Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cdc42tm1.1Rac targeted mutation 1.1, Richard A Cerione MGI:5495277 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice die within 72 hours of birth
|
|
• more than half of mice exhibit mild or moderate hemorrhage in the lateral ventricle of the brain
|
|
• E18.5 glial cells exhibit a fried egg morphology in culture unlike wild-type cells
|
|
• at E14.5, only sporadic proliferating cells are located in the basal ventricular zone and subventricular zone compared with wild-type mice
• at E16.5, proliferating cells are displaced from the ventricular surface and are present randomly in the basal ventricular and subventricular zone compared with wild-type mice
|
|
• decreased cell number at E16.5
|
|
• decreased cell number at E16.5
• nuclei lose their apical-basal direction
|
|
• decreased cell number at E16.5
|
|
• clustering of the ependymal cells
• lack of lining ependymal cells inside the third ventricle, aqueduct and spinal cord central canal
|
|
• bilateral
|
|
• more than half of mice exhibit mild or moderate hemorrhage in the lateral ventricle of the brain
• neuronal cells lining the lateral ventricle lack apical membrane domain
|
|
• lack of lining ependymal cells
|
|
• lack of lining ependymal cells
|
|
• slight increase in cell numbers with disruption of cell polarization at E14.5
• flattened surface with hypoplasia
|
|
• abnormal orientation at E16.5 indicating a folding problem
|
|
• lacking ventricular and sub-ventricular zones
|
|
• slightly
|
|
• decreased apical neuronal progenitor cell numbers in the cerebral cortex at E14.5 and E16.5
|
|
• collapse of the central canal and lack of differentiated ependymal cells
|
|
• E18.5 glial cells exhibit a fried egg morphology in culture unlike wild-type cells
|
|
• at E14.5 and E16.5, radial glial cell nuclei exhibit impaired interkinetic nuclear migration compared to in wild-type cells
|
|
• at E14.5, only sporadic proliferating cells are located in the basal ventricular zone and subventricular zone compared with wild-type mice
• at E16.5, proliferating cells are displaced from the ventricular surface and are present randomly in the basal ventricular and subventricular zone compared with wild-type mice
|
|
• in neonates
|
|
• more than half of mice exhibit mild or moderate hemorrhage in the lateral ventricle of the brain
|
|
• in neonates
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• more than half of mice die before 3 months of age due to severe hydrocephalus
|
|
• severe
|
|
• ependymal cells are detached from the lateral and third ventricle
|
|
• ependymal cells are detached from the lateral and third ventricle
|
|
• in most mice at 4 weeks
|
|
• in most mice at 4 weeks
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/30/2025 MGI 6.24 |
|
|
|
||
