Lcp2^tm1.1Wz
Targeted Allele Detail

Summary

• Symbol: Lcp2^tm1.1Wz
• Name: lymphocyte cytosolic protein 2; targeted mutation 1.1, Weiguo Zhang
• MGI ID: MGI:3850705
• Synonyms: SLP-76^m
• Gene: Lcp2 Location: Chr11:33996928-34042281 bp, + strand Genetic Position: Chr11, 19.43 cM
• Alliance: Lcp2^tm1.1Wz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150304
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced most of the coding region in exon 1 and exons 2 and 3. These exons code for the SAM domain and 3 phosphotyrosine motifs. Two amino acids (Ser and Arg) were added to the modified exon 1 to prevent a frame shift. Germ line, cre mediated recombination removed the neo cassette. (J:150304)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lcp2 Mutation: 41 strains or lines available

References

• Original: J:150304 Shen S, et al., The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation. Blood. 2009 Jul 2;114(1):74-84
• All: 1 reference(s)