About   Help   FAQ
Xpatm1Tnka
Targeted Allele Detail
Summary
Symbol: Xpatm1Tnka
Name: xeroderma pigmentosum, complementation group A; targeted mutation 1, Kiyoji Tanaka
MGI ID: MGI:2183931
Synonyms: XPA-
Gene: Xpa  Location: Chr4:46175222-46196345 bp, - strand  Genetic Position: Chr4, 24.49 cM, cytoband C2
Alliance: Xpatm1Tnka page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:28709
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  (C57BL/6 x CBA)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 4 was disrupted by the insertion of a neomycin selection cassette. Encoded protein was undetected in homozygous mutant mice by Western blot analysis of splenocyte extracts. (J:28709)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 9 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Xpatm1Tnka
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xpa Mutation:  22 strains or lines available
Notes
ES cell line = F1/1 ES (established from the F1 hybrid of male CBA and female C57BL/6).
References
Original:  J:28709 Nakane H, et al., High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene. Nature. 1995 Sep 14;377(6545):165-8
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory