Lgals3^tm1Poi
Targeted Allele Detail

Summary

• Symbol: Lgals3^tm1Poi
• Name: lectin, galactose binding, soluble 3; targeted mutation 1, Francoise Poirier
• MGI ID: MGI:2183057
• Synonyms: GaL3^-, galectin 3^-
• Gene: Lgals3 Location: Chr14:47611317-47623624 bp, + strand Genetic Position: Chr14, 24.6 cM, cytoband C1
• Alliance: Lgals3^tm1Poi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47227
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 3.7kb of sequence, encompassing exons 2 through 4, was replaced via the insertion of a neomycin selection cassette. Immunostaining of fetal skin showed an absence of protein in homozygous mutant embryos. (J:47227)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Lgals3 Mutation: 26 strains or lines available

References

• Original: J:47227 Colnot C, et al., Embryonic implantation in galectin 1/galectin 3 double mutant mice. Dev Dyn. 1998 Apr;211(4):306-13
• All: 75 reference(s)