App^tm1Somm
Targeted Allele Detail

Summary

• Symbol: App^tm1Somm
• Name: amyloid beta precursor protein; targeted mutation 1, Bernd Sommer
• MGI ID: MGI:3764842
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^tm1Somm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127786
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A stop codon was inserted into exon 1. Absence of protein product was confirmed by westrn blot analysis on protein extracts from the hippocampus. (J:127367)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any App Mutation: 89 strains or lines available

References

• Original: J:127786 Lorenzo A, et al., Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease. Nat Neurosci. 2000 May;3(5):460-4
• All: 3 reference(s)