98 phenotypes from 13 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Foxo1tm1.1Dac/Foxo1tm1.1Dac Not Specified	abnormal blood vessel morphology	J:179687
	abnormal dorsal aorta morphology	J:179687
	abnormal embryo development	J:179687
	abnormal heart development	J:179687
	abnormal heart morphology	J:179687
	abnormal myocardial trabeculae morphology	J:179687
	abnormal somite development	J:179687
	abnormal somite shape	J:179687
	abnormal vitelline vasculature morphology	J:179687
	absent heartbeat	J:179687
	absent second pharyngeal arch	J:179687
	decreased somite size	J:179687
	embryonic growth retardation	J:179687
	enlarged pericardium	J:179687
	preweaning lethality, complete penetrance	J:179687
	small first pharyngeal arch	J:179687
	small second pharyngeal arch	J:179687
Foxo1tm1.1Mrc/Foxo1tm1.1Mrc involves: 129S1/Sv * 129X1/SvJ	embryonic lethality, complete penetrance	J:93444
Foxo1tm1.1Rdp/Foxo1tm1.1Rdp involves: 129S1/Sv * FVB/N	embryonic lethality during organogenesis, complete penetrance	J:118179
Foxo1tm1.1Stlp/Foxo1tm1.1Stlp Tg(Lck-cre)1Cwi/0 involves: 129S4/SvJae	abnormal single-positive T cell number	J:154205
	decreased CD8-positive, alpha-beta T cell number	J:154205
	decreased double-positive T cell number	J:154205
	decreased T cell number	J:154205
	decreased T cell proliferation	J:154205
	decreased thymocyte apoptosis	J:154205
	increased CD4-positive, alpha-beta T cell number	J:154205
	increased CD8-positive, alpha-beta T cell number	J:154205
	small lymphoid organs	J:154205
	small spleen	J:154205
Foxo1tm1b(EUCOMM)Wtsi/Foxo1+ C57BL/6N-Foxo1tm1b(EUCOMM)Wtsi/J	decreased erythrocyte cell number	J:211773
	hyperactivity	J:211773
	increased circulating bilirubin level	J:211773
	increased mean corpuscular volume	J:211773
Foxo1tm1b(EUCOMM)Wtsi/Foxo1tm1b(EUCOMM)Wtsi C57BL/6N-Foxo1tm1b(EUCOMM)Wtsi/J	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Foxo1tm1Flv/Foxo1tm1Flv Foxp3tm4(YFP/icre)Ayr/Foxp3+ involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ	abnormal inflammatory response	J:189962
	abnormal regulatory T cell physiology	J:189962
	abnormal skin appearance	J:189962
	abnormal tail morphology	J:189962
	enlarged lymph nodes	J:189962
	enlarged spleen	J:189962
	hunched posture	J:189962
	increased CD4-positive, alpha-beta T cell number	J:189962
	increased CD8-positive, alpha-beta T cell number	J:189962
	increased interferon-gamma secretion	J:189962
	increased regulatory T cell number	J:189962
	increased T cell number	J:189962
	increased T cell proliferation	J:189962
	paralysis	J:189962
	premature death	J:189962
Foxo1tm1Flv/Foxo1tm1Flv Ndor1Tg(UBC-cre/ERT2)1Ejb/0 involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6	increased interferon-gamma secretion	J:189962
Foxo1tm1Flv/Foxo1tm1Flv Tg(Cd4-cre)1Cwi/? involves: 129S6/SvEvTac * C57BL/6 * DBA/2	abnormal CD4-positive, alpha-beta T cell physiology	J:147057
	abnormal CD8-positive, alpha-beta T cell physiology	J:147057
	abnormal T cell activation	J:147057
	abnormal T cell physiology	J:147057
	enlarged lymph nodes	J:147057
	increased anti-double stranded DNA antibody level	J:147057
	increased anti-nuclear antigen antibody level	J:147057
	increased single-positive T cell number	J:147057
	increased susceptibility to induced colitis	J:147057
	increased T cell proliferation	J:147057
Foxo1tm1Mrc/Foxo1tm1Mrc involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:93444
Foxo1tm1Rdp/Foxo1tm1.1Rdp Tg(Col1a1-cre)1Kry/0 involves: 129S1/Sv * FVB	normal homeostasis/metabolism phenotype	J:199264
Foxo1tm1Rdp/Foxo1tm1Rdp Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129S1/Sv * C57BL/6 * DBA * FVB	improved glucose tolerance	J:137845
Foxo1tm1Rdp/Foxo1tm1Rdp Tg(Mx1-cre)1Cgn/0 involves: 129S1/Sv * C57BL/6 * CBA * FVB/N	increased hemangioma incidence	J:118179
	premature death	J:118179
Foxo1tm1Tf/Foxo1tm1Tf involves: C57BL/6J	abnormal dorsal aorta morphology	J:92247
	abnormal visceral yolk sac morphology	J:92247
	abnormal vitelline vascular remodeling	J:92247
	absent organized vascular network	J:92247
	absent second pharyngeal arch	J:92247
	embryonic growth retardation	J:92247
	embryonic lethality during organogenesis, complete penetrance	J:92247
	pericardial effusion	J:92247
	pharyngeal arch artery hypoplasia	J:92247
	pharyngeal arch hypoplasia	J:92247
	small first pharyngeal arch	J:92247
Foxo1tm1Whb/Foxo1+ Not Specified	decreased liver glycogen level	J:79560
Foxo1tm1Whb/Foxo1tm1Whb Not Specified	abnormal internal carotid artery morphology	J:88638
	abnormal intersomitic vessel morphology	J:88638
	absent vitelline blood vessels	J:88638
	delayed heart looping	J:88638
	distended pericardium	J:88638
	embryonic lethality during organogenesis, complete penetrance	J:88638
Foxo1tm2.1Dac/Foxo1tm2.1Dac B6.Cg-Foxo1tm2.1Dac	decreased circulating tumor necrosis factor level	J:179687
	decreased liver cholesterol level	J:179687
	increased percent body fat/body weight	J:179687
	increased susceptibility to diet-induced obesity	J:179687
Foxo1tm2.1Dac/Foxo1tm2.1Dac Not Specified	abnormal adipose tissue physiology	J:179687
	abnormal gluconeogenesis	J:179687
	abnormal glucose homeostasis	J:179687
	abnormal lipid homeostasis	J:179687
	decreased carbon dioxide production	J:179687
	decreased circulating cholesterol level	J:179687
	decreased circulating free fatty acids level	J:179687
	decreased circulating triglyceride level	J:179687
	decreased circulating VLDL triglyceride level	J:179687
	decreased energy expenditure	J:179687
	decreased liver triglyceride level	J:179687
	decreased respiratory quotient	J:179687
	increased circulating glucose level	J:179687
	increased circulating insulin level	J:179687
	insulin resistance	J:179687
Tg(Ttr-Foxo1)305Dac/0 involves: FVB * C57BL/6	abnormal pancreatic beta cell morphology	J:79560
	decreased circulating insulin level	J:79560
	hyperglycemia	J:79560
	impaired glucose tolerance	J:79560
	insulin resistance	J:79560
Tg(Ttr-Foxo1)307Dac/0 involves: C57BL/6J	increased circulating cholesterol level	J:94423
	increased circulating HDL cholesterol level	J:94423
	increased circulating triglyceride level	J:94423
Tg(Ttr-Foxo1)307Dac/0 involves: FVB * C57BL/6	abnormal pancreatic beta cell morphology	J:79560
	hyperglycemia	J:79560
	impaired glucose tolerance	J:79560
	increased circulating insulin level	J:79560
	increased insulin sensitivity	J:79560