Cdc42^tm1.1Rac
Targeted Allele Detail

Summary

• Symbol: Cdc42^tm1.1Rac
• Name: cell division cycle 42; targeted mutation 1.1, Richard A Cerione
• MGI ID: MGI:5495277
• Synonyms: Cdc42^flox
• Gene: Cdc42 Location: Chr4:137047007-137085031 bp, - strand Genetic Position: Chr4, 69.83 cM
• Alliance: Cdc42^tm1.1Rac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197886
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 2 was floxed. Cre-mediated recombination removed the floxed neo cassette. (J:197886)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdc42 Mutation: 43 strains or lines available

References

• Original: J:197886 Peng X, et al., Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice. Protein Cell. 2013 Mar;4(3):231-42
• All: 6 reference(s)