Adam10^tm2Psa
Targeted Allele Detail

Summary

• Symbol: Adam10^tm2Psa
• Name: a disintegrin and metallopeptidase domain 10; targeted mutation 2, Paul Saftig
• MGI ID: MGI:4838238
• Synonyms: Adam10^Fl
• Gene: Adam10 Location: Chr9:70586279-70687511 bp, + strand Genetic Position: Chr9, 39.53 cM
• Alliance: Adam10^tm2Psa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159624
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The hygromycin B resistance gene, driven by the PGK (phosphoglycerate kinase) promoter flanked with two flippase recognition target sequences, one loxP sequence downstream of the hygromycin B resistance gene, was inserted in 5' upstream of exon2 in intron1. A second loxP sequence was inserted in intron 2. This is a conditional allele. (J:159624)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adam10 Mutation: 37 strains or lines available

References

• Original: J:159624 Jorissen E, et al., The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. J Neurosci. 2010 Apr 7;30(14):4833-44
• All: 25 reference(s)