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Lgals3tm1Ftl
Targeted Allele Detail
Summary
Symbol: Lgals3tm1Ftl
Name: lectin, galactose binding, soluble 3; targeted mutation 1, Fu-Tong Liu
MGI ID: MGI:2386938
Synonyms: gal3-, Gal-3-, Lgals3-
Gene: Lgals3  Location: Chr14:47611317-47623624 bp, + strand  Genetic Position: Chr14, 24.6 cM, cytoband C1
Alliance: Lgals3tm1Ftl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60741
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe carbohydrate-binding domain coding region was disrupted by replacing 0.5 kb of genomic sequences at the intron 4-exon 5 junction with a neomycin resistance cassette. Western blot analysis of several organ samples from homozygous mutant mice confirmed the absence of protein expression. (J:60741)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Lgals3 Mutation:  22 strains or lines available
References
Original:  J:60741 Hsu DK, et al., Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses. Am J Pathol. 2000 Mar;156(3):1073-83
All:  86 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory