Adam17^tm1.1Rain
Targeted Allele Detail

Summary

• Symbol: Adam17^tm1.1Rain
• Name: a disintegrin and metallopeptidase domain 17; targeted mutation 1.1, Elaine W Raines
• MGI ID: MGI:5478748
• Synonyms: Adam17^Fl, Adam17^tm1uw
• Gene: Adam17 Location: Chr12:21373510-21423633 bp, - strand Genetic Position: Chr12, 8.3 cM
• Alliance: Adam17^tm1.1Rain page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195050
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 4 and an FRT flanked pgk-neo cassette and loxP site were inserted into intron 5 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 5 floxed. (J:195050)

Expression

In Mice Carrying this Mutation:	35 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam17 Mutation: 62 strains or lines available

References

• Original: J:195050 Wilson CL, et al., Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev. 2013 Apr-May;130(4-5):272-89
• All: 5 reference(s)