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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		App
amyloid beta precursor protein
MGI:88059
91 phenotypes from 31 alleles in 28 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Apptm1.1Cep/App+
involves: 129S1/Sv * 129X1/SvJ 		abnormal cell physiology J:35500
Apptm1.1Cep/Apptm1.1Cep
involves: 129S1/Sv * 129X1/SvJ 		abnormal cell physiology J:35500
Apptm1.1Tcs/Apptm1.1Tcs
involves: C57BL/6 		normal behavior/neurological phenotype J:212758
normal homeostasis/metabolism phenotype J:212758
Apptm1.1Tlyp/Apptm1.1Tlyp
Tg(CAG-cre/Esr1*)5Amc/?
B6.Cg-Apptm1.1Tlyp Tg(CAG-cre/Esr1*)5Amc 		abnormal stratification in cerebral cortex J:241006
Apptm1.1Wevn/Apptm1.1Wevn
B6.129S6(FVB)-Apptm1.1Wevn 		hematoma J:241632
increased susceptibility to induced thrombosis J:241632
intracerebral hemorrhage J:241632
Apptm1.2Tlyp/Apptm1.2Tlyp
B6.129S4(Cg)-Apptm1.2Tlyp 		normal nervous system phenotype J:241006
Apptm1b(KOMP)Wtsi/App+
C57BL/6N-Apptm1b(KOMP)Wtsi/Ics 		decreased grip strength J:211773
decreased total retina thickness J:211773
increased blood urea nitrogen level J:211773
increased circulating calcium level J:211773
increased cornea thickness J:211773
short tibia J:211773
Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
C57BL/6N-Apptm1b(KOMP)Wtsi/Ics 		preweaning lethality, incomplete penetrance J:211773
Apptm1Cep/App+
involves: 129S1/Sv * 129X1/SvJ 		abnormal cell physiology J:35500
Apptm1Cep/Apptm1Cep
involves: 129S1/Sv * 129X1/SvJ 		abnormal cell physiology J:35500
Apptm1Ck/Apptm1Ck
involves: 129 		abnormal brain morphology J:191170
increased anxiety-related response J:191170
Apptm1Cwe/Apptm1Cwe
129S-Apptm1Cwe 		abnormal brain commissure morphology J:54584
absent corpus callosum J:54584
decreased anterior commissure size J:54584
decreased brain weight J:54584
decreased hippocampal commissure size J:54584
Apptm1Cwe/Apptm1Cwe
B6.129S2-Apptm1Cwe 		abnormal brain commissure morphology J:54584
decreased anterior commissure size J:54584
decreased brain weight J:54584
decreased corpus callosum size J:54584
decreased hippocampal commissure size J:54584
Apptm1Cwe/Apptm1Cwe
involves: 129S2/SvPas 		abnormal circadian behavior J:123316
abnormal emotion/affect behavior J:123316
abnormal locomotor activation J:123316
abnormal motor capabilities/coordination/movement J:123316
abnormal spatial learning J:123316
decreased body weight J:123316
decreased brain weight J:123316
decreased exploration in new environment J:123316
decreased grip strength J:123316
impaired swimming J:123316
increased thigmotaxis J:123316
reduced long-term potentiation J:123316
Apptm1Cwe/Apptm1Cwe
involves: 129S2/SvPas * C57BL/6 		abnormal brain commissure morphology J:54584
abnormal cued conditioning behavior J:21937
abnormal fear/anxiety-related behavior J:21937
abnormal learning/memory/conditioning J:21937
abnormal spatial reference memory J:21937
absent corpus callosum J:21937
decreased anterior commissure size J:54584
decreased body weight J:21937
decreased brain weight J:54584
decreased exploration in new environment J:21937
decreased hippocampal commissure size J:54584
increased thigmotaxis J:21937
normal nervous system phenotype J:54584
Apptm1Dbo/Apptm1Dbo
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal active avoidance behavior J:53824
abnormal locomotor activation J:25512
abnormal long-term potentiation J:53824
abnormal neuron morphology J:53824
abnormal spatial learning J:53824
astrocytosis J:53824
decreased body weight J:25512
decreased grip strength J:25512
decreased locomotor activity J:53824
gliosis J:25512
hematoma J:241632
increased susceptibility to induced thrombosis J:241632
intracerebral hemorrhage J:241632
Apptm1Ini/App+
involves: C57BL/6 * CBA * CD-1 		abnormal learning/memory/conditioning J:90296
abnormal locomotor behavior J:90296
abnormal long-term object recognition memory J:90296
abnormal spatial learning J:90296
abnormal telencephalon morphology J:90296
amyloid beta deposits J:90296
increased locomotor activity J:90296
premature death J:90296
Apptm1Somm/Apptm1Somm
C57BL/6-Apptm1Somm 		abnormal excitatory postsynaptic currents J:276486
decreased body weight J:127367
decreased grip strength J:127367
decreased locomotor activity J:127367
impaired passive avoidance behavior J:127367
Apptm1Tsuz/Apptm1Tsuz
involves: C57BL/6 		normal nervous system phenotype J:116283, J:129354
Apptm2.1Ldad/Apptm2.1Ldad
involves: 129 * C57BL/6J 		centrally nucleated skeletal muscle fibers J:166989
increased variability of skeletal muscle fiber size J:166989
muscle degeneration J:166989
myositis J:166989
normal nervous system phenotype J:166989
Apptm2.1Tcs/Apptm2.1Tcs
involves: C57BL/6 		abnormal learning/memory/conditioning J:212758
abnormal synapse morphology J:212758
amyloid beta deposits J:212758
amyloidosis J:212758
astrocytosis J:212758
microgliosis J:212758
Apptm2.1Zhe/Apptm2.1Zhe
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:165417
Apptm2Cwe/Apptm2Cwe
involves: 129P2/OlaHsd * 129S/SvEv 		abnormal brain commissure morphology J:54584
absent corpus callosum J:54584
decreased anterior commissure size J:54584
decreased brain weight J:54584
decreased hippocampal commissure size J:54584
Apptm2Cwe/Apptm2Cwe
involves: 129P2/OlaHsd * C57BL/6 		abnormal brain commissure morphology J:54584
decreased brain weight J:54584
decreased corpus callosum size J:54584
decreased hippocampal commissure size J:54584
Apptm2Umu/Apptm2Umu
involves: 129P2/OlaHsd * C57BL/6 		normal behavior/neurological phenotype J:123316
decreased brain weight J:123316
normal growth/size/body region phenotype J:123316
normal nervous system phenotype J:123316
Apptm3.1Tcs/Apptm3.1Tcs
involves: C57BL/6 		abnormal learning/memory/conditioning J:212758
abnormal synapse morphology J:212758
amyloid beta deposits J:212758
amyloidosis J:212758
astrocytosis J:212758
microgliosis J:212758
Apptm3.1Tcs/Apptm3.1Tcs
Not Specified 		amyloid beta deposits J:261970
astrocytosis J:261970
Apptm3.1Umu/Apptm3.1Umu
involves: 129P2/OlaHsd * C57BL/6N 		no abnormal phenotype detected J:163059
Apptm3.1Zhe/Apptm3.1Zhe
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:166379
Apptm3.2Umu/Apptm2Cwe
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6N 		decreased body weight J:163059
decreased brain weight J:163059
decreased grip strength J:163059
Tg(App)1874Kha/?
FVB/N-Tg(App)1874Kha 		abnormal anxiety-related response J:29880
abnormal astrocyte morphology J:29880
premature death J:29880
Tg(APP-App*R609D*K612E)7Vln/0
involves: FVB 		abnormal neuron morphology J:32213
increased neuron apoptosis J:32213
neuron degeneration J:32213
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)18Dbo/0
involves: C3H/HeJ * C57BL/6 * CBA 		abnormal nervous system physiology J:109829
amyloid beta deposits J:109829
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)102Dbo/0
involves: C3H/HeJ * C57BL/6 * CBA 		abnormal nervous system physiology J:109829
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)107Dbo/0
(FVB/NJ x B6.Cg-Tg(tetO-APPSwInd)107Dbo Tg(Camk2a-tTA)1Mmay)F1 		abnormal long-term spatial reference memory J:195259
amyloid beta deposits J:195259
normal behavior/neurological phenotype J:195259
impaired spatial working memory J:195259
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)107Dbo/0
involves: C3H/HeJ * C57BL/6 * CBA 		abnormal astrocyte morphology J:109829
abnormal circadian behavior J:109829
abnormal dentate gyrus morphology J:185792
abnormal locomotor activation J:109829
abnormal nervous system physiology J:109829
amyloid beta deposits J:109829
CNS inflammation J:109829
hippocampal neuron degeneration J:185792
increased locomotor activity J:109829
neurofibrillary tangles J:109829
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)Dbo/0
involves: C3H/HeJ * C57BL/6J 		abnormal astrocyte morphology J:236737
abnormal axon initial segment morphology J:236737
amyloid beta deposits J:236737
axon degeneration J:236737
microgliosis J:236737
Tg(Gng8-tTA)#Ryba/0
Tg(tetO-APPSwInd)Dbo/0
involves: 129 * C3H/HeJ * C57BL/6J * FVB/N 		abnormal olfactory epithelium morphology J:176127
abnormal olfactory sensory neuron physiology J:176127
decreased olfactory sensory neuron number J:176127
neurodegeneration J:176127
Tg(tetO-APPSwInd)Dbo/0
involves: C3H/HeJ * C57BL/6J 		abnormal axonal transport J:207508
Tg(Thy1-App*R609D*K612E)2Vln/0
involves: C57BL * CBA/J 		abnormal microglial cell morphology J:32213
abnormal neuron morphology J:32213
astrocytosis J:32213
gliosis J:32213
increased neuron apoptosis J:32213
neuron degeneration J:32213
premature death J:32213
seizures J:32213
Tg(Thy1-App*R609D*K612E)4Vln/0
involves: FVB 		abnormal astrocyte morphology J:32213
abnormal locomotor activation J:32213
abnormal microglial cell morphology J:32213
abnormal neuron morphology J:32213
abnormal respiration J:32213
abnormal response to new environment J:32213
astrocytosis J:32213
behavioral arrest J:32213
clonic seizures J:32213
facial muscle spasm J:32213
gliosis J:32213
increased neuron apoptosis J:32213
increased thigmotaxis J:32213
lethargy J:32213
myoclonus J:32213
neuron degeneration J:32213
premature death J:32213
seizures J:32213
tonic-clonic seizures J:32213
Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
involves: FVB 		abnormal locomotor activation J:32213
abnormal respiration J:32213
abnormal response to new environment J:32213
behavioral arrest J:32213
clonic seizures J:32213
decreased susceptibility to pharmacologically induced seizures J:32213
facial muscle spasm J:32213
increased aggression towards mice J:32213
increased susceptibility to pharmacologically induced seizures J:32213
increased thigmotaxis J:32213
lethargy J:32213
myoclonus J:32213
premature death J:32213
seizures J:32213
tonic-clonic seizures J:32213
Tg(Thy1-App*R609D*K612E)6Vln/0
involves: FVB 		abnormal astrocyte morphology J:32213
abnormal locomotor activation J:32213
abnormal microglial cell morphology J:32213
abnormal neuron morphology J:32213
abnormal respiration J:32213
abnormal response to new environment J:32213
astrocytosis J:32213
behavioral arrest J:32213
clonic seizures J:32213
facial muscle spasm J:32213
gliosis J:32213
increased thigmotaxis J:32213
lethargy J:32213
myoclonus J:32213
neuron degeneration J:32213
premature death J:32213
seizures J:32213
tonic-clonic seizures J:32213
Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
involves: FVB 		abnormal locomotor activation J:32213
abnormal respiration J:32213
abnormal response to new environment J:32213
behavioral arrest J:32213
clonic seizures J:32213
decreased susceptibility to pharmacologically induced seizures J:32213
facial muscle spasm J:32213
increased aggression towards mice J:32213
increased susceptibility to pharmacologically induced seizures J:32213
increased thigmotaxis J:32213
lethargy J:32213
myoclonus J:32213
premature death J:32213
seizures J:32213
tonic-clonic seizures J:32213
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory