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Gene Expression Data
Assay Details
Assay
Reference: J:264612 Morgani SM, et al., A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice. Dev Biol. 2018 Sep 1;441(1):104-126
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6286316
Gene symbol: Spry4
Gene name: sprouty RTK signaling antagonist 4
Reporter: YFP
Direct Detection
Results
Specimen 3A 16c: embryonic day 3.0; Spry4tm1Hadj/Spry4+ (more )
Note: 16 cells. Triple labeled: green - Spry4; red - Nanog (assay MGI:6286387); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS3: compacted morula Absent 3A 16c Venus , 3A 16c Merge + Nuclei
Specimen 3A 31c: embryonic day 3.5; Spry4tm1Hadj/Spry4+ (more )
Note: 31 cells. Triple labeled: green - Spry4; red - Nanog (assay MGI:6286387); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS4: compacted morula Absent 3A 31c Merge + Nuclei , 3A 31c Venus
Specimen 3A 59c: embryonic day 3.5; Spry4tm1Hadj/Spry4+ (more )
Note: 59 cells. Triple labeled: green - Spry4; red - Nanog (assay MGI:6286387); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS4: inner cell mass Absent 3A 59c Merge + Nuclei , 3A 59c Venus
Specimen 3A 89c: embryonic day 3.75; Spry4tm1Hadj/Spry4+ (more )
Note: 89 cells. Triple labeled: green - Spry4; red - Nanog (assay MGI:6286387); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS4: inner cell mass Present Non-Uniform 3A 89c Venus , 3A 89c Merge + Nuclei Expression increased as blastocysts developed. Expression in the inner cell mass (ICM) was heterogenous. Embryos were stained for Nanog and Gata6 to identify the epiblast (Nanog+), extraembryonic primitive endoderm (Gata6+), double positive, and double negative cell populations.
Specimen 3A 106c: embryonic day 4.0; Spry4tm1Hadj/Spry4+ (more )
Note: 106 cells. Triple labeled: green - Spry4; red - Nanog (assay MGI:6286387); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS5: inner cell mass Present Non-Uniform 3A 106c Merge + Nuclei , 3A 106c Venus Expression increased as blastocysts developed. Expression in the inner cell mass (ICM) was heterogenous. Embryos were stained for Nanog and Gata6 to identify the epiblast (Nanog+), extraembryonic primitive endoderm (Gata6+), double positive, and double negative cell populations.
Specimen 3A 148c: embryonic day 4.5; Spry4tm1Hadj/Spry4+ (more )
Note: 148 cells. Triple labeled: green - Spry4; red - Nanog (assay MGI:6286387); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS5: inner cell mass Present Non-Uniform 3A 148c Merge + Nuclei , 3A 148c Venus Expression increased as blastocysts developed. Expression in the inner cell mass (ICM) was heterogenous. Embryos were stained for Nanog and Gata6 to identify the epiblast (Nanog+), extraembryonic primitive endoderm (Gata6+), double positive, and double negative cell populations.
Specimen 3A 187c: embryonic day 5.0; Spry4tm1Hadj/Spry4+ (more )
Note: 187 cells. Triple labeled: green - Spry4; red - Nanog (assay MGI:6286387); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS5: inner cell mass Present Non-Uniform 3A 187c Venus , 3A 187c Merge + Nuclei Expression increased as blastocysts developed. Expression in the inner cell mass (ICM) was heterogenous. Embryos were stained for Nanog and Gata6 to identify the epiblast (Nanog+), extraembryonic primitive endoderm (Gata6+), double positive, and double negative cell populations.
Specimen not shown 16-32c: embryonic day 3.5; Spry4tm1Hadj/Spry4tm1Hadj (more )
Note: 16-32 cells
Structure Level Pattern Image Note
TS4: compacted morula Absent
Specimen not shown 32-64c: embryonic day 3.5; Spry4tm1Hadj/Spry4tm1Hadj (more )
Note: 32-64 cells
Structure Level Pattern Image Note
TS4: inner cell mass Absent
Specimen not shown 64-90c: embryonic day 3.75; Spry4tm1Hadj/Spry4tm1Hadj (more )
Note: 64-90 cells
Structure Level Pattern Image Note
TS4: inner cell mass Present Expression was higher in the homozygous embryos than in the heterozygous embryos.
TS4: trophectoderm Absent
Specimen not shown 90-120c: embryonic day 4.0; Spry4tm1Hadj/Spry4tm1Hadj (more )
Note: 90-120 cells
Structure Level Pattern Image Note
TS5: inner cell mass Present Expression was higher in the homozygous embryos than in the heterozygous embryos.
TS5: trophectoderm Absent
Specimen not shown 120-150c: embryonic day 4.5; Spry4tm1Hadj/Spry4tm1Hadj (more )
Note: 120-150 cells
Structure Level Pattern Image Note
TS5: inner cell mass Present Expression was higher in the homozygous embryos than in the heterozygous embryos.
TS5: trophectoderm Absent
Specimen not shown >150c: embryonic day 5.0; Spry4tm1Hadj/Spry4tm1Hadj (more )
Note: >150 cells
Structure Level Pattern Image Note
TS5: inner cell mass Present Expression was higher in the homozygous embryos than in the heterozygous embryos.
TS5: trophectoderm Absent
Specimen 6A MIP (3D): embryonic day 5.5; Spry4tm1Hadj/Spry4+ (more )
Note: Triple labeled: green - Spry4; red - Sox2 (assay MGI:6286394); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS7: primitive endoderm Present 6A MIP (3D) Merge , 6A MIP (3D) Venus
TS7: epiblast Weak 6A MIP (3D) Merge , 6A MIP (3D) Venus
TS7: extraembryonic ectoderm Weak 6A MIP (3D) Merge , 6A MIP (3D) Venus
Specimen 6A Sagittal: embryonic day 5.5; Spry4tm1Hadj/Spry4+ (more )
Note: Triple labeled: green - Spry4; red - Sox2 (assay MGI:6286394); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS7: primitive endoderm Present 6A Sagittal Merge , 6A Sagittal Venus
TS7: epiblast Weak 6A Sagittal Merge , 6A Sagittal Venus
TS7: extraembryonic ectoderm Weak 6A Sagittal Merge , 6A Sagittal Venus
Specimen 6A Trans: embryonic day 5.5; Spry4tm1Hadj/Spry4+ (more )
Note: Triple labeled: green - Spry4; red - Sox2 (assay MGI:6286394); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS7: primitive endoderm Present 6A Trans Merge , 6A Trans Venus
TS7: epiblast Weak 6A Trans Merge , 6A Trans Venus
Specimen 6B MIP (3D): embryonic day 6.5-6.75; Spry4tm1Hadj/Spry4+ (more )
Note: Triple labeled: green - Spry4; red - Brachyury (assay MGI:6286395); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS9: endoderm Present 6B MIP (3D) Venus , 6B MIP (3D) Merge
TS9: extraembryonic ectoderm Weak 6B MIP (3D) Merge , 6B MIP (3D) Venus
TS9: mesoderm Weak 6B MIP (3D) Merge , 6B MIP (3D) Venus
TS9: primitive streak Weak 6B MIP (3D) Merge , 6B MIP (3D) Venus
Specimen 6B Sagittal: embryonic day 6.5-6.75; Spry4tm1Hadj/Spry4+ (more )
Note: Triple labeled: green - Spry4; red - Brachyury (assay MGI:6286395); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS9: endoderm Present 6B Sagittal Merge , 6B Sagittal Venus
TS9: extraembryonic ectoderm Weak 6B Sagittal Venus , 6B Sagittal Merge
TS9: mesoderm Weak 6B Sagittal Venus , 6B Sagittal Merge
TS9: primitive streak Weak 6B Sagittal Venus , 6B Sagittal Merge
Specimen 6B Trans: embryonic day 6.5-6.75; Spry4tm1Hadj/Spry4+ (more )
Note: Triple labeled: green - Spry4; red - Brachyury (assay MGI:6286395); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS9: endoderm Present 6B Trans Venus , 6B Trans Merge
TS9: extraembryonic ectoderm Weak 6B Trans Merge , 6B Trans Venus
TS9: mesoderm Weak 6B Trans Merge , 6B Trans Venus
TS9: primitive streak Weak 6B Trans Merge , 6B Trans Venus
Specimen 6C: embryonic day 6.5-6.75; Spry4tm1Hadj/Spry4+ (more )
Note: Double labeled: green - Spry4; red - Brachyury (assay MGI:6286395).
Structure Level Pattern Image Note
TS9: endoderm Present 6C Venus , 6C Merge
TS9: extraembryonic ectoderm Weak 6C Venus , 6C Merge
TS9: primitive streak Weak 6C Venus , 6C Merge
Specimen 6D: embryonic day 6.5-6.75; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS9: endoderm Present 6D Expression was significantly higher within endoderm cells compared to the epiblast and primitive streak/mesoderm.
TS9: mesoderm Weak 6D
TS9: primitive streak Weak 6D
Specimen 7A MIP (3D): embryonic day 7.75-8.0; Spry4tm1Hadj/Spry4+ (more )
Note: Triple labeled: green - Spry4; red - Brachyury (assay MGI:6286395); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS11: germ layer Present Regionally restricted 7A MIP (3D) Merge , 7A MIP (3D) Venus Expression was detected in epiblast.
TS11: primitive endoderm Present 7A MIP (3D) Venus , 7A MIP (3D) Merge Expression was highest in endoderm.
TS11: primitive streak Present 7A MIP (3D) Venus , 7A MIP (3D) Merge Expression was detected in cells exiting the primitive streak.
Specimen 7A Sagittal: embryonic day 7.75-8.0; Spry4tm1Hadj/Spry4+ (more )
Note: Triple labeled: green - Spry4; red - Brachyury (assay MGI:6286395); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS11: germ layer Present Regionally restricted 7A Anterior (1) Venus , 7A Anterior (1) Merge , 7A Sagittal Merge , 7A Sagittal Venus Expression was detected in epiblast.
TS11: primitive endoderm Present 7A Anterior (1) Venus , 7A Sagittal Venus , 7A Anterior (1) Merge , 7A Sagittal Merge Expression was highest in endoderm.
TS11: primitive streak Present Regionally restricted 7A Sagittal Venus , 7A Posterior (2) Venus , 7A Posterior (2) Merge , 7A Sagittal Merge Expression was detected in cells exiting the primitive streak.
Specimen 7B: embryonic day 7.75-8.0; Spry4tm1Hadj/Spry4+ (more )
Note: Triple labeled: green - Spry4; red - Brachyury (assay MGI:6286395); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS11: germ layer Present Regionally restricted 7B Venus , 7B Merge Expression was detected in epiblast.
TS11: primitive endoderm Present 7B Venus , 7B Merge Expression was highest in endoderm.
TS11: primitive streak Present Regionally restricted 7B Venus , 7B Merge Expression was detected in cells exiting the primitive streak.
Specimen 9A: embryonic day 8.5; Spry4tm1Hadj/Spry4+ (more )
Note: 11 somites
Structure Level Pattern Image Note
TS13: unsegmented mesenchyme Present 9A Venus , 9A Merge
TS13: somite Present Regionally restricted 9A Merge , 9A Venus Expression was detected in newly formed somites.
TS13: 1st branchial arch Weak 9A Merge , 9A Venus
Specimen 9B: embryonic day 8.75; Spry4tm1Hadj/Spry4+ (more )
Note: 16 somites
Structure Level Pattern Image Note
TS14: unsegmented mesenchyme Present 9B Venus , 9B Merge
TS14: somite Present Regionally restricted 9B Merge , 9B Venus Expression was detected in newly formed somites.
TS14: 1st branchial arch Weak 9B Venus , 9B Merge
TS14: 2nd branchial arch Weak 9B Venus , 9B Merge
Specimen 9D: embryonic day 10.5; Spry4tm1Hadj/Spry4+ (more )
Note: 41 somites
Structure Level Pattern Image Note
TS18: fronto-nasal process Present 9D Venus top , 9D Merge top
TS18: midbrain-hindbrain junction Present 9D Venus top , 9D Merge top
TS18: tail unsegmented mesenchyme Present 9D Venus top , 9D Merge top
TS18: somite Present Regionally restricted 9D Venus top , 9D Merge top Expression was detected in newly formed somites.
TS18: 1st branchial arch mandibular component Weak 9D Venus top , 9D Merge top
TS18: 1st branchial arch maxillary component Weak 9D Venus top , 9D Merge top
Specimen 9D fl: embryonic day 10.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS18: forelimb bud Present 9D Merge fl , 9D Venus fl
Specimen 9D hl: embryonic day 10.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS18: hindlimb bud Present 9D Venus hl , 9D Merge hl
Specimen 9E: embryonic day 10.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS18: surface ectoderm Strong Regionally restricted 9E left , 9E right High levels were observed within the surface ectoderm of the forelimb bud.
TS18: forelimb bud mesenchyme Strong Graded 9E right , 9E left There was a proximal-distal gradient observed in the expression pattern in limb bud mesenchyme.
TS18: forelimb bud apical ectodermal ridge Weak 9E left , 9E right
Specimen 9F: embryonic day 10.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS18: surface ectoderm Strong Regionally restricted 9F High levels were observed within the surface ectoderm of the forelimb bud.
TS18: forelimb bud mesenchyme Strong Graded 9F There was a proximal-distal gradient observed in the expression pattern in limb bud mesenchyme.
TS18: forelimb bud apical ectodermal ridge Weak 9F
Specimen 9H lateral: embryonic day 12.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS20: face Present 9H Merge lateral view , 9H Venus lateral view
TS20: forelimb Present 9H Merge lateral view , 9H Venus lateral view
TS20: hindlimb Present 9H Merge lateral view , 9H Venus lateral view
TS20: midbrain-hindbrain junction Present 9H Merge lateral view , 9H Venus lateral view
TS20: somite Present 9H Merge lateral view , 9H Venus lateral view
TS20: tail Present 9H Merge lateral view , 9H Venus lateral view
Specimen 9H dorsal: embryonic day 12.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS20: somite Present 9H Merge dorsal view , 9H Venus dorsal view
Specimen 9H fl: embryonic day 12.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS20: forelimb Present 9H Venus fl , 9H Merge fl Expression was seen at the distal edge. Signal seen in the digits was non-specific.
Specimen 9H hl: embryonic day 12.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS20: hindlimb Present Regionally restricted 9H Merge hl , 9H Venus hl Expression was seen at the distal edge. Signal seen in the digits was non-specific.
Specimen 9H tail: embryonic day 12.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS20: tail Present 9H Venus tail , 9H Merge tail
Specimen 10 female reproductive system: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: ovary Present 10_Female reproductive system
TS28: oviduct Present 10_Female reproductive system
TS28: uterus Present 10_Female reproductive system
Specimen 10 oviduct: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: oviduct Present 10_Oviduct
Specimen 10 ovary: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: ovary theca Present 10_Ovary
Specimen 10 uterus: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: endometrium stroma Present Regionally restricted 10_Uterus Expression was detected in the mesenchyme underlying the uterine epithelium.
Specimen 10 kidney: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: metanephros Present 10_Kidney whole mount
Specimen 10 kidney section top: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: metanephros Present 10_Kidney section top
Specimen 10 kidney section bottom: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: glomerular tuft Present 10_Kidney section bottom
Specimen 10 spleen: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: spleen Present 10_Spleen whole mount
Specimen 10 spleen section: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: spleen Present 10_Spleen section
Specimen 10 stomach: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: stomach Present 10_Stomach whole mount
Specimen 10 stomach section: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: stomach Present 10_Stomach section
Specimen 10 liver: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: liver Present 10_Liver whole mount
Specimen 10 liver section: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: liver Present 10_Liver section
Specimen 10 heart: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: heart Present 10_Heart whole mount
Specimen 10 heart section: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: heart Present 10_Heart section
Specimen 10 lung: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: lung Present 10_Lung whole mount
Specimen 10 lung section: postnatal month 3; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: lung Present 10_Lung section
Specimen S6A MIP (3D): embryonic day 6.75-7.0; Spry4tm1Hadj/Spry4+ (more )
Note: Double labeled: green - Spry4; red - Sox17 (assay MGI:6286492).
Structure Level Pattern Image Note
TS9: germ layer Present Regionally restricted S6A MIP (3D) Venus , S6A MIP (3D) Merge Expression was detected in epiblast.
TS9: endoderm Present S6A MIP (3D) Merge , S6A MIP (3D) Venus
TS9: mesoderm Present S6A MIP (3D) Merge , S6A MIP (3D) Venus
TS9: primitive streak Present S6A MIP (3D) Merge , S6A MIP (3D) Venus
Specimen S6A Sagittal: embryonic day 6.75-7.0; Spry4tm1Hadj/Spry4+ (more )
Note: Double labeled: green - Spry4; red - Sox17 (assay MGI:6286492).
Structure Level Pattern Image Note
TS9: germ layer Present Regionally restricted S6A Sagittal Venus , S6A Sagittal Merge Expression was detected in epiblast.
TS9: endoderm Present S6A Sagittal Venus , S6A Sagittal Merge
TS9: mesoderm Present S6A Sagittal Venus , S6A Sagittal Merge
TS9: primitive streak Present S6A Sagittal Venus , S6A Sagittal Merge
Specimen S6A Transverse: embryonic day 6.75-7.0; Spry4tm1Hadj/Spry4+ (more )
Note: Double labeled: green - Spry4; red - Sox17 (assay MGI:6286492).
Structure Level Pattern Image Note
TS9: germ layer Present Regionally restricted S6A Transverse Merge , S6A Transverse Venus Expression was detected in epiblast.
TS9: endoderm Present S6A Transverse Venus , S6A Transverse Merge
Specimen S6B MIP (3D): embryonic day 6.75-7.0; Spry4tm1Hadj/Spry4+ (more )
Note: Triple labeled: green - Spry4; red - Foxa2 (assay MGI:6286498); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS9: germ layer Present Regionally restricted S6B MIP (3D) Venus , S6B MIP (3D) Merge Expression was detected in epiblast.
TS9: endoderm Present S6B MIP (3D) Merge , S6B MIP (3D) Venus
TS9: mesoderm Present S6B MIP (3D) Merge , S6B MIP (3D) Venus
TS9: primitive streak Present S6B MIP (3D) Merge , S6B MIP (3D) Venus
Specimen S6B Sagittal: embryonic day 6.75-7.0; Spry4tm1Hadj/Spry4+ (more )
Note: Triple labeled: green - Spry4; red - Foxa2 (assay MGI:6286498); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS9: germ layer Present Regionally restricted S6B Sagittal Merge , S6B Sagittal Venus Expression was detected in epiblast.
TS9: endoderm Present S6B Sagittal Merge , S6B Sagittal Venus
TS9: mesoderm Present S6B Sagittal Merge , S6B Sagittal Venus
TS9: primitive streak Present S6B Sagittal Merge , S6B Sagittal Venus
Specimen S6B Transverse: embryonic day 6.75-7.0; Spry4tm1Hadj/Spry4+ (more )
Note: Triple labeled: green - Spry4; red - Foxa2 (assay MGI:6286498); blue - Gata6 (assay MGI:6286386).
Structure Level Pattern Image Note
TS9: germ layer Present Regionally restricted S6B Transverse Venus , S6B Transverse Merge Expression was detected in epiblast.
TS9: endoderm Present S6B Transverse Venus , S6B Transverse Merge
TS9: primitive streak Present S6B Transverse Venus , S6B Transverse Merge
Specimen S8C: embryonic day 12.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS20: hand Present Regionally restricted S8C Merge , S8C Venus Expression was detected at the distal edge of the forepaw.
Specimen S8D Sagittal: embryonic day 12.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS20: hand Present Regionally restricted S8D Sagittal Venus , S8D Sagittal Merge Expression was detected at the distal edge of the forepaw. Fluorescence observed within the proximal digit and interdigit regions was non-specific.
Specimen S8D Transverse: embryonic day 12.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS20: hand Present Regionally restricted S8D Transvers Merge , S8D Transverse Venus Expression was detected at the distal edge of the forepaw. Fluorescence observed within the proximal digit and interdigit regions was non-specific.
Specimen S9 E10.5 forebrain: embryonic day 10.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS17: head mesenchyme Present Regionally restricted S9_Forebrain Expression was detected in the cephalic mesenchyme.
Specimen S9 E10.5 Rathke's pouch: embryonic day 10.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS17: Rathke's pouch Present S9_Rathke's pouch
Specimen S9 E10.5 lungs: embryonic day 10.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS17: lung mesenchyme Present Regionally restricted S9_Lungs Expression was detected in the distal mesenchyme of the lungs.
Specimen S9 E10.5 heart: embryonic day 10.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS17: heart Present S9_Heart
Specimen S9 E10.5 liver: embryonic day 10.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS17: liver Present S9_Liver
Specimen S9 E10.5 tail: embryonic day 10.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS17: tail Present S9_Tail (sagittal)
Specimen S9 E13.5 surface ectoderm: embryonic day 13.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS21: non-neural ectoderm Ambiguous S9_Surface ectoderm
Specimen S9 E13.5 thoracic vein: embryonic day 13.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS21: vein Ambiguous S9_Thoracic vein The sample was thoracic vein.
Specimen S9 E13.5 duodenum top: embryonic day 13.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS21: duodenum Present S9_Duodenum top
Specimen S9 E13.5 duodenum bottom: embryonic day 13.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS21: duodenum Present S9_Duodenum bottom
Specimen S9 E13.5 kidney: embryonic day 13.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS21: metanephros Present S9_Kidney
Specimen S9 E13.5 genital tubercle: embryonic day 13.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS21: genital tubercle mesenchyme Present S9_Genital tubercle
Specimen S9 E13.5 tail transverse: embryonic day 13.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS21: tail Present S9_Tail top
Specimen S9 E13.5 tail sagittal: embryonic day 13.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS21: tail Present S9_Tail bottom
Specimen S9 E13.5 hindlimb: embryonic day 13.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS21: hindlimb Present S9_Hindlimb
Specimen S9 E13.5 midbrain: embryonic day 13.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS21: midbrain Present S9_Midbrain
Specimen S9 E13.5 nasal cavity: embryonic day 13.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS21: nasal mesenchyme Present S9_Nasal cavity
Specimen S9 E13.5 optic cup: embryonic day 13.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS21: eye mesenchyme Present Regionally restricted S9_Optic cup Expression was detected in mesenchymal cells between the primary lens fiber and neuroretinal layers of the optic cup.
Specimen S9 E13.5 somites: embryonic day 13.5; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS21: dorsal root ganglion Present S9_Somites
TS21: somite Present S9_Somites
Specimen S10 cerebellum: postnatal month 2; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present S10_Cerebellum Expression was detected in cells within the Purkinje cell layer, likely marking Bergmann glia.
Specimen S10 choroid plexus top: postnatal month 2; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: choroid plexus Present Regionally restricted S10_Choroid plexus top Expression was detected in cells underlying the epithelium of the choroid plexus.
Specimen S10 choroid plexus bottom: postnatal month 2; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: choroid plexus Present Regionally restricted S10_Choroid plexus bottom Expression was detected in cells underlying the epithelium of the choroid plexus.
Specimen S10 olfactory bulb glomerular layer: postnatal month 2; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: main olfactory bulb glomerular layer Present S10_Olfactory bulb top
Specimen S10 olfactory bulb periglomerular layer: postnatal month 2; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: main olfactory bulb layer Present Regionally restricted S10_Olfactory bulb bottom Expression was detected in the periglomerular layer of the olfactory bulb.
Specimen S10 cerebral cortex: postnatal month 2; Spry4tm1Hadj/Spry4+ (more )
Structure Level Pattern Image Note
TS28: cerebral cortex Present Widespread S10_Cerebral cortex
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory