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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kdm6a
lysine (K)-specific demethylase 6A
MGI:1095419
81 phenotypes from 13 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Kdm6aGt(RRA094)Byg/Y
chimera involves: 129P2/OlaHsd 		abnormal brain development J:160967
abnormal forebrain development J:160967
kinked neural tube J:160967
open neural tube J:160967
Kdm6aGt(RRA094)Byg/Y
either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1) 		decreased birth body size J:201868
decreased body size J:201868
exencephaly J:201868
perinatal lethality, incomplete penetrance J:201868
premature death J:201868
Kdm6aGt(RRA094)Byg/Kdm6aGt(RRA094)Byg
either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1) 		abnormal cardiovascular development J:201868
abnormal heart morphology J:201868
decreased embryo size J:201868
embryonic lethality during organogenesis, complete penetrance J:201868
failure of heart looping J:201868
myocardial trabeculae hypoplasia J:201868
open neural tube J:201868
pale yolk sac J:201868
pericardial edema J:201868
small heart J:201868
thin interventricular septum J:201868
thin ventricular wall J:201868
Kdm6atm1.1Afst/Y
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac 		normal hematopoietic system phenotype J:196401
Kdm6atm1.1Afst/Kdm6atm1.1Afst
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac 		abnormal bone marrow cell morphology/development J:196401
abnormal bone structure J:196401
abnormal erythropoiesis J:196401
abnormal granulocyte morphology J:196401
abnormal hematopoietic stem cell physiology J:196401
abnormal megakaryocyte morphology J:196401
anemia J:196401
decreased common myeloid progenitor cell number J:196401
decreased erythrocyte cell number J:196401
decreased erythroid progenitor cell number J:196401
decreased hemoglobin content J:196401
decreased leukocyte cell number J:196401
decreased mean corpuscular volume J:196401
enlarged spleen J:196401
extramedullary hematopoiesis J:196401
increased B cell number J:196401
increased spleen weight J:196401
spontaneous chromosome breakage J:196401
thrombocytopenia J:196401
weight loss J:196401
Kdm6atm1.1Kaig/Y
involves: 129S4/SvJaeSor 		no abnormal phenotype detected J:190157
Kdm6atm1.1Kaig/Kdm6atm1.1Kaig
involves: 129S4/SvJaeSor 		no abnormal phenotype detected J:190157
Kdm6atm1.1Kaig/Kdm6atm1.1Kaig
Pax7tm2.1(cre/ERT2)Fan/Pax7+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal muscle precursor cell morphology J:232700
impaired skeletal muscle regeneration J:232700
Kdm6atm1.1Kaig/Y
Pax7tm2.1(cre/ERT2)Fan/Pax7+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal muscle precursor cell morphology J:232700
impaired skeletal muscle regeneration J:232700
Kdm6atm1.2Afst/Y
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 		abnormal embryo development J:196401
abnormal heart development J:196401
cranioschisis J:196401
embryonic growth retardation J:196401
prenatal lethality, incomplete penetrance J:196401
Kdm6atm1.2Afst/Kdm6atm1.2Afst
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 		abnormal embryo development J:196401
abnormal heart development J:196401
cranioschisis J:196401
embryonic growth retardation J:196401
embryonic lethality during organogenesis, complete penetrance J:196401
Kdm6atm1.2Kaig/Y
involves: 129S4/SvJaeSor 		abnormal neural tube closure J:190157
atelectasis J:190157
normal embryo phenotype J:190157
exencephaly J:190157
perinatal lethality, complete penetrance J:190157
respiratory distress J:190157
Kdm6atm1.2Kaig/Kdm6atm1.2Kaig
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N 		abnormal heart development J:190157
abnormal neural tube closure J:190157
abnormal notochord morphology J:190157
abnormal rostral-caudal axis patterning J:190157
anemia J:190157
caudal body truncation J:190157
embryonic lethality during organogenesis, complete penetrance J:190157
Kdm6atm1a(EUCOMM)Jhha/Kdm6atm1b(EUCOMM)Jhha
Tg(Pgk1-cre)1Lni/0
involves: 129 * BALB/c * C57BL/6 * DBA 		embryonic lethality during organogenesis J:186686
open neural tube J:186686
Kdm6atm1a(EUCOMM)Jhha/Y
Tg(Pgk1-cre)1Lni/0
involves: 129 * BALB/c * C57BL/6 * DBA 		embryonic growth retardation J:186686
embryonic lethality during organogenesis, incomplete penetrance J:186686
Kdm6atm1b(EUCOMM)Jae/Y
involves: 129S4/SvJae * C57BL/6 * FVB/N 		decreased birth weight J:188485
embryonic lethality during organogenesis, incomplete penetrance J:188485
postnatal growth retardation J:188485
normal reproductive system phenotype J:188485
Kdm6atm1b(EUCOMM)Jae/Kdm6atm1b(EUCOMM)Jae
involves: 129S4/SvJae * C57BL/6 * FVB/N 		abnormal developmental patterning J:188485
abnormal heart development J:188485
abnormal neural tube closure J:188485
delayed somite formation J:188485
embryonic lethality during organogenesis, incomplete penetrance J:188485
failure of initiation of embryo turning J:188485
increased trophoblast giant cell number J:188485
Kdm6atm1b(EUCOMM)Wtsi/Y
either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1) 		decreased birth body size J:201868
decreased body size J:201868
exencephaly J:201868
perinatal lethality, incomplete penetrance J:201868
premature death J:201868
Kdm6atm1b(EUCOMM)Wtsi/Kdm6atm1b(EUCOMM)Wtsi
either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1) 		abnormal cardiovascular development J:201868
abnormal heart morphology J:201868
decreased embryo size J:201868
embryonic lethality during organogenesis, complete penetrance J:201868
failure of heart looping J:201868
myocardial trabeculae hypoplasia J:201868
open neural tube J:201868
pale yolk sac J:201868
pericardial edema J:201868
small heart J:201868
thin interventricular septum J:201868
thin ventricular wall J:201868
Kdm6atm1c(EUCOMM)Jae/Kdm6atm1c(EUCOMM)Jae
involves: 129S4/SvJae * C57BL/6 * DBA/2 		no abnormal phenotype detected J:188485
Kdm6atm1c(EUCOMM)Wtsi/Y
either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1) 		perinatal lethality, incomplete penetrance J:201868
Kdm6atm1c(EUCOMM)Wtsi/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
either: (involves: C57BL/6 * CBA * CD-1) or (involves: 129 * C57BL/6 * CBA * CD-1) 		normal mortality/aging J:201868
Kdm6atm1c(EUCOMM)Wtsi/Y
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6J * C57BL/6N * CBA 		abnormal cranial neural crest cell morphology J:294895
cleft hard palate J:294895
cleft palate J:294895
Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi
either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1) 		embryonic lethality during organogenesis, complete penetrance J:201868
open neural tube J:201868
Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi
Edil3Tg(Sox2-cre)1Amc/Edil3+
either: (involves: C57BL/6 * CBA * CD-1) or (involves: 129 * C57BL/6 * CBA * CD-1) 		lethality throughout fetal growth and development, complete penetrance J:201868
Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6J * C57BL/6N * CBA 		abnormal cranial neural crest cell morphology J:294895
cleft hard palate J:294895
cleft palate J:294895
Kdm6atm1Cdcn/Kdm6atm1Cdcn
Tg(CAG-cre/Esr1*)5Amc/0
involves: C57BL/6J * CBA 		abnormal hematopoietic stem cell physiology J:263565
decreased erythrocyte cell number J:263565
decreased erythroid progenitor cell number J:263565
decreased megakaryocyte-erythroid progenitor cell number J:263565
enlarged spleen J:263565
extramedullary hematopoiesis J:263565
increased chronic myelocytic leukemia incidence J:263565
increased granulocyte monocyte progenitor cell number J:263565
increased granulocyte number J:263565
increased hematopoietic stem cell number J:263565
increased monocyte cell number J:263565
increased myeloid cell number J:263565
increased neutrophil cell number J:263565
increased nucleated erythrocyte cell number J:263565
premature death J:263565
thrombocytopenia J:263565
Kdm6atm1Cdcn/Y
Tg(CAG-cre/Esr1*)5Amc/0
involves: C57BL/6J * CBA 		abnormal hematopoietic stem cell physiology J:263565
decreased erythrocyte cell number J:263565
decreased erythroid progenitor cell number J:263565
decreased megakaryocyte-erythroid progenitor cell number J:263565
enlarged spleen J:263565
extramedullary hematopoiesis J:263565
increased chronic myelocytic leukemia incidence J:263565
increased granulocyte monocyte progenitor cell number J:263565
increased granulocyte number J:263565
increased hematopoietic stem cell number J:263565
increased monocyte cell number J:263565
increased myeloid cell number J:263565
increased neutrophil cell number J:263565
increased nucleated erythrocyte cell number J:263565
premature death J:263565
thrombocytopenia J:263565
Kdm6atm2.1Kaig/Y
involves: 129 * C57BL/6 		abnormal muscle precursor cell morphology J:232700
impaired skeletal muscle regeneration J:232700
normal muscle phenotype J:232700
Kdm6atm2.1Kaig/Kdm6atm2.1Kaig
involves: 129 * C57BL/6 		abnormal muscle precursor cell morphology J:232700
impaired skeletal muscle regeneration J:232700
normal muscle phenotype J:232700
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory