Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1Bbl mutation
(0 available);
any
Adam17 mutation
(62 available)
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normal phenotype
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• mice are viable and fertile and do not display any evident pathological phenotype or histopathological defects
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1Bbl mutation
(0 available);
any
Adam17 mutation
(62 available)
Lyz2tm1(cre)Ifo mutation
(14 available);
any
Lyz2 mutation
(41 available)
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homeostasis/metabolism
immune system
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• LPS stimulated release of TNF from macrophages is strongly reduced in these mice
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• TNF levels in the serum of mice expressing Cre are lower by more than two thirds compared to controls 3 hours after LPS injection
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• two weeks after induction of Cre recombinase, mice are more resistant to endotoxin shock than in controls
• 10 of 13 mice survive endotoxin induction with LPS and D-galactosamine while 11 of 13 controls die within 8 hours of injection
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hematopoietic system
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• LPS stimulated release of TNF from macrophages is strongly reduced in these mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1Bbl mutation
(0 available);
any
Adam17 mutation
(62 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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immune system
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• TNF levels in the serum of mice expressing Cre are lower by more than half compared to controls 3 hours after LPS injection
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• two weeks after induction of Cre recombinase, mice are more resistant to endotoxin shock than in controls
• 6 of 8 mice survive endotoxin induction with LPS and D-galactosamine while 7 of 8 controls die within 16 hours of injection
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homeostasis/metabolism
Analysis Tools
