41 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Baxtm1Sjk/Baxtm1Sjk Rettm1Heno/Rettm3.1(Bcl2l1)Heno Tg(CAG-cre/Esr1*)5Amc/0 involves: 129X1/SvJ * C57BL/6 * CBA	abnormal enteric neuron morphology	J:159854
Epha4Gt(PST038)Byg/Epha4Gt(PST038)Byg Rettm1.1Kln/Rettm1.1Kln involves: 129/Sv * BALB/c * C57BL/6 * CBA/J	abnormal axon guidance	J:110955
	abnormal innervation pattern to muscle	J:110955
Gfra1tm3Jmi/Gfra1tm3Jmi Rettm14(Gfra1)Jmi/Ret+ involves: 129X1/SvJ	no abnormal phenotype detected	J:130616
Islr2tm1.1Ddg/Islr2tm1.1Ddg Rettm1.1Ddg/Ret+ involves: 129S6/SvEvTac * BALB/cJ * C57BL/6	abnormal neuron morphology	J:154926
Islr2tm1.1Ddg/Islr2tm1.1Ddg Rettm1.1Ddg/Rettm1.1Ddg involves: 129S6/SvEvTac * BALB/cJ * C57BL/6	abnormal neuron morphology	J:154926
Kifbpem1Hmy/Kifbpem1Hmy Rettm1Jmi/Ret+ involves: 129X1/SvJ	abnormal embryo development	J:253679
Kifbpem1Hmy/Kifbpem1Hmy Rettm1Jmi/Rettm1Jmi involves: 129X1/SvJ	abnormal embryo development	J:253679
Lhx1tm1Tmj/Lhx1+ Rettm1Kln/Rettm1Kln Tg(Nes-cre)1Kln/0 involves: 129/Sv * BALB/c * C57BL/6 * CBA/J * SJL	abnormal axon guidance	J:110955
Lhx1tm1Tmj/Lhx1+ Rettm1.1Kln/Rettm1.1Kln involves: 129/Sv * BALB/c * C57BL/6 * CBA/J	abnormal axon guidance	J:110955
Mrgprdtm1Mjz/? Rettm1Ddg/Rettm1Ddg H2az2Tg(Wnt1-cre)11Rth/H2az2+ involves: 129 * 129S1/Sv * C57BL/6 * C57BL/6J * CBA/J	abnormal neurite morphology	J:126484
Pax2tm1Pgr/Pax2+ Rettm1Cos/Ret+ involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ	absent kidney	J:117753
	absent ureter	J:117753
	decreased renal glomerulus number	J:117753
	impaired branching involved in ureteric bud morphogenesis	J:117753
	preweaning lethality, incomplete penetrance	J:117753
	renal hypoplasia	J:117753
	single kidney	J:117753
Rettm1(RET)Vpa/Rettm1(RET)Vpa involves: 129P2/OlaHsd	no abnormal phenotype detected	J:71588, J:102170
Rettm1(RET)Vpa/Rettm2(RET)Vpa involves: 129P2/OlaHsd	no abnormal phenotype detected	J:71588
Rettm1Cos/Ret+ Wnt11tm1Amc/Wnt11+ involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1	small kidney	J:83430
Rettm1Cos/Ret+ Wnt11tm1Amc/Wnt11tm1Amc involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1	impaired branching involved in ureteric bud morphogenesis	J:83430
	small kidney	J:83430
Rettm1Cos/Rettm2(RET)Jmi involves: 129S/Sv * C57BL/6	aganglionic megacolon	J:135153
Rettm1Cos/Rettm2(RET)Vpa involves: 129P2/OlaHsd * 129S/SvEv	abnormal kidney morphology	J:71588
	renal hypoplasia	J:71588
Rettm1Heno/Rettm2(RET)Jmi involves: 129X1/SvJ * C57BL/6	abnormal defecation	J:159854
	abnormal enteric neural crest cell migration	J:159854
	abnormal feces composition	J:159854
	absent enteric neurons	J:159854
	decreased body weight	J:159854
	normal nervous system phenotype	J:159854
	postnatal growth retardation	J:159854
	postnatal lethality, incomplete penetrance	J:159854
	premature death	J:159854
	normal renal/urinary system phenotype	J:159854
Rettm1Heno/Rettm3.1(Bcl2l1)Heno Tg(CAG-cre/Esr1*)5Amc/0 involves: 129X1/SvJ * C57BL/6 * CBA	abnormal defecation	J:159854
	abnormal enteric neuron morphology	J:159854
	abnormal feces composition	J:159854
	decreased body weight	J:159854
Rettm2(RET)Heno/Rettm2(RET)Jmi Tg(CAG-cre/Esr1*)5Amc/0 involves: 129S/Sv * C57BL/6 * CBA	abnormal large intestine morphology	J:135153
	decreased neural crest cell number	J:135153
Rettm2(RET)Heno/Rettm3.1(Bcl2l1)Heno involves: 129/Sv * C57BL/6	absent enteric neurons	J:159854
	absent kidney	J:159854
Rettm2(RET)Jmi/Rettm2(RET)Jmi involves: 129X1/SvJ * C57BL/6	dilated ureter	J:105047
	hydronephrosis	J:105047
Rettm2(RET)Jmi/Rettm2(RET)Jmi Not Specified	normal nervous system phenotype	J:93262
Rettm2(RET)Jmi/Rettm3.1(Bcl2l1)Heno involves: 129/Sv * C57BL/6	abnormal enteric neural crest cell migration	J:159854
	absent enteric neurons	J:159854
	normal digestive/alimentary phenotype	J:159854
	normal mortality/aging	J:159854
Rettm2(RET)Vpa/Rettm2(RET)Vpa involves: 129P2/OlaHsd	abnormal enteric ganglia morphology	J:71588
	abnormal enteric neural crest cell migration	J:71588
	abnormal kidney morphology	J:71588
	absent enteric neural crest cell	J:71588
	impaired branching involved in ureteric bud morphogenesis	J:71588
	kidney cyst	J:71588
	postnatal growth retardation	J:71588
	preweaning lethality, incomplete penetrance	J:71588
	renal hypoplasia	J:71588
Rettm2(RET)Vpa/Rettm2(RET)Vpa involves: 129P2/OlaHsd * C57BL/6J	abnormal enteric ganglia morphology	J:102170
	small kidney	J:102170
Rettm2.1Cos/? Tg(Th-MYCN)41Waw/0 involves: 129S1/Sv * BALB/c * C57BL/6J	increased neuroblastoma incidence	J:261033
	premature death	J:261033
Rettm2.1Heno/Rettm2(RET)Jmi involves: 129S/Sv * C57BL/6 * FVB/N	abnormal enteric ganglia morphology	J:135153
	abnormal enteric neural crest cell migration	J:135153
Rettm3(RET)Vpa/Rettm3(RET)Vpa involves: 129P2/OlaHsd * C57BL/6J	abnormal enteric ganglia morphology	J:102170
	abnormal intestinal peristalsis	J:102170
	abnormal kidney morphology	J:102170
	absent enteric neural crest cell	J:102170
	impaired branching involved in ureteric bud morphogenesis	J:102170
	neonatal lethality	J:102170
	renal hypoplasia	J:102170
Rettm3.1(Bcl2l1)Heno/Ret+ involves: 129/Sv * C57BL/6	decreased neuron apoptosis	J:159854
	normal digestive/alimentary phenotype	J:159854
	normal nervous system phenotype	J:159854
Rettm4(RET)Vpa/Rettm4(RET)Vpa either: 129S1/Sv-Rettm4(RET)Vpa or (involves: 129S1/Sv * C57BL/6J)	no abnormal phenotype detected	J:102170
Rettm5(RET)Jmi/Rettm5(RET)Jmi involves: 129X1/SvJ * 129S1/Sv * C57BL/6	no abnormal phenotype detected	J:105047
Rettm5(RET)Vpa/Rettm5(RET)Vpa either: 129S1/Sv-Rettm5(RET)Vpa or (involves: 129S1/Sv * C57BL/6J)	abnormal enteric ganglia morphology	J:102170
	decreased renal glomerulus number	J:102170
	kidney cyst	J:102170
	small kidney	J:102170
Rettm6(RET)Jmi/Rettm6(RET)Jmi involves: 129X1/SvJ * 129S1/Sv * C57BL/6	no abnormal phenotype detected	J:105047
Rettm13.1Jmi/Rettm13Jmi Slc6a3tm1(cre)Xz/Slc6a3+ involves: 129S1/Sv * 129X1/SvJ	decreased locomotor activity	J:114682
	normal nervous system phenotype	J:114682