125 phenotypes from 9 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mecomem1(IMPC)J/Mecom+ C57BL/6NJ-Mecomem1(IMPC)J/Mmjax	thrombocytopenia	J:211773
Mecomem1(IMPC)J/Mecomem1(IMPC)J C57BL/6NJ-Mecomem1(IMPC)J/Mmjax	preweaning lethality, complete penetrance	J:211773
MecomJbo/Mecom+ C3N.C-MecomJbo	abnormal craniofacial morphology	J:90559
	abnormal neutrophil differentiation	J:113445
	abnormal tympanic membrane morphology	J:113445
	deafness	J:90559, J:113445
	decreased body weight	J:90559
	normal immune system phenotype	J:113445
	increased miscarriage rate	J:113445
	increased susceptibility to otitis media	J:113445
	polydactyly	J:90559, J:113445
	respiratory system inflammation	J:113445
	tympanic membrane perforation	J:113445
MecomJbo/Mecom+ involves: BALB/c	abnormal pinna reflex	J:250208
	normal hearing/vestibular/ear phenotype	J:250208
	impaired hearing	J:250208
	increased susceptibility to otitis media	J:250208
	middle ear effusion	J:250208
	middle ear polyps	J:250208
MecomJbo/MecomJbo C3N.C-MecomJbo	abnormal forebrain morphology	J:113445
	abnormal limb development	J:113445
	brachydactyly	J:113445
	distended pericardium	J:113445
	embryonic lethality during organogenesis, incomplete penetrance	J:113445
	perinatal lethality, incomplete penetrance	J:113445
	polydactyly	J:113445
MecomJbo/Mecomtm1Mmor involves: 129S2/SvPas * BALB/c * C3H/HeN * CF-1	perinatal lethality, complete penetrance	J:113445
Mecomtm1.1Miku/Mecom+ B6.Cg-Mecomtm1.1Miku	abnormal hematopoietic stem cell morphology	J:149794
	abnormal platelet morphology	J:149794
	decreased hematopoietic stem cell number	J:149794
Mecomtm1.1Miku/Mecom+ involves: C57BL/6NCrlj * CBA/JNCrlj	abnormal hematopoietic stem cell physiology	J:178616
	decreased hematopoietic stem cell number	J:178616
Mecomtm1.1Miku/Mecomtm1.1Miku B6.Cg-Mecomtm1.1Miku	abnormal fetal liver hematopoietic progenitor cell morphology	J:149794
	abnormal hematopoietic stem cell morphology	J:149794
	abnormal vitelline vasculature morphology	J:149794
	decreased hematopoietic stem cell number	J:149794
	hemorrhage	J:149794
	lethality throughout fetal growth and development, complete penetrance	J:149794
	pale yolk sac	J:149794
	skin edema	J:149794
Mecomtm1Aspe/Mecomtm1Aspe involves: 129S6/SvEvTac * C57BL/6	abnormal bone collagen fibril morphology	J:207915
	abnormal bone marrow cell morphology/development	J:178429
	abnormal common myeloid progenitor cell morphology	J:178429
	abnormal hematopoietic stem cell physiology	J:178429
	abnormal intervertebral disk morphology	J:207915
	abnormal ligament morphology	J:207915
	abnormal limb posture	J:207915
	abnormal lumbar vertebrae morphology	J:207915
	abnormal sacrum morphology	J:207915
	abnormal spine curvature	J:207915
	abnormal tail position or orientation	J:207915
	abnormal tendon collagen fibril morphology	J:207915
	abnormal vertebral articular process morphology	J:207915
	abnormal vertebral transverse process morphology	J:207915
	absent nucleus pulposus	J:207915
	caudal vertebral fusion	J:207915
	decreased body size	J:178429, J:207915
	decreased body weight	J:207915
	decreased bone mineral density	J:207915
	decreased bone strength	J:207915
	decreased bone trabecula number	J:207915
	decreased hematopoietic stem cell number	J:178429
	decreased trabecular bone connectivity density	J:207915
	decreased trabecular bone thickness	J:207915
	decreased trabecular bone volume	J:207915
	delayed endochondral bone ossification	J:207915
	exostosis	J:207915
	normal hematopoietic system phenotype	J:178429
	normal homeostasis/metabolism phenotype	J:207915
	increased bone trabecular spacing	J:207915
	increased leukocyte cell number	J:178429
	increased susceptibility to xenobiotic induced morbidity/mortality	J:178429
	intervertebral disk degeneration	J:207915
	kyphoscoliosis	J:207915
	kyphosis	J:178429
	lordokyphosis	J:207915
	lordosis	J:207915
	lumbar vertebral fusion	J:207915
	malocclusion	J:178429
	normal neoplasm	J:178429
	postnatal growth retardation	J:178429, J:207915
	reduced female fertility	J:207915
	reduced fertility	J:207915
	reduced male fertility	J:207915
	sacral vertebral fusion	J:207915
	normal skeleton phenotype	J:207915
	slow postnatal weight gain	J:207915
	thrombocytopenia	J:178429
	vertebral fusion	J:207915
Mecomtm1Aspe/Mecomtm1Mmor involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6	lethality, complete penetrance	J:178429
Mecomtm1Aspe/Mecomtm2.1Aspe Tg(CAG-cre/Esr1*)5Amc/0 involves: 129S1/SvImJ * C57BL/6 * C57BL/6J * CBA	abnormal bone marrow cell morphology/development	J:178429
	abnormal common myeloid progenitor cell morphology	J:178429
	decreased common myeloid progenitor cell number	J:178429
Mecomtm1Miku/Mecom+ Tg(Tek-cre)12Flv/0 involves: C3H * C57BL/6 * CBA	decreased hematopoietic stem cell number	J:149794
Mecomtm1Miku/Mecomtm1Miku Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	abnormal hematopoietic stem cell morphology	J:149794
	abnormal platelet morphology	J:149794
	decreased hematopoietic stem cell number	J:149794
	thrombocytopenia	J:149794
Mecomtm1Miku/Mecomtm1Miku Tg(Tek-cre)12Flv/0 involves: C3H * C57BL/6 * CBA	decreased hematopoietic stem cell number	J:149794
	hemorrhage	J:149794
	lethality throughout fetal growth and development, incomplete penetrance	J:149794
	skin edema	J:149794
Mecomtm1Mmor/Mecomtm1Mmor involves: 129S2/SvPas * CF-1	abnormal amnion morphology	J:42030
	abnormal cranial ganglia morphology	J:42030
	abnormal diencephalon morphology	J:42030
	abnormal heart looping	J:42030
	abnormal liver bud morphology	J:42030
	abnormal mesonephros morphology	J:42030
	abnormal myotome development	J:42030
	abnormal pharyngeal arch morphology	J:42030
	abnormal spinal nerve morphology	J:42030
	abnormal superior glossopharyngeal ganglion morphology	J:42030
	abnormal superior vagus ganglion morphology	J:42030
	absent hindlimb buds	J:42030
	absent myotome	J:42030
	absent paraxial mesoderm	J:42030
	absent sclerotome	J:42030
	decreased embryo size	J:42030
	embryonic lethality during organogenesis, complete penetrance	J:42030
	enlarged pericardium	J:42030
	hemorrhage	J:42030
	incomplete somite formation	J:42030
	normal nervous system phenotype	J:42030
	pale placenta	J:42030
	pale yolk sac	J:42030
	pharyngeal arch hypoplasia	J:42030
	small embryonic telencephalon	J:42030
	small forelimb buds	J:42030
	small trigeminal ganglion	J:42030
	trabecula carnea hypoplasia	J:42030
Mecomtm2.1Aspe/Mecomtm2.1Aspe Tg(CAG-cre/Esr1*)5Amc/0 involves: 129S1/SvImJ * C57BL/6 * CBA	abnormal bone marrow cell morphology/development	J:178429
	abnormal common myeloid progenitor cell morphology	J:178429
	decreased common myeloid progenitor cell number	J:178429
Mecomtm2.2Aspe/Mecomtm2.2Aspe involves: 129 * C57BL/6J * FVB/N	abnormal heart morphology	J:213829
	abnormal immune system organ morphology	J:213829
	decreased B cell number	J:213829
	decreased hematopoietic precursor cell number	J:213829
	decreased hematopoietic stem cell number	J:213829
	decreased leukocyte cell number	J:213829
	double outlet right ventricle	J:213829
	edema	J:213829
	hemorrhage	J:213829
	interrupted aortic arch	J:213829
	overriding aortic valve	J:213829
	persistent truncus arteriosus	J:213829
	postnatal lethality, complete penetrance	J:213829
	pulmonary vascular congestion	J:213829
	thrombocytopenia	J:213829
	ventricular septal defect	J:213829
	weakness	J:213829
	weight loss	J:213829
Mecomtm2Miku/Mecom+ involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	no abnormal phenotype detected	J:178616