Mecom^Jbo
Chemically induced Allele Detail

Summary

• Symbol: Mecom^Jbo
• Name: MDS1 and EVI1 complex locus; Junbo
• MGI ID: MGI:2158381
• Synonyms: Evi1^Jbo, GENA251, Jbo, Junbo
• Gene: Mecom Location: Chr3:30005445-30563937 bp, - strand Genetic Position: Chr3, 12.66 cM
• Alliance: Mecom^Jbo page

Polydactyly in Mecom^Jbo/Evi1⁺ and Mecom^Jbo/Mecom^Jbo mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: BALB/c
• Project Collection: Harwell ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation was shown by sequence analysis to be an A2288T transversion in the gene causing a nonconservative Asn763Ile change in the second of the two zinc-finger domains in the encoded protein. (J:113445)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mecom Mutation: 81 strains or lines available

References

• Original: J:113445 Parkinson N, et al., Mutation at the Evi1 locus in Junbo mice causes susceptibility to Otitis media. PLoS Genet. 2006;2(10):e149
• All: 14 reference(s)