Adam17^tm1Bbl
Targeted Allele Detail

Summary

• Symbol: Adam17^tm1Bbl
• Name: a disintegrin and metallopeptidase domain 17; targeted mutation 1, Carl P Blobel
• MGI ID: MGI:3713365
• Synonyms: Tace^flox
• Gene: Adam17 Location: Chr12:21373510-21423633 bp, - strand Genetic Position: Chr12, 8.3 cM
• Alliance: Adam17^tm1Bbl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139846
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site, and a frt-flanked neomycin resistance cassette was inserted upstream of exon 2, and another loxP site and an EcoRI restriction site was inserted 1 kb downstream of exon 2. Correct targeting was confirmed by Southern blotting and genomic PCR. (J:139846)

Expression

In Mice Carrying this Mutation:	15 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam17 Mutation: 62 strains or lines available

References

• Original: J:139846 Horiuchi K, et al., Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J Immunol. 2007 Sep 1;179(5):2686-9
• All: 28 reference(s)