145 phenotypes from 8 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdc42Gt(Ex160)Byg/Cdc42Gt(Ex160)Byg involves: 129P2/OlaHsd * C57BL/6	embryonic lethality between implantation and somite formation, complete penetrance	J:70273
Cdc42tm1.1Ayam/Cdc42tm1.1Ayam Tg(Mpz-cre)94Imeg/0 Not Specified	abnormal craniofacial bone morphology	J:250065
	abnormal frontal bone morphology	J:250065
	abnormal mandible morphology	J:250065
	abnormal medial nasal prominence morphology	J:250065
	abnormal nasal bone morphology	J:250065
	abnormal nasal septum morphology	J:250065
	abnormal premaxilla morphology	J:250065
	abnormal secondary palate development	J:250065
	absent gastric milk in neonates	J:250065
	absent palatal shelf	J:250065
	cleft palate	J:250065
	facial cleft	J:250065
	failure of palatal shelf elevation	J:250065
	intracranial hemorrhage	J:250065
	maxillary shelf hypoplasia	J:250065
	neonatal lethality, incomplete penetrance	J:250065
	palatine bone horizontal plate hypoplasia	J:250065
	short maxilla	J:250065
	short premaxilla	J:250065
	short snout	J:250065
Cdc42tm1.1Ayam/Cdc42tm1.1Ayam Tg(Prrx1-cre)1Cjt/0 involves: 129P2/OlaHsd * C57BL/6 * ICR * SJL	abnormal autopod joint morphology	J:184022
	abnormal autopod morphology	J:184022
	abnormal cartilage development	J:184022
	abnormal interdigital cell death	J:184022
	abnormal intramembranous bone ossification	J:184022
	abnormal joint morphology	J:184022
	abnormal limb bone morphology	J:184022
	abnormal limb morphology	J:184022
	abnormal long bone epiphyseal plate morphology	J:184022
	abnormal palatal shelf morphology	J:184022
	abnormal suckling behavior	J:184022
	abnormal xiphoid process morphology	J:184022
	brachydactyly	J:184022
	cleft palate	J:184022
	decreased birth body size	J:184022
	decreased body length	J:184022
	delayed fontanelle closure	J:184022
	disorganized long bone epiphyseal plate	J:184022
	fused metacarpal bones	J:184022
	fused phalanges	J:184022
	increased width of hypertrophic chondrocyte zone	J:184022
	interdigital webbing	J:184022
	neonatal lethality, incomplete penetrance	J:184022
	postnatal lethality, incomplete penetrance	J:184022
	short limbs	J:184022
	split sternum	J:184022
	syndactyly	J:184022
	weakness	J:184022
Cdc42tm1.1Rac/Cdc42tm1.1Rac involves: 129P2/OlaHsd * FVB/N	no abnormal phenotype detected	J:197886
Cdc42tm1.1Rac/Cdc42tm1.1Rac Tg(GFAP-cre)25Mes/0 involves: 129P2/OlaHsd * FVB/N	abnormal brain ependyma morphology	J:197886
	abnormal brain ventricle morphology	J:197886
	absent brain ependyma motile cilia	J:197886
	domed cranium	J:197886
	enlarged lateral ventricles	J:197886
	enlarged third ventricle	J:197886
	hydrocephaly	J:197886
	premature death	J:197886
	thin cerebral cortex	J:197886
Cdc42tm1.1Rac/Cdc42tm1.1Rac Tg(Nes-cre)1Kln/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	abnormal brain ependyma morphology	J:197886
	abnormal cell nucleus morphology	J:197886
	abnormal cerebral aqueduct morphology	J:197886
	abnormal cerebral cortex morphology	J:197886
	abnormal cortical plate morphology	J:197886
	abnormal cortical ventricular zone morphology	J:197886
	abnormal glial cell morphology	J:197886
	abnormal lateral ventricle morphology	J:197886
	abnormal neocortex morphology	J:197886
	abnormal neuronal precursor proliferation	J:197886
	abnormal spinal cord central canal morphology	J:197886
	abnormal third ventricle morphology	J:197886
	absent gastric milk in neonates	J:197886
	cerebral aqueductal stenosis	J:197886
	decreased locomotor activity	J:197886
	decreased neuronal precursor cell number	J:197886
	enlarged brain ventricles	J:197886
	intraventricular hemorrhage	J:197886
	postnatal lethality, complete penetrance	J:197886
	respiratory distress	J:197886
	small olfactory bulb	J:197886
	thin cerebral cortex	J:197886
Cdc42tm1.1Yizh/Cdc42+ Not Specified	decreased ventricle muscle contractility	J:174208
Cdc42tm1b(EUCOMM)Hmgu/Cdc42+ C57BL/6N-Cdc42tm1b(EUCOMM)Hmgu/H	abnormal cranium morphology	J:211773
	abnormal retina morphology	J:211773
	decreased circulating serum albumin level	J:211773
	enlarged kidney	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating aspartate transaminase level	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
Cdc42tm1b(EUCOMM)Hmgu/Cdc42tm1b(EUCOMM)Hmgu C57BL/6N-Cdc42tm1b(EUCOMM)Hmgu/H	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Cdc42tm1Brak/Cdc42tm1Brak Lgr5tm1(cre/ERT2)Cle/Lgr5+ involves: 129P2/OlaHsd * C57BL/6	abnormal crypts of Lieberkuhn morphology	J:184563
	absent Paneth cells	J:184563
Cdc42tm1Brak/Cdc42tm1Brak Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ involves: 129 * C57BL/6J	abnormal kidney cortex morphology	J:195266
	abnormal kidney development	J:195266
	abnormal kidney papilla morphology	J:195266
	abnormal nephrogenic zone morphology	J:195266
	abnormal proximal convoluted tubule morphology	J:195266
	anuria	J:195266
	decreased renal glomerulus number	J:195266
	decreased renal tubule number	J:195266
	postnatal lethality, complete penetrance	J:195266
	renal hypoplasia	J:195266
Cdc42tm1Brak/Cdc42tm1Brak Tg(KRT5-cre)5132Jlj/0 involves: C57BL/6J * DBA/2J	abnormal epidermal layer morphology	J:105811
	abnormal epidermis stratum corneum morphology	J:105811
	abnormal hair follicle matrix region morphology	J:105811
	abnormal hair follicle morphology	J:105811
	abnormal hair shaft morphology	J:105811
	abnormal keratinocyte morphology	J:105811
	absent hair follicle inner root sheath	J:105811
	dermal cyst	J:105811
	epidermal hyperplasia	J:105811
	hyperkeratosis	J:105811
	postnatal growth retardation	J:105811
Cdc42tm1Brak/Cdc42tm1Brak Tg(Pax8-rtTA2S*M2)1Koes/0 Tg(tetO-cre)LC1Bjd/0 involves: BALB/c * C57BL/6 * DBA	abnormal renal tubule epithelium morphology	J:221423
	increased susceptibility to kidney reperfusion injury	J:221423
Cdc42tm1Brak/Cdc42tm1Brak Tg(Pf4-icre)Q3Rsko/0 involves: 129 * C57BL/6	abnormal platelet activation	J:160792
	abnormal platelet dense granule physiology	J:160792
	abnormal platelet morphology	J:160792
	abnormal platelet physiology	J:160792
	increased bleeding time	J:160792
	increased platelet aggregation	J:160792
	increased susceptibility to induced thrombosis	J:160792
	thrombocytopenia	J:160792
Cdc42tm1Brak/Cdc42tm1Brak Tg(Plp1-cre/ERT2)1Ueli/0 involves: C57BL/6 * DBA/2	abnormal myelin sheath morphology	J:190437
Cdc42tm1Brak/Cdc42tm1Brak Tg(Vil1-cre)997Gum/0 involves: C57BL/6J * SJL	abnormal anus morphology	J:184563
	abnormal crypts of Lieberkuhn morphology	J:184563
	abnormal defecation	J:184563
	abnormal enterocyte morphology	J:184563
	abnormal intestinal enteroendocrine cell morphology	J:184563
	abnormal intestinal epithelium morphology	J:184563
	abnormal intestinal goblet cell morphology	J:184563
	abnormal intestine morphology	J:184563
	abnormal intestine physiology	J:184563
	abnormal small intestinal crypt cell physiology	J:184563
	decreased body size	J:184563
	decreased Paneth cell number	J:184563
	increased small intestinal crypt cell apoptosis	J:184563
	intestinal edema	J:184563
	postnatal growth retardation	J:184563
	premature death	J:184563
Cdc42tm1Fwa/Cdc42tm1Fwa involves: 129S6/SvEvTac	abnormal actin cytoskeleton morphology	J:63261
	absent embryonic epiblast	J:63261
	decreased embryo size	J:63261
	disorganized embryonic tissue	J:63261
	embryonic lethality between implantation and somite formation, complete penetrance	J:63261
Cdc42tm1Yizh/Cdc42tm1Yizh Foxg1tm1(cre)Skm/Foxg1+ involves: 129P2/OlaHsd	abnormal embryonic neuroepithelium morphology	J:116100
	abnormal eye development	J:116100
	abnormal folding of telencephalic vesicles	J:116100
	abnormal telencephalon development	J:116100
	holoprosencephaly	J:116100
	lethality throughout fetal growth and development, complete penetrance	J:116100
	small embryonic telencephalon	J:116100