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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Lgals3
lectin, galactose binding, soluble 3
MGI:96778
80 phenotypes from 3 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Lgals3em1Vari/Lgals3em1Vari
involves: C3H/HeJ * C57BL/6J
decreased bone strength J:329549
decreased bone trabecular spacing J:329549
normal growth/size/body region phenotype J:329549
increased bone mineral density of vertebrae J:329549
increased bone trabecula number J:329549
increased bone volume J:329549
increased compact bone volume J:329549
increased internal diameter of femur J:329549
increased trabecular bone connectivity density J:329549
increased trabecular bone mass J:329549
increased trabecular bone thickness J:329549
increased trabecular bone volume J:329549
increased volumetric bone mineral density J:329549
normal skeleton phenotype J:329549
Lgals3tm1Ftl/Lgals3tm1Ftl
B6.129S2-Lgals3tm1Ftl
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology J:109126
abnormal dendritic cell physiology J:109126
abnormal interferon secretion J:109126
abnormal response to infection J:109126
brain inflammation J:109126
decreased macrophage cell number J:109126
increased IgG level J:109126
increased interleukin-12b secretion J:109126
increased susceptibility to parasitic infection J:109126
lung inflammation J:109126
small intestinal inflammation J:109126
Lgals3tm1Ftl/Lgals3tm1Ftl
involves: 129S2/SvPas * C57BL/6
abnormal leukocyte physiology J:60741
abnormal macrophage physiology J:60741
abnormal monocyte morphology J:60741
abnormal seminiferous tubule morphology J:313172
abnormal Sertoli cell development J:313172
abnormal spermatogenesis J:313172
abnormal testis physiology J:313172
decreased lymphocyte cell number J:60741
decreased macrophage cell number J:60741, J:313172
decreased male germ cell number J:313172
decreased monocyte cell number J:60741
decreased testis weight J:313172
increased circulating testosterone level J:313172
increased eosinophil cell number J:60741
increased macrophage apoptosis J:60741
increased male germ cell apoptosis J:313172
peritoneal inflammation J:60741
testicular atrophy J:313172
Lgals3tm1Ftl/Lgals3tm1Ftl
involves: 129S2/SvPas * CD-1
abnormal hepatocyte morphology J:116073
abnormal liver morphology J:116073, J:221030
focal hepatic necrosis J:116073, J:221030
hepatic steatosis J:116073, J:221030
increased circulating alanine transaminase level J:116073
increased hepatocellular carcinoma incidence J:221030
increased liver triglyceride level J:116073
increased liver weight J:116073
liver fibrosis J:221030
liver inflammation J:221030
Mallory bodies J:116073
oxidative stress J:116073
Lgals3tm1Poi/Lgals3tm1Poi
B6.Cg-Lgals3tm1Poi/J
abnormal circadian behavior J:264129
abnormal stationary movement J:264129
decreased locomotor activity J:264129
increased body weight J:264129
increased bone mineral density J:264129
increased total body fat amount J:264129
Lgals3tm1Poi/Lgals3tm1Poi
involves: 129 * C57BL/6J * SJL
normal integument phenotype J:47227
normal mortality/aging J:47227
normal reproductive system phenotype J:47227
Lgals3tm1Poi/Lgals3tm1Poi
involves: 129/Sv * C57BL/6 * MF1 * SJL
decreased granulocyte number J:110422
Lgals3tm1Poi/Lgals3tm1Poi
involves: 129/Sv * C57BL/6 * SJL
abnormal kidney physiology J:131371
abnormal long bone epiphyseal plate morphology J:66902
abnormal long bone hypertrophic chondrocyte zone J:66902
abnormal macrophage physiology J:131971
decreased susceptibility to injury J:131371
decreased width of hypertrophic chondrocyte zone J:66902
impaired macrophage chemotaxis J:131971
impaired macrophage phagocytosis J:131407
impaired neutrophil recruitment J:131407
increased interleukin-6 secretion J:131407
increased susceptibility to bacterial infection J:131407
increased susceptibility to induced morbidity/mortality J:131407
increased tumor necrosis factor secretion J:131407
lung inflammation J:131407
sepsis J:131407
Lgals3tm1Poi/Lgals3tm1Poi
involves: 129S/SvEv
abnormal social/conspecific interaction behavior J:217719
aggression towards inanimate objects J:217719
impaired cued conditioning behavior J:217719

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory