Ret^{tm14(Gfra1)Jmi}
Targeted Allele Detail

Summary

• Symbol: Ret^{tm14(Gfra1)Jmi}
• Name: ret proto-oncogene; targeted mutation 14, Jeffrey Milbrandt
• MGI ID: MGI:3774316
• Synonyms: Ret^GFRalpha1
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^{tm14(Gfra1)Jmi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130616
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame of Gfra1 and a floxed neo cassette were knocked into the coding exon. The neo cassette was removed by subsequent cre-mediated recombination. Expression of the knocked in transcript was confirmed by histochemistry. (J:130616)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 53 strains or lines available

References

• Original: J:130616 Enomoto H, et al., GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration. Neuron. 2004 Nov 18;44(4):623-36
• All: 2 reference(s)