Cbl^tm1.1Hua
Targeted Allele Detail

Summary

• Symbol: Cbl^tm1.1Hua
• Name: Cbl proto-oncogene; targeted mutation 1.1, Hua Gu
• MGI ID: MGI:2180576
• Synonyms: c-cbl^-
• Gene: Cbl Location: Chr9:44054273-44145346 bp, - strand Genetic Position: Chr9, 24.72 cM
• Alliance: Cbl^tm1.1Hua page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51666
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The transient expression of cre recombinase within ES cells resulted in the excision of a floxed region containing a neomycin gene and the exon containing nucleotides 681-837 of the published mouse cDNA sequence deposited in GenBank as X57111. The deletion introduced a frameshift mutation. RT-PCR analysis of total RNA extracts from homozygous mutant mice showed an absence of normal transcript. Western analysis using an antibody raised against the C-terminal failed to detect protein in homozygous mutant mice. (J:51666)

Tumor Data

List all tumor models in MMHCdb carrying Cbl^tm1.1Hua

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbl Mutation: 57 strains or lines available

References

• Original: J:51666 Naramura M, et al., Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15547-52
• All: 33 reference(s)