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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Yap1
yes-associated protein 1
MGI:103262
55 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Tg(Pbsn-cre)4Prb/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
increased prostate gland adenocarcinoma incidence J:222916
increased prostate gland tumor incidence J:222916
Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Tg(KRT14-cre)1Amc/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
abnormal epidermal layer morphology J:171057
abnormal epidermal stem cell morphology J:171057
abnormal hair growth J:171057
abnormal tongue epithelium morphology J:171057
hyperkeratosis J:171057
increased cell proliferation J:171057
increased skin squamous cell carcinoma incidence J:171057
thick epidermis J:171057
thick skin J:171057
wrinkled skin J:171057
Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
involves: 129S4/SvJae * C57BL/6
abnormal enterocyte proliferation J:141457
abnormal intestinal epithelium morphology J:141457
abnormal intestinal goblet cell morphology J:141457
absent Paneth cells J:141457
decreased alkaline phosphatase activity J:141457
enlarged pancreas J:141457
increased cell proliferation J:141457
increased pancreatic acinar cell number J:141457
pancreatic acinar-to-ductal metaplasia J:141457
premature death J:141457
thick skin J:141457
Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+
Tg(Cebpb-tTA)#Bjd/0
involves: 129S4/SvJae * C57BL/6
abnormal hepatocyte morphology J:141457
decreased hepatocyte apoptosis J:141457
enlarged liver J:141457
increased hepatocyte proliferation J:141457
increased liver weight J:141457
liver hyperplasia J:141457
Col1a1tm1(tetO-Yap1*)Lrsn/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
involves: 129S4/SvJae * C57BL/6
premature death J:185310
Krastm4Tyj/Krastm4Tyj
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
increased hepatocellular carcinoma incidence J:162628
Lats1tm1Noj/Lats1tm1Noj
Lats2tm1.1Dupa/Lats2tm1.1Dupa
Wwtr1tm1.2Eno/Wwtr1tm1.2Eno
Yap1tm1.1Dupa/Yap1tm1.1Dupa
involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas
abnormal bile duct epithelium morphology J:223215
enlarged liver J:223215
Mob1atm1.1Asuz/Mob1atm1.1Asuz
Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Yap1tm1c(KOMP)Mbp/Yap1tm1c(KOMP)Mbp
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA
abnormal cholangiocyte morphology J:228499
increased liver weight J:228499
liver fibrosis J:228499
Nf2tm2Gth/Nf2tm2Gth
Yap1tm1.1Dupa/Yap1+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA
enlarged liver J:162628
normal liver/biliary system phenotype J:162628
normal neoplasm J:162628
Nf2tm2Gth/Nf2tm2Gth
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA
normal liver/biliary system phenotype J:162628
normal neoplasm J:162628
Nf2tm2Gth/Nf2tm2Gth
Yap1tm2.1Dupa/Yap1tm2.1Dupa
involves: 129P2/OlaHsd
abnormal bile duct epithelium morphology J:223215
abnormal bile duct physiology J:223215
enlarged liver J:223215
increased hamartoma incidence J:223215
Sav1tm1.1Dupa/Sav1tm1.1Dupa
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Tg(Vil1-cre)997Gum/0
involves: 129P2/OlaHsd * C57BL/6J * SJL
normal digestive/alimentary phenotype J:165471
Tead1tm1Hssk/Tead1+
Tead2tm1Hssk/Tead2tm1Hssk
Yap1tm1Smil/Yap1+
either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)
abnormal developmental patterning J:131426
abnormal embryo turning J:131426
Tead1tm1Hssk/Tead1tm1Hssk
Tead2tm1Hssk/Tead2+
Yap1tm1Smil/Yap1+
either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)
abnormal allantois morphology J:131426
abnormal embryo development J:131426
abnormal embryonic tissue morphology J:131426
Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
Yap1tm1.1Fcam/Yap1+
Tg(Tek-cre)1Ywa/0
involves: 129S4/SvJae * C57BL/6N * CBA * SJL
normal cardiovascular system phenotype J:273437
Wwtr1tm1.1Eno/Wwtr1+
Yap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0
involves: 129S/SvEv * FVB/N
increased cardiomyocyte apoptosis J:200670
myocardium hypoplasia J:200670
postnatal lethality, complete penetrance J:200670
thin myocardium J:200670
Wwtr1tm1.1Eno/Wwtr1tm1.1Eno
Yap1tm1.1Eno/Yap1+
Tg(Myh6-cre)2182Mds/0
involves: 129S/SvEv * FVB/N
abnormal atrial thrombosis J:200670
dilated cardiomyopathy J:200670
premature death J:200670
Wwtr1tm1.1Eno/Wwtr1tm1.1Eno
Yap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0
involves: 129S/SvEv * FVB/N
abnormal heart morphology J:200670
neonatal lethality, complete penetrance J:200670
Wwtr1tm1Hku/Wwtr1tm1Hku
Yap1tm1Smil/Yap1tm1Smil
involves: 129S/SvEv
embryonic lethality before implantation, complete penetrance J:147050
Wwtr1tm1Hmc/Wwtr1tm1Hmc
Yap1tm1Hmc/Yap1tm1Hmc
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl
abnormal kidney development J:195266
decreased renal glomerulus number J:195266
decreased renal tubule number J:195266
kidney cysts J:195266

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory