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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lcp2
lymphocyte cytosolic protein 2
MGI:1321402
29 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cbltm1.1Hua/Cbltm1.1Hua
Lcp2tm1Gak/Lcp2tm1Gak
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal cytokine secretion J:91369
abnormal T cell differentiation J:91369
enlarged spleen J:91369
increased CD4-positive, alpha-beta T cell number J:91369
liver inflammation J:91369
lung inflammation J:91369
Cbltm1.1Hua/Cbltm1.1Hua
Lcp2tm1Gak/Lcp2tm1Gak
Rag2tm1Fwa/Rag2tm1Fwa
involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ 		abnormal T cell differentiation J:91369
Clnktm1Rygo/Clnktm1Rygo
Lcp2tm1Geha/Lcp2tm1Geha
involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c 		decreased interferon-gamma secretion J:131621
impaired natural killer cell mediated cytotoxicity J:131621
increased NK cell number J:131621
Grap2tm1Amch/Grap2tm1Amch
Lcp2tm1.1Wz/Lcp2tm1.1Wz
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal T cell differentiation J:150304
decreased CD4-positive, alpha-beta T cell number J:150304
decreased CD8-positive, alpha-beta T cell number J:150304
decreased double-positive T cell number J:150304
decreased single-positive T cell number J:150304
Lattm1Les/Lattm1Les
Lcp2tm5(Lat/Lcp2)Gak/Lcp2tm5(Lat/Lcp2)Gak
involves: 129S1/Sv * 129X1/SvJ 		arrested T cell differentiation J:147721
decreased double-positive T cell number J:147721
Lcp2tm1.1Wz/Lcp2tm1.1Wz
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: C57BL/6 * C57BL/6J * DBA/2J 		abnormal T cell differentiation J:150304
Lcp2tm1Gak/Lcp2tm2Gak
Tg(Pf4-icre)Q3Rsko/0
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal lymphatic vessel morphology J:162815
abnormal Peyer's patch morphology J:162815
abnormal platelet activation J:162815
Lcp2tm1Gak/Lcp2tm2Gak
Tg(VAV1-cre)1Graf/0
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129X1/SvJ 		abnormal lymphatic vessel morphology J:162815
intestinal edema J:162815
Lcp2tm3Gak/Lcp2tm3Gak
involves: 129S6/SvEvTac * BALB/c * C57BL/6 		abnormal negative T cell selection J:132995
Lcp2tm3Gak/Lcp2tm3Gak
involves: 129S6/SvEvTac * C57BL/6 		abnormal double-negative T cell morphology J:132995
abnormal negative T cell selection J:132995
abnormal T cell activation J:132995
abnormal T cell subpopulation ratio J:132995
decreased NK T cell number J:132995
Lcp2tm3Gak/Lcp2tm3Gak
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129S6/SvEvTac * C57BL/6 * DBA/2J 		abnormal negative T cell selection J:132995
normal immune system phenotype J:132995
increased CD8-positive, alpha-beta T cell number J:132995
increased double-positive T cell number J:132995
Lcp2tm3Gak/Lcp2tm3Gak
Tg(TcrAND)53Hed/?
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal positive T cell selection J:132995
abnormal thymocyte activation J:132995
Lcp2tm3Gak/Lcp2tm4Gak
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		normal immune system phenotype J:132995
Lcp2tm4Gak/Lcp2tm4Gak
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N 		abnormal negative T cell selection J:132995
increased double-positive T cell number J:132995
Lcp2tm4Gak/Lcp2tm4Gak
Tg(TcrAND)53Hed/?
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal positive T cell selection J:132995
abnormal thymocyte activation J:132995
Lcp2tm5(Lat/Lcp2)Gak/Lcp2tm5(Lat/Lcp2)Gak
involves: 129S1/Sv * 129X1/SvJ 		abnormal thymocyte activation J:147721
arrested T cell differentiation J:147721
decreased double-positive T cell number J:147721
decreased single-positive T cell number J:147721
thymus hypoplasia J:147721
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory