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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Adam10
a disintegrin and metallopeptidase domain 10
MGI:109548
50 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Adam10tm1.1Dhc/Adam10tm1.1Dhc
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
abnormal B cell differentiation J:158127
absent marginal zone B cells J:158127
decreased transitional stage T2 B cell number J:158127
increased follicular B cell number J:158127
increased transitional stage T1 B cell number J:158127
Adam10tm1.1Khr/Adam10tm1.1Khr
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N
no abnormal phenotype detected J:179060
Adam10tm1.1Khr/Adam10tm1.1Khr
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N
abnormal bone marrow morphology J:179060
abnormal definitive hematopoiesis J:179060
abnormal granulocyte differentiation J:179060
abnormal spleen morphology J:179060
abnormal T cell differentiation J:179060
decreased CD4-positive, alpha beta T cell number J:179060
decreased CD8-positive, alpha-beta T cell number J:179060
decreased double-positive T cell number J:179060
decreased erythrocyte cell number J:179060
decreased hematocrit J:179060
decreased hemoglobin content J:179060
decreased T cell number J:179060
enlarged spleen J:179060
increased hematopoietic stem cell number J:179060
increased leukocyte cell number J:179060
increased neutrophil cell number J:179060
increased spleen red pulp amount J:179060
increased spleen weight J:179060
myeloid hyperplasia J:179060
small thymus J:179060
spleen hyperplasia J:179060
thymus hypoplasia J:179060
Adam10tm1.1Zhu/Adam10tm1.1Zhu
involves: 129S6/SvEvTac * C57BL/6 * SJL
embryonic lethality during organogenesis, complete penetrance J:139042
Adam10tm1Beni/Adam10tm1Beni
Tg(Pf4-icre)Q3Rsko/0
involves: 129/Sv * C57BL/6
abnormal platelet physiology J:165863
Adam10tm1Psa/Adam10tm1Psa
either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)
abnormal forebrain development J:94943
abnormal neural tube morphology J:94943
abnormal paraxial mesoderm morphology J:94943
abnormal pontine flexure morphology J:94943
abnormal somite development J:94943
abnormal umbilical cord morphology J:94943
abnormal visceral yolk sac morphology J:94943
abnormal vitelline vasculature morphology J:94943
absent intersomitic vessels J:94943
decreased embryo size J:94943
delayed heart development J:94943
distended pericardium J:94943
embryonic lethality during organogenesis, complete penetrance J:94943
failure of vascular branching J:94943
small first pharyngeal arch J:94943
Adam10tm1Zhu/Adam10tm1.1Zhu
Tg(Lck-cre)#Zhu/0
involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J
abnormal T cell differentiation J:139042
decreased CD4-positive, alpha beta T cell number J:139042
decreased double-positive T cell number J:139042
thymus hypoplasia J:139042
Adam10tm1Zhu/Adam10tm1Zhu
Tg(Lck-cre)#Zhu/0
involves: 129S6/SvEvTac * C57BL/6 * SJL/J
abnormal T cell differentiation J:139042
decreased CD4-positive, alpha beta T cell number J:139042
decreased double-positive T cell number J:139042
thymus hypoplasia J:139042
Adam10tm2Psa/Adam10tm2Psa
involves: 129P2/OlaHsd * C57BL/6J
no abnormal phenotype detected J:159624
Adam10tm2Psa/Adam10tm2Psa
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL
abnormal embryonic neuroepithelial layer differentiation J:159624
abnormal embryonic/fetal subventricular zone morphology J:159624
intracranial hemorrhage J:159624
perinatal lethality, incomplete penetrance J:159624
Adam10tm2Psa/Adam10tm2Psa
Tg(Serpinb7-icre)1Fech/0
involves: 129P2/OlaHsd * C57BL/6 * CBA
normal digestive/alimentary phenotype J:191899
forestomach hypoplasia J:191899

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory