Adam17m1Btlr/Adam17m1Btlr
C57BL/6J-Adam17m1Btlr
|
decreased circulating tumor necrosis factor level |
J:166602
|
|
decreased survivor rate |
J:166602
|
|
decreased transforming growth factor beta level |
J:166602
|
|
increased susceptibility to induced colitis |
J:166602
|
|
waved hair |
J:166602
|
|
weight loss |
J:166602
|
Adam17tm1.1Bbl/Adam17tm1.1Bbl
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
|
enlarged aortic valve |
J:221411
|
|
eyelids open at birth |
J:221411
|
|
failure of eyelid fusion |
J:221411
|
|
increased width of hypertrophic chondrocyte zone |
J:221411
|
|
perinatal lethality |
J:221411
|
|
thick aortic valve cusps |
J:221411
|
|
thick pulmonary valve cusps |
J:221411
|
|
thick tricuspid valve cusps |
J:221411
|
Adam17tm1.1Bbl/Adam17tm1.1Bbl
involves: 129P2/OlaHsd * FVB/N
|
abnormal aortic valve morphology |
J:139846
|
|
abnormal pulmonary valve morphology |
J:139846
|
|
abnormal tricuspid valve morphology |
J:139846
|
|
eyelids open at birth |
J:139846
|
|
postnatal lethality, complete penetrance |
J:139846
|
Adam17tm1.1Rain/Adam17tm1.2Rain
Tg(Tek-cre)12Flv/0
B6.Cg-Adam17tm1.1Rain Adam17tm1.2Rain Tg(Tek-cre)12Flv
|
abnormal aortic valve cusp morphology |
J:195050
|
|
abnormal aortic valve flow |
J:195050
|
|
abnormal semilunar valve morphology |
J:195050
|
|
aortic valve stenosis |
J:195050
|
|
decreased cardiac muscle contractility |
J:195050
|
|
enlarged semilunar valve |
J:195050
|
|
increased heart left ventricle size |
J:195050
|
|
increased heart left ventricle weight |
J:195050
|
|
increased heart rate |
J:195050
|
|
increased heart weight |
J:195050
|
|
postnatal lethality, incomplete penetrance |
J:195050
|
|
thick aortic valve cusps |
J:195050
|
Adam17tm1.1Srj/Adam17tm1.1Srj
involves: 129S/SvEv
|
abnormal platelet physiology |
J:165863
|
Adam17tm1.1Srj/Adam17tm1.1Srj
involves: 129S/SvEv * C57BL/6 * SJL
|
abnormal chemokine level |
J:163380
|
|
abnormal enterocyte proliferation |
J:163380
|
|
abnormal interleukin secretion |
J:163380
|
|
abnormal mammary gland duct morphology |
J:163380
|
|
abnormal mitral valve cusp morphology |
J:163380
|
|
normal
digestive/alimentary phenotype |
J:163380
|
|
distorted hair follicle pattern |
J:163380
|
|
eye opacity |
J:163380
|
|
eyelids open at birth |
J:163380
|
|
increased heart left ventricle size |
J:163380
|
|
increased interleukin-10 secretion |
J:163380
|
|
increased susceptibility to induced colitis |
J:163380
|
|
increased susceptibility to induced morbidity/mortality |
J:163380
|
|
increased susceptibility to weight loss |
J:163380
|
|
postnatal lethality, incomplete penetrance |
J:163380
|
|
skin inflammation |
J:163380
|
Adam17tm1.1Wesh/Adam17tm1.1Wesh
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
|
abnormal myocardial trabeculae morphology |
J:210193
|
|
abnormal myocardium layer morphology |
J:210193
|
|
enlarged heart |
J:210193
|
|
normal
mortality/aging |
J:210193
|
|
thin myocardium |
J:210193
|
Adam17tm1.1Wesh/Adam17tm1.1Wesh
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * C57BL/6 * FVB/N
|
abnormal lung epithelium morphology |
J:210193
|
|
abnormal lung saccule morphology |
J:210193
|
|
abnormal lung vasculature morphology |
J:210193
|
|
decreased cell proliferation |
J:210193
|
|
normal
mortality/aging |
J:210193
|
|
thick lung-associated mesenchyme |
J:210193
|
Adam17tm1.1Wesh/Adam17tm1.1Wesh
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0
Twist2tm1.1(cre)Dor/Twist2+
involves: 129X1/SvJ * C57BL/6 * FVB/N
|
abnormal lung saccule morphology |
J:210193
|
|
abnormal lung vasculature morphology |
J:210193
|
|
decreased cell proliferation |
J:210193
|
|
normal
mortality/aging |
J:210193
|
Adam17tm1.1Wesh/Adam17tm1.1Wesh
Twist2tm1.1(cre)Dor/Twist2+
involves: 129X1/SvJ * C57BL/6 * FVB/N
|
normal
respiratory system phenotype |
J:210193
|
Adam17tm1.2Bbl/Adam17tm1.2Bbl
involves: 129P2/OlaHsd * C57BL/6
|
no abnormal phenotype detected |
J:139846
|
Adam17tm1.2Bbl/Adam17tm1.2Bbl
Sox9tm3(cre)Crm/Sox9+
B6.129(SJL)-Sox9tm3(cre)Crm Adam17tm1.2Bbl
|
abnormal circulating chemokine level |
J:229771
|
|
abnormal epidermal layer morphology |
J:229771
|
|
abnormal skin morphology |
J:229771
|
|
dermatitis |
J:229771
|
|
dry skin |
J:229771
|
|
impaired skin barrier function |
J:229771
|
|
increased IgE level |
J:229771
|
|
increased pruritus |
J:229771
|
|
increased T-helper 1 cell number |
J:229771
|
|
increased T-helper 2 cell number |
J:229771
|
|
increased T-helper 17 cell number |
J:229771
|
Adam17tm1.2Bbl/Adam17tm1.2Bbl
Sox9tm3(cre)Crm/Sox9+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
|
abnormal bone marrow cavity morphology |
J:144795
|
|
abnormal bone remodeling |
J:144795
|
|
abnormal hair growth |
J:144795
|
|
abnormal long bone epiphyseal plate proliferative zone |
J:144795
|
|
abnormal long bone hypertrophic chondrocyte zone |
J:144795
|
|
abnormal skin condition |
J:144795
|
|
abnormal spleen morphology |
J:144795
|
|
decreased B cell number |
J:144795
|
|
decreased body weight |
J:144795
|
|
decreased bone mass |
J:144795
|
|
decreased compact bone thickness |
J:144795
|
|
decreased hematocrit |
J:144795
|
|
decreased length of long bones |
J:144795
|
|
decreased lymphocyte cell number |
J:144795
|
|
decreased T cell number |
J:144795
|
|
decreased trabecular bone thickness |
J:144795
|
|
early eyelid opening |
J:144795
|
|
enlarged spleen |
J:144795
|
|
extramedullary hematopoiesis |
J:144795
|
|
female infertility |
J:144795
|
|
increased bone marrow cell number |
J:144795
|
|
increased circulating interleukin-17 level |
J:144795
|
|
increased hemoglobin content |
J:144795
|
|
increased interleukin-17 secretion |
J:144795
|
|
increased leukocyte cell number |
J:144795
|
|
increased macrophage cell number |
J:144795
|
|
increased neutrophil cell number |
J:144795
|
|
increased spleen red pulp amount |
J:144795
|
|
osteoporosis |
J:144795
|
|
postnatal growth retardation |
J:144795
|
|
premature death |
J:144795
|
|
reduced male fertility |
J:144795
|
|
short femur |
J:144795
|
|
thrombocytosis |
J:144795
|
Adam17tm1.2Rain/Adam17tm1.2Rain
C57BL/6-Adam17tm1.2Rain
|
abnormal atrioventricular valve morphology |
J:195050
|
|
enlarged semilunar valve |
J:195050
|
|
increased heart weight |
J:195050
|
|
perinatal lethality, complete penetrance |
J:195050
|
Adam17tm1.2Wesh/Adam17tm1.2Wesh
involves: 129 * BALB/cJ * C57BL/6 * FVB/N
|
eyelids open at birth |
J:210193
|
|
increased heart ventricle size |
J:210193
|
|
neonatal lethality, incomplete penetrance |
J:210193
|
|
pulmonary hypoplasia |
J:210193
|
Adam17tm1a(EUCOMM)Wtsi/Adam17+
B6JTyr;B6N-Adam17tm1a(EUCOMM)Wtsi/Wtsi
|
abnormal vibrissa morphology |
J:175295
|
|
increased body weight |
J:165965
|
Adam17tm1a(EUCOMM)Wtsi/Adam17+
involves: C57BL/6 * C57BL/6N
|
increased bone mineral content |
J:213427
|
|
increased erythrocyte cell number |
J:213427
|
|
lethality, incomplete penetrance |
J:213427
|
|
myeloid hyperplasia |
J:213427
|
Adam17tm1Bbl/Adam17tm1Bbl
involves: 129P2/OlaHsd
|
no abnormal phenotype detected |
J:139846
|
Adam17tm1Bbl/Adam17tm1Bbl
Lyz2tm1(cre)Ifo/0
involves: 129P2/OlaHsd
|
abnormal macrophage physiology |
J:139846
|
|
decreased circulating tumor necrosis factor level |
J:139846
|
|
decreased susceptibility to endotoxin shock |
J:139846
|
Adam17tm1Bbl/Adam17tm1Bbl
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA
|
decreased circulating tumor necrosis factor level |
J:139846
|
|
decreased susceptibility to endotoxin shock |
J:139846
|
Adam17tm1Ckww/Adam17tm1Ckww
Not Specified
|
abnormal dendritic cell physiology |
J:138782
|
|
normal
mortality/aging |
J:138782
|
Adam17tm1Imx/Adam17tm1Imx
B6.129-Adam17tm1Imx
|
decreased physiological sensitivity to xenobiotic |
J:174865
|
|
enhanced leukocyte tethering or rolling |
J:174865
|
Adam17tm1Imx/Adam17tm1Imx
involves: 129 * C57BL/6
|
abnormal bronchiole epithelium morphology |
J:51053
|
|
abnormal coat/hair pigmentation |
J:51053
|
|
abnormal conjunctival sac morphology |
J:51053
|
|
abnormal cornea morphology |
J:51053
|
|
abnormal embryonic tissue morphology |
J:51053
|
|
abnormal eye morphology |
J:51053
|
|
abnormal fetal cardiomyocyte proliferation |
J:85547
|
|
abnormal hair follicle morphology |
J:51053
|
|
abnormal hair follicle orientation |
J:51053
|
|
abnormal small intestine morphology |
J:51053
|
|
abnormal trabecula carnea morphology |
J:85547
|
|
abnormal trophoblast layer morphology |
J:51053
|
|
curly vibrissae |
J:51053
|
|
decreased body size |
J:51053
|
|
decreased spongiotrophoblast size |
J:51053
|
|
enlarged heart |
J:85547
|
|
eyelids open at birth |
J:51053
|
|
failure of eyelid fusion |
J:51053
|
|
increased heart weight |
J:85547
|
|
increased incidence of corneal inflammation |
J:51053
|
|
increased myocardial fiber size |
J:85547
|
|
perinatal lethality, incomplete penetrance |
J:51053
|
|
premature death |
J:51053
|
|
short vibrissae |
J:51053
|
|
thick aortic valve |
J:99649
|
|
thick ventricular wall |
J:85547
|
|
ventricular septal defect |
J:99649
|
Adam17tm1Imx/Adam17tm1Imx
involves: 129 * C57BL/6J
|
abnormal blood vessel morphology |
J:166217
|
|
abnormal brain vasculature morphology |
J:166217
|
|
decreased body length |
J:166217
|
|
decreased fetal weight |
J:166217
|
|
enlarged aortic valve |
J:83820
|
|
enlarged atrioventricular valve |
J:83820
|
|
enlarged pulmonary valve |
J:83820
|
|
enlarged semilunar valve |
J:83820
|
|
internal hemorrhage |
J:166217
|
|
lethality throughout fetal growth and development, incomplete penetrance |
J:166217
|
|
nuchal edema |
J:166217
|
Adam17tm1Imx/Adam17tm1Imx
involves: 129 * DBA/1J
|
abnormal branching involved in lung morphogenesis |
J:68672
|
|
abnormal lung development |
J:68672
|
|
abnormal lung epithelium morphology |
J:68672
|
|
abnormal lung morphology |
J:68672
|
|
abnormal lung saccule morphology |
J:68672
|
|
abnormal lung vasculature morphology |
J:68672
|
|
abnormal respiratory conducting tube morphology |
J:68672
|
|
cyanosis |
J:68672
|
|
dilated respiratory conducting tube |
J:68672
|
|
eyelids open at birth |
J:68672
|
|
failure of eyelid fusion |
J:68672
|
|
neonatal lethality, complete penetrance |
J:68672
|
|
pale lung |
J:68672
|
|
pulmonary hypoplasia |
J:68672
|
|
respiratory distress |
J:68672
|
|
respiratory failure |
J:68672
|
|
thick lung-associated mesenchyme |
J:68672
|
Adam17tm1Imx/Adam17woe
involves: 129 * C57BL/6
|
abnormal coat/ hair morphology |
J:160781
|
|
abnormal eye morphology |
J:160781
|
|
eyelids open at birth |
J:160781
|
Adam17tm1Rain/Adam17tm1Rain
involves: C57BL/6
|
decreased physiological sensitivity to xenobiotic |
J:174865
|
|
enhanced leukocyte tethering or rolling |
J:174865
|
Adam17tm1Srj/Adam17tm1Srj
involves: 129S/SvEv * C57BL/6
|
premature death |
J:163380
|
Adam17woe/Adam17woe
C57BL/6-Adam17woe
|
abnormal anterior eye segment morphology |
J:160781
|
|
abnormal canal of Schlemm morphology |
J:160781
|
|
abnormal cornea epithelium morphology |
J:160781
|
|
abnormal cornea morphology |
J:160781
|
|
abnormal eyelid margin morphology |
J:160781
|
|
abnormal hair follicle development |
J:160781
|
|
abnormal heart valve morphology |
J:160781
|
|
abnormal retina morphology |
J:160781
|
|
absent cornea endothelium |
J:160781
|
|
absent Descemet membrane |
J:160781
|
|
absent Meibomian glands |
J:160781
|
|
absent Schlemm's canal |
J:160781
|
|
anophthalmia |
J:160781
|
|
anterior iris synechia |
J:160781
|
|
aortic valve hypertrophy |
J:160781
|
|
aphakia |
J:160781
|
|
cataract |
J:160781
|
|
cornea opacity |
J:160781
|
|
cornea scarring |
J:160781
|
|
decreased cornea thickness |
J:160781
|
|
dermatitis |
J:160781
|
|
normal
digestive/alimentary phenotype |
J:160781
|
|
enlarged aortic valve |
J:160781
|
|
enlarged esophagus |
J:156373
|
|
enlarged heart |
J:156373
|
|
enlarged pulmonary valve |
J:160781
|
|
eyelids open at birth |
J:156373,
J:160781
|
|
failure of eyelid fusion |
J:160781
|
|
increased incidence of corneal inflammation |
J:160781
|
|
lens vacuoles |
J:160781
|
|
microphthalmia |
J:160781
|
|
pathological neovascularization |
J:160781
|
|
pulmonary valve hypertrophy |
J:160781
|
|
thick aortic valve |
J:160781
|
|
thick pulmonary valve |
J:160781
|
|
waved hair |
J:156373,
J:160781
|
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