Lhx1^tm1Tmj
Targeted Allele Detail

Summary

• Symbol: Lhx1^tm1Tmj
• Name: LIM homeobox protein 1; targeted mutation 1, Thomas M Jessell
• MGI ID: MGI:2385717
• Synonyms: Lhx1^LacZ, Lim1^lacZ, Lim1-lacZ, Lim1^tlz, Lim^tlz
• Gene: Lhx1 Location: Chr11:84409110-84416361 bp, - strand Genetic Position: Chr11, 51.31 cM
• Alliance: Lhx1^tm1Tmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42219
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the endogenous gene was replaced with an IRES-tau-lacZ-floxed neo cassette via homologous recombination. The neo cassette was excised from targeted ES cells by the transient transfection of cre expressing plasmids. The expression pattern of beta-galactosidase was similar to that of the endogenous gene. (J:42219, J:63423)

Expression

In Mice Carrying this Mutation:	178 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx1 Mutation: 22 strains or lines available

Notes

J:42219 and J:63423 give W95 as the ES cell line. The strain of origin is given in J:63423 supplemental data as 129/Sv.

References

• Original: J:42219 Shawlot W, et al., Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse. Development. 1999 Nov;126(22):4925-32
• All: 15 reference(s)