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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Ret
ret proto-oncogene
MGI:97902
56 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Baxtm1Sjk/Baxtm1Sjk
Rettm1Heno/Rettm3.1(Bcl2l1)Heno
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129X1/SvJ * C57BL/6 * CBA
abnormal enteric neuron morphology J:159854
Epha4Gt(PST038)Byg/Epha4Gt(PST038)Byg
Rettm1.1Kln/Rettm1.1Kln
involves: 129/Sv * BALB/c * C57BL/6 * CBA/J
abnormal axon guidance J:110955
abnormal innervation pattern to muscle J:110955
Gfra1tm3Jmi/Gfra1tm3Jmi
Rettm14(Gfra1)Jmi/Ret+
involves: 129X1/SvJ
no abnormal phenotype detected J:130616
Islr2tm1.1Ddg/Islr2tm1.1Ddg
Rettm1.1Ddg/Ret+
involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
abnormal neuron morphology J:154926
Islr2tm1.1Ddg/Islr2tm1.1Ddg
Rettm1.1Ddg/Rettm1.1Ddg
involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
abnormal neuron morphology J:154926
Kif1bpem1Hmy/Kif1bpem1Hmy
Rettm1Jmi/Ret+
involves: 129X1/SvJ
abnormal embryo development J:253679
Kif1bpem1Hmy/Kif1bpem1Hmy
Rettm1Jmi/Rettm1Jmi
involves: 129X1/SvJ
abnormal embryo development J:253679
Lhx1tm1Tmj/Lhx1+
Rettm1Kln/Rettm1Kln
Tg(Nes-cre)1Kln/0
involves: 129/Sv * BALB/c * C57BL/6 * CBA/J * SJL
abnormal axon guidance J:110955
Lhx1tm1Tmj/Lhx1+
Rettm1.1Kln/Rettm1.1Kln
involves: 129/Sv * BALB/c * C57BL/6 * CBA/J
abnormal axon guidance J:110955
Mrgprdtm1Mjz/?
Rettm1Ddg/Rettm1Ddg
H2afvTg(Wnt1-cre)11Rth/0
involves: 129 * 129S1/Sv * C57BL/6 * C57BL/6J * CBA/J
abnormal neurite morphology J:126484
Pax2tm1Pgr/Pax2+
Rettm1Cos/Ret+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
absent kidney J:117753
absent ureter J:117753
decreased renal glomerulus number J:117753
impaired branching involved in ureteric bud morphogenesis J:117753
preweaning lethality, incomplete penetrance J:117753
renal hypoplasia J:117753
single kidney J:117753
Rettm1(RET)Vpa/Rettm1(RET)Vpa
involves: 129P2/OlaHsd
no abnormal phenotype detected J:71588, J:102170
Rettm1(RET)Vpa/Rettm2(RET)Vpa
involves: 129P2/OlaHsd
no abnormal phenotype detected J:71588
Rettm1Cos/Ret+
Wnt11tm1Amc/Wnt11+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1
small kidney J:83430
Rettm1Cos/Ret+
Wnt11tm1Amc/Wnt11tm1Amc
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1
impaired branching involved in ureteric bud morphogenesis J:83430
small kidney J:83430
Rettm1Cos/Rettm2(RET)Jmi
involves: 129S/Sv * C57BL/6
aganglionic megacolon J:135153
Rettm1Cos/Rettm2(RET)Vpa
involves: 129P2/OlaHsd * 129S/SvEv
abnormal kidney morphology J:71588
renal hypoplasia J:71588
Rettm1Heno/Rettm2(RET)Jmi
involves: 129X1/SvJ * C57BL/6
abnormal defecation J:159854
abnormal enteric neural crest cell migration J:159854
abnormal feces composition J:159854
absent enteric neurons J:159854
decreased body weight J:159854
normal nervous system phenotype J:159854
postnatal growth retardation J:159854
postnatal lethality, incomplete penetrance J:159854
premature death J:159854
normal renal/urinary system phenotype J:159854
Rettm2(RET)Heno/Rettm2(RET)Jmi
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S/Sv * C57BL/6 * CBA
abnormal large intestine morphology J:135153
decreased neural crest cell number J:135153
Rettm2(RET)Jmi/Rettm2(RET)Jmi
involves: 129X1/SvJ * C57BL/6
dilated ureter J:105047
hydronephrosis J:105047
Rettm2(RET)Jmi/Rettm2(RET)Jmi
Not Specified
normal nervous system phenotype J:93262
Rettm2(RET)Jmi/Rettm3.1(Bcl2l1)Heno
involves: 129/Sv * C57BL/6
abnormal enteric neural crest cell migration J:159854
absent enteric neurons J:159854
normal digestive/alimentary phenotype J:159854
normal mortality/aging J:159854
Rettm2(RET)Vpa/Rettm2(RET)Vpa
involves: 129P2/OlaHsd
abnormal enteric ganglia morphology J:71588
abnormal enteric neural crest cell migration J:71588
abnormal kidney morphology J:71588
absent enteric neural crest cell J:71588
impaired branching involved in ureteric bud morphogenesis J:71588
kidney cysts J:71588
postnatal growth retardation J:71588
preweaning lethality, incomplete penetrance J:71588
renal hypoplasia J:71588
Rettm2(RET)Vpa/Rettm2(RET)Vpa
involves: 129P2/OlaHsd * C57BL/6J
abnormal enteric ganglia morphology J:102170
small kidney J:102170
Rettm2.1Cos/?
Tg(Th-MYCN)41Waw/0
involves: 129S1/Sv * BALB/c * C57BL/6J
increased neuroblastoma incidence J:261033
premature death J:261033
Rettm2.1Heno/Rettm2(RET)Jmi
involves: 129S/Sv * C57BL/6 * FVB/N
abnormal enteric ganglia morphology J:135153
abnormal enteric neural crest cell migration J:135153
Tg(SFTPC-KIF5B/RET)1Tkoh/0
involves: C57BL/6J
increased lung adenocarcinoma incidence J:215989
increased lung adenoma incidence J:215989
increased lung tumor incidence J:215989
Tg(TG-RET/CCDC6)1Cled/0
involves: FVB/N
increased thyroid carcinoma incidence J:55883, J:93679
Tg(TG-RET/CCDC6)42Cled/0
involves: FVB/N
abnormal thyroid follicle morphology J:55883
abnormal thyroid gland physiology J:55883
decreased activity of thyroid gland J:55883, J:93679
decreased body size J:93679
decreased circulating thyroxine level J:93679
decreased circulating triiodothyronine level J:93679
increased circulating thyroid-stimulating hormone level J:93679
increased thyroid carcinoma incidence J:55883, J:93679
increased thyroid-stimulating hormone level J:55883
increased thyrotroph cell number J:93679
increased thyrotroph cell size J:93679
paraphimosis J:93679
Tg(TG-RET/NCOA4)3209Rstn/0
involves: C57BL/6
abnormal thyroid follicular cell morphology J:51366
abnormal thyroid gland morphology J:51366
enlarged thyroid gland J:51366
increased metastatic potential J:51366
increased thyroid carcinoma incidence J:51366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory