31 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Col1a1tm1(tetO-Yap1*)Lrsn/Col1a1+ Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+ involves: 129S4/SvJae * C57BL/6	premature death	J:185310
Krastm4Tyj/Krastm4Tyj Yap1tm1.1Dupa/Yap1tm1.1Dupa Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA	increased hepatocellular carcinoma incidence	J:162628
Lats1tm1Noj/Lats1tm1Noj Lats2tm1.1Dupa/Lats2tm1.1Dupa Wwtr1tm1.2Eno/Wwtr1tm1.2Eno Yap1tm1.1Dupa/Yap1tm1.1Dupa involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas	abnormal bile duct epithelium morphology	J:223215
	enlarged liver	J:223215
Mob1atm1.1Asuz/Mob1atm1.1Asuz Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi Yap1tm1c(KOMP)Mbp/Yap1tm1c(KOMP)Mbp Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA	abnormal cholangiocyte morphology	J:228499
	increased liver weight	J:228499
	liver fibrosis	J:228499
Nf2tm2Gth/Nf2tm2Gth Yap1tm1.1Dupa/Yap1+ Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129P2/OlaHsd * C57BL/6 * DBA	enlarged liver	J:162628
	normal liver/biliary system phenotype	J:162628
	normal neoplasm	J:162628
Nf2tm2Gth/Nf2tm2Gth Yap1tm1.1Dupa/Yap1tm1.1Dupa Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129P2/OlaHsd * C57BL/6 * DBA	normal liver/biliary system phenotype	J:162628
	normal neoplasm	J:162628
Nf2tm2Gth/Nf2tm2Gth Yap1tm2.1Dupa/Yap1tm2.1Dupa involves: 129P2/OlaHsd	abnormal bile duct epithelium morphology	J:223215
	abnormal bile duct physiology	J:223215
	enlarged liver	J:223215
	increased hamartoma incidence	J:223215
Sav1tm1.1Dupa/Sav1tm1.1Dupa Yap1tm1.1Dupa/Yap1tm1.1Dupa Tg(Vil1-cre)997Gum/0 involves: 129P2/OlaHsd * C57BL/6J * SJL	normal digestive/alimentary phenotype	J:165471
Tead1tm1Hssk/Tead1+ Tead2tm1Hssk/Tead2tm1Hssk Yap1tm1Smil/Yap1+ either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)	abnormal developmental patterning	J:131426
	abnormal embryo turning	J:131426
Tead1tm1Hssk/Tead1tm1Hssk Tead2tm1Hssk/Tead2+ Yap1tm1Smil/Yap1+ either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)	abnormal allantois morphology	J:131426
	abnormal embryo development	J:131426
	abnormal embryonic tissue morphology	J:131426
Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu Yap1tm1.1Fcam/Yap1+ Tg(Tek-cre)1Ywa/0 involves: 129S4/SvJae * C57BL/6N * CBA * SJL	normal cardiovascular system phenotype	J:273437
Wwtr1tm1.1Eno/Wwtr1+ Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 involves: 129S/SvEv * FVB/N	increased cardiomyocyte apoptosis	J:200670
	myocardium hypoplasia	J:200670
	postnatal lethality, complete penetrance	J:200670
	thin myocardium	J:200670
Wwtr1tm1.1Eno/Wwtr1tm1.1Eno Yap1tm1.1Eno/Yap1+ Tg(Myh6-cre)2182Mds/0 involves: 129S/SvEv * FVB/N	abnormal atrial thrombosis	J:200670
	dilated cardiomyopathy	J:200670
	premature death	J:200670
Wwtr1tm1.1Eno/Wwtr1tm1.1Eno Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 involves: 129S/SvEv * FVB/N	abnormal heart morphology	J:200670
	neonatal lethality, complete penetrance	J:200670
Wwtr1tm1Hku/Wwtr1tm1Hku Yap1tm1Smil/Yap1tm1Smil involves: 129S/SvEv	embryonic lethality before implantation, complete penetrance	J:147050
Wwtr1tm1Hmc/Wwtr1tm1Hmc Yap1tm1Hmc/Yap1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl	abnormal kidney development	J:195266
	decreased renal glomerulus number	J:195266
	decreased renal tubule number	J:195266
	kidney cyst	J:195266