence ( J:45433 )
• mice have an 8-fold increase in intestinal tumor load compared with ApcMin heterozygotes

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:45433 )
• mice have an 8-fold increase in intestinal tumor load compared with ApcMin heterozygotes




Genotype
MGI:4429627
cx9
Allelic
Composition		 B4galnt2a/B4galnt2b
Msh2tm1Htr/Msh2tm1Htr
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * SWR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B4galnt2a mutation (0 available); any B4galnt2 mutation (27 available)
B4galnt2b mutation (0 available); any B4galnt2 mutation (27 available)
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased enterocyte apoptosis ( J:54082 )
• enterocytes of mice treated with MNNG, temozolomide, and cisplatin exhibit reduced apoptosis compared to cells from similarly treated wild-type mice
• decreased induced apoptosis is not affected by O6-benzylguanine treatment

cellular
decreased enterocyte apoptosis ( J:54082 )
• enterocytes of mice treated with MNNG, temozolomide, and cisplatin exhibit reduced apoptosis compared to cells from similarly treated wild-type mice
• decreased induced apoptosis is not affected by O6-benzylguanine treatment




Genotype
MGI:5505262
cx10
Allelic
Composition		 Msh2tm1Htr/Msh2tm1Htr
Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu
Ungtm1Tld/Ungtm1Tld
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Cell Lines HEPD0529_1_C05
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
Smug1tm1a(EUCOMM)Hmgu mutation (0 available); any Smug1 mutation (13 available)
Ungtm1Tld mutation (0 available); any Ung mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:197809 )
• mean life expectancy is 107 days compared with 223 days for Msh2tm1Htr homozygotes
preweaning lethality, incomplete penetrance ( J:197809 )
• fewer than expected mice are identified at weaning

neoplasm
increased tumor incidence ( J:197809 )
• in all mice that die
increased lymphoma incidence ( J:197809 )
• in 4 of 5 mice with tumors




Genotype
MGI:5507886
cx11
Allelic
Composition		 Msh2tm1Htr/Msh2tm1Htr
Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu
Ungtm1Tld/Ungtm1Tld
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Cell Lines HEPD0529_1_B07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
Smug1tm1a(EUCOMM)Hmgu mutation (0 available); any Smug1 mutation (13 available)
Ungtm1Tld mutation (0 available); any Ung mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:197809 )
• mean life expectancy is 107 days compared with 223 days for Msh2tm1Htr homozygotes
preweaning lethality, incomplete penetrance ( J:197809 )
• fewer than expected mice are identified at weaning

neoplasm
increased tumor incidence ( J:197809 )
• in all mice that die
increased lymphoma incidence ( J:197809 )
• in 4 of 5 mice with tumors




Genotype
MGI:4429631
cx12
Allelic
Composition		 Hrhr/Hrhr
Msh2tm1Htr/Msh2tm1Htr
Xpatm1Tnka/Xpatm1Tnka
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrhr mutation (17 available); any Hr mutation (86 available)
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
Xpatm1Tnka mutation (0 available); any Xpa mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased mortality induced by ionizing radiation ( J:79734 )
• 32% of mice die 15 weeks after UVB-irradiation compared with 3% of similarly treated Xpatm1Tnka homozygotes
premature death ( J:79734 )
• 18% of mice die of lymphomas by 20 weeks of age

neoplasm
increased skin tumor incidence ( J:79734 )
• in 81% of mice by 52 weeks
increased skin papilloma incidence ( J:79734 )
• 9% of spontaneous skin tumors are papillomas
increased skin squamous cell carcinoma incidence ( J:79734 )
• 91% of skin tumors are squamous cell carcinomas
• all skin tumors in UVB-treated mice are diagnosed as squamous cell carcinomas
increased lymphoma incidence ( J:79734 )
• 18% of mice die of lymphomas by 20 weeks of age
increased incidence of tumors by UV-induction ( J:79734 )
• UVB-treated mice develop skin tumors a week earlier than similarly treated Xpatm1Tnka homozygotes
• all UVB-treated mice develop skin tumors, all of which are squamous cell carcinomas, at 10 weeks compared with 20 weeks for similarly treated Xpatm1Tnka homozygotes

integument
increased skin tumor incidence ( J:79734 )
• in 81% of mice by 52 weeks
increased skin papilloma incidence ( J:79734 )
• 9% of spontaneous skin tumors are papillomas
increased skin squamous cell carcinoma incidence ( J:79734 )
• 91% of skin tumors are squamous cell carcinomas
• all skin tumors in UVB-treated mice are diagnosed as squamous cell carcinomas

homeostasis/metabolism
increased mortality induced by ionizing radiation ( J:79734 )
• 32% of mice die 15 weeks after UVB-irradiation compared with 3% of similarly treated Xpatm1Tnka homozygotes




Genotype
MGI:4429609
cx13
Allelic
Composition		 Msh2tm1Htr/Msh2tm1Htr
Tap1tm1Hpl/Tap1tm1Hpl
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
Tap1tm1Hpl mutation (1 available); any Tap1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:45433 )
• mice that survive beyond 30 weeks exhibit a multitude of tumors types (erythroid, intestine, skin, uterus, mammary gland, lung, intestine, and hereditary nonpolyposis colorectal cancer)
increased gastrointestinal tumor incidence ( J:45433 )
• 80% of mice that survive beyond 30 weeks develop Hereditary Nonpolyposis Colon Cancer (HNPCC) tumors
increased mammary gland tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks
increased skin tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks
increased uterus tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks
increased lung tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks

integument
increased mammary gland tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks
increased skin tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks

reproductive system
increased uterus tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:45433 )
• 80% of mice that survive beyond 30 weeks develop Hereditary Nonpolyposis Colon Cancer (HNPCC) tumors

respiratory system
increased lung tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:45433 )
• in mice that survive beyond 30 weeks

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Lynch syndrome DOID:3883 OMIM:PS120435
 J:45433




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Send questions and comments to User Support. 		last database update
09/30/2025
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