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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Vegfa
vascular endothelial growth factor A
MGI:103178
278 phenotypes from 15 alleles in 23 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+
Tg(Col2a1-cre)1Bhr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
abnormal bone marrow cavity morphology J:156474
abnormal bone ossification J:156474
abnormal bone structure J:156474
abnormal long bone diaphysis morphology J:156474
abnormal long bone morphology J:156474
abnormal rib morphology J:156474
decreased width of hypertrophic chondrocyte zone J:156474
perinatal lethality, complete penetrance J:156474
Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR
abnormal bone ossification J:156474
abnormal bone structure J:156474
Gt(ROSA)26Sortm6(Vegfa*)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
embryonic lethality J:194078
Tg(KRT14-Vegfa)3Dtm/0
FVB/N-Tg(KRT14-Vegfa)3Dtm
abnormal angiogenesis J:92643, J:104245, J:111924
abnormal capillary branching pattern J:104245
abnormal capillary morphology J:104245
abnormal epidermal layer morphology J:92643
abnormal leukocyte adhesion J:104245
abnormal lymphatic vessel morphology J:111924
delayed wound healing J:111924
enhanced leukocyte tethering or rolling J:104245
enlarged lymph nodes J:92643
enlarged lymphatic vessel J:92643
epidermal hyperplasia J:92643
increased capillary tortuosity J:104245
increased macrophage cell number J:111924
increased mast cell number J:104245
increased vascular permeability J:92643, J:104245
mixed cellular infiltration to dermis J:92643
parakeratosis J:92643
psoriasis J:92643
skin edema J:92643
Tg(Myh6-tTA)6Smbf/0
Tg(tetO-Vegfa)1Kesh/0
involves: C57BL/6 * CBA
abnormal cardiac epithelial to mesenchymal transition J:68214
abnormal cardiac outflow tract development J:68214
abnormal endocardium morphology J:68214
abnormal heart development J:68214
Tg(Neph1-Vegfa)1Seq/0
Not Specified
abnormal glomerular capillary endothelium morphology J:82440
abnormal glomerular capillary morphology J:82440
abnormal mesangial cell morphology J:82440
abnormal podocyte morphology J:82440
abnormal renal glomerulus morphology J:82440
albuminuria J:82440
cortical renal glomerulopathies J:82440
detached podocyte J:82440
dilated glomerular capillary J:82440
dilated proximal convoluted tubule J:82440
increased glomerular capsule space J:82440
kidney failure J:82440
kidney hemorrhage J:82440
postnatal growth retardation J:82440
postnatal lethality J:82440
renal cast J:82440
Vegfatm1.1Nagy/Vegfatm1.1Nagy
involves: 129S1/Sv * 129X1/SvJ
abnormal coronary vessel morphology J:64090
abnormal heart morphology J:64090
abnormal interventricular septum morphology J:64090
abnormal lymphatic vessel morphology J:64090
abnormal myocardial trabeculae morphology J:64090
abnormal truncus arteriosus septation J:64090
edema J:64090
enlarged heart J:64090
lethality throughout fetal growth and development, complete penetrance J:64090
thin ventricle myocardium compact layer J:64090
thin ventricular wall J:64090
Vegfatm1Dco/Vegfa+
involves: 129
abnormal dorsal aorta morphology J:32219
abnormal vitelline vasculature morphology J:32219
decreased angiogenesis J:32219
Vegfatm1Dco/Vegfatm1Dco
involves: 129
abnormal dorsal aorta morphology J:32219
abnormal vascular development J:32219
abnormal vascular endothelial cell differentiation J:32219
perinatal lethality, complete penetrance J:32219
Vegfatm1Gne/Vegfa+
involves: 129S2/SvPas * C57BL/6J
abnormal blood vessel morphology J:32218
abnormal dorsal aorta morphology J:32218
abnormal forebrain development J:32218
abnormal forelimb bud morphology J:32218
abnormal pharyngeal arch morphology J:32218
abnormal placenta vasculature J:32218
abnormal visceral yolk sac blood island morphology J:32218
abnormal vitelline vasculature morphology J:32218
abnormal vitelline vein morphology J:32218
delayed heart development J:32218
embryonic lethality during organogenesis, complete penetrance J:32218
increased embryonic neuroepithelium apoptosis J:32218
increased embryonic tissue cell apoptosis J:32218
thin ventricular wall J:32218
Vegfatm1Pec/Vegfatm1Pec
involves: 129S1/Sv * 129X1/SvJ
abnormal arteriole morphology J:75507
abnormal artery morphology J:75507, J:81698
abnormal blood vessel morphology J:56003, J:81698
abnormal capillary morphology J:56003, J:75507, J:81698
abnormal cardiac muscle relaxation J:56003
abnormal cardiovascular system physiology J:56003
abnormal carotid artery morphology J:81698
abnormal coronal suture morphology J:81698
abnormal coronary artery morphology J:56003, J:75507
abnormal coronary vessel morphology J:81698
abnormal facial motor nucleus morphology J:94050
abnormal fourth pharyngeal arch artery morphology J:81698
abnormal glomerular capillary endothelium morphology J:111504
abnormal glomerular capillary morphology J:111504
abnormal heart morphology J:56003, J:81698
abnormal impulse conducting system conduction J:56003
abnormal kidney afferent arteriole morphology J:111504
abnormal kidney arterial blood vessel morphology J:111504
abnormal kidney efferent arteriole morphology J:111504
abnormal kidney interlobular artery morphology J:111504
abnormal kidney vasculature morphology J:56003, J:75507
abnormal loop of Henle morphology J:111504
abnormal lung development J:77480
abnormal mandible morphology J:81698
abnormal mesangial cell morphology J:111504
abnormal myocardial fiber morphology J:56003
abnormal nephrogenic zone morphology J:111504
abnormal neuronal migration J:94050
abnormal pericyte morphology J:111504
abnormal peritubular capillary morphology J:111504
abnormal pharyngeal arch artery morphology J:81698
abnormal proximal convoluted tubule morphology J:111504
abnormal renal glomerulus basement membrane morphology J:111504
abnormal renal glomerulus basement membrane thickness J:111504
abnormal retina vasculature morphology J:56003, J:75507
abnormal sarcomere morphology J:56003
abnormal sixth pharyngeal arch artery morphology J:81698
abnormal ST segment J:56003
abnormal T wave J:56003
abnormal third pharyngeal arch artery morphology J:81698
abnormal thymus morphology J:81698
abnormal vascular regression J:81698
abnormal venule morphology J:75507
absent incisors J:81698
absent parathyroid glands J:81698
aorta pulmonary collateral arteries J:81698
atelectasis J:77480
athymia J:81698
cardiac ischemia J:56003
cervical aortic arch J:81698
cleft palate J:81698
cyanosis J:81698
decreased angiogenesis J:56003
decreased body weight J:56003
decreased capillary density J:56003
decreased cardiac muscle contractility J:56003
decreased glomerular capillary number J:111504
decreased heart rate J:56003
decreased left ventricle systolic pressure J:56003
decreased lymphocyte cell number J:81698
decreased neuron number J:175836
decreased renal glomerular filtration rate J:111504
decreased renal glomerulus number J:111504
dilated capillary J:56003, J:75507
dilated proximal convoluted tubule J:111504
double aortic arch J:81698
ectopic thymus J:81698
enlarged heart J:56003
expanded mesangial matrix J:111504
glomerulosclerosis J:111504
hemorrhage J:56003
increased blood urea nitrogen level J:111504
increased capillary tortuosity J:56003
increased circulating creatinine level J:111504
increased myocardial fiber size J:56003
increased neuron apoptosis J:175836
interrupted aortic arch, type b J:81698
irregular heartbeat J:56003
lethargy J:56003
myocardial fiber degeneration J:56003
neonatal lethality, incomplete penetrance J:56003, J:75507
overriding aortic valve J:81698
pale kidney J:111504
persistence of hyaloid vascular system J:75507
persistent ductus caroticus J:81698
persistent right dorsal aorta J:81698
persistent truncus arteriosus J:81698
postnatal lethality, complete penetrance J:56003
prolonged QRS complex duration J:56003
prolonged QT interval J:56003
pulmonary trunk hypoplasia J:81698
renal glomerulus hypertrophy J:111504
renal ischemia J:111504
respiratory distress J:77480
retina hemorrhage J:75507
retroesophageal right subclavian artery J:81698
right aortic arch J:81698
short mandible J:81698
small kidney J:111504
thick pulmonary interalveolar septum J:77480
thymus hypoplasia J:81698
ventricular septal defect J:81698
Vegfatm2.1Nagy/Vegfa+
involves: 129S1/Sv * 129X1/SvJ
abnormal brain vasculature morphology J:86207
abnormal vascular branching morphogenesis J:86207
Vegfatm2.1Nagy/Vegfatm2.1Nagy
involves: 129S1/Sv * 129X1/SvJ * CD-1
abnormal dorsal aorta morphology J:75937
abnormal vitelline vasculature morphology J:75937
decreased vascular endothelial cell number J:75937
delayed heart development J:75937
embryonic lethality between somite formation and embryo turning, complete penetrance J:75937
pancytopenia J:75937
Vegfatm2Gne/Vegfa+
Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
abnormal brain vasculature morphology J:86207
abnormal retina morphology J:86207
abnormal retina outer nuclear layer morphology J:86207
abnormal retina outer plexiform layer morphology J:86207
abnormal retina vasculature morphology J:86207
abnormal vascular branching morphogenesis J:86207
decreased angiogenesis J:86207
decreased brain size J:86207
decreased neuron number J:86207
retina degeneration J:86207
retina gliosis J:86207
Vegfatm2Gne/Vegfa+
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * C57BL/6
abnormal lung development J:124125
abnormal lung saccule morphology J:124125
abnormal pulmonary circulation J:124125
decreased pulmonary endothelial cell surface J:124125
pale lung J:124125
Vegfatm2Gne/Vegfa+
Tg(Nphs1-cre)1Seq/0
involves: 129
abnormal glomerular capillary endothelium morphology J:82440
abnormal glomerular capillary morphology J:82440
abnormal kidney morphology J:82440
abnormal podocyte morphology J:82440
absent glomerular endothelium fenestra J:82440
albuminuria J:82440
anemia J:82440
decreased skin turgor J:82440
dilated renal tubule J:82440
expanded mesangial matrix J:82440
glomerulosclerosis J:82440
increased blood urea nitrogen level J:82440
increased circulating creatinine level J:82440
increased renal glomerulus basement membrane thickness J:82440
increased urine protein level J:82440
kidney atrophy J:82440
kidney failure J:82440
lethargy J:82440
pale kidney J:82440
podocyte foot process effacement J:82440
renal cast J:82440
renal glomerulus atrophy J:82440
Vegfatm2Gne/Vegfatm2.1Nagy
Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
abnormal brain vasculature morphology J:86207
abnormal cerebral cortex morphology J:86207
abnormal choroid plexus morphology J:86207
abnormal craniofacial morphology J:86207
abnormal motor capabilities/coordination/movement J:86207
abnormal neuron physiology J:86207
abnormal neuron proliferation J:86207
abnormal retina vasculature morphology J:86207
abnormal vascular branching morphogenesis J:86207
absent gastric milk in neonates J:86207
decreased angiogenesis J:86207
dehydration J:86207
enlarged lateral ventricles J:86207
hydrocephaly J:86207
hypoxia J:86207
neonatal lethality, complete penetrance J:86207
neuron degeneration J:86207
Vegfatm2Gne/Vegfatm2Gne
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129/Sv * C3H * C57BL/6
abnormal intramembranous bone ossification J:309228
abnormal mandible morphology J:309228
abnormal maxilla morphology J:309228
abnormal palatal mesenchymal cell proliferation J:309228
abnormal palatal shelf bone ossification J:309228
abnormal palatal shelf elevation J:309228
abnormal secondary palate development J:309228
abnormal vascular development J:309228
decreased palatal shelf size J:309228
palatal shelf hypoplasia J:309228
palatal shelves fail to meet at midline J:309228
poor arterial differentiation J:309228
Vegfatm2Gne/Vegfatm2Gne
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129/Sv * 129P2/OlaHsd
decreased inflammatory response J:107682
Vegfatm2Gne/Vegfatm2Gne
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
normal immune system phenotype J:148597
normal mortality/aging J:148597
Vegfatm2Gne/Vegfatm2Gne
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129/Sv * 129P2/OlaHsd * FVB/N
abnormal wound healing J:189044
Vegfatm2Gne/Vegfatm2Gne
Lyz2tm1(cre)Ifo/Lyz2+
Tg(KRT14-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA * FVB/N
abnormal wound healing J:189044
Vegfatm2Gne/Vegfatm2Gne
Tg(Csf1r-cre/Esr1*)1Jwp/0
involves: 129 * C57BL/6 * FVB/N
decreased metastatic potential J:186831
Vegfatm2Gne/Vegfatm2Gne
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6 * CBA
abnormal liver development J:52793
decreased body size J:52793
extramedullary hematopoiesis J:52793
postnatal growth retardation J:52793
postnatal lethality, incomplete penetrance J:52793
Vegfatm2Gne/Vegfatm2Gne
Tg(Nphs1-cre)1Seq/0
involves: 129
abnormal glomerular capillary endothelium morphology J:82440
abnormal glomerular capillary morphology J:82440
abnormal glomerular filtration barrier morphology J:82440
abnormal mesangial cell morphology J:82440
abnormal podocyte morphology J:82440
abnormal podocyte slit diaphragm morphology J:82440
abnormal renal glomerulus morphology J:82440
absent glomerular endothelium fenestra J:82440
cortical renal glomerulopathies J:82440
edema J:82440
perinatal lethality, complete penetrance J:82440
podocyte foot process effacement J:82440
Vegfatm2Gne/Vegfatm2Gne
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129
abnormal retina vasculature morphology J:217533
Vegfatm2Gne/Vegfatm2Gne
Tg(Prrx1-cre)1Cjt/0
involves: 129/Sv * C57BL/6J * SJL/J
abnormal vascular branching morphogenesis J:147285
Vegfatm2Gne/Vegfatm2Gne
Tg(SFTPC-cre)#Mliu/0
involves: 129/Sv * ICR
abnormal induced morbidity/mortality J:158566
abnormal lung compliance J:158566
abnormal lung morphology J:158566
abnormal pulmonary circulation J:158566
abnormal respiratory system physiology J:158566
emphysema J:158566
lung inflammation J:158566
pulmonary edema J:158566
normal respiratory system phenotype J:158566
Vegfatm2Gne/Vegfatm2Gne
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * C57BL/6
abnormal lung development J:124125
abnormal lung epithelium morphology J:124125
abnormal lung saccule morphology J:124125
abnormal lung vasculature morphology J:124125
abnormal pulmonary acinus morphology J:124125
abnormal pulmonary circulation J:124125
decreased angiogenesis J:124125
decreased mesenchymal cell proliferation involved in lung development J:124125
decreased pulmonary endothelial cell surface J:124125
neonatal lethality, complete penetrance J:124125
pale lung J:124125
respiratory distress J:124125
Vegfatm2Gne/Vegfatm2Gne
Tg(Tnnt2-cre)5Blh/0
involves: 129/Sv * C57BL/6 * DBA
abnormal angiogenesis J:193198
abnormal coronary artery morphology J:193198
abnormal coronary vein morphology J:193198
abnormal coronary vessel morphology J:193198
abnormal heart septum morphology J:193198
normal cardiovascular system phenotype J:193198
decreased body size J:193198
heart hemorrhage J:193198
lethality throughout fetal growth and development, complete penetrance J:193198
myocardium necrosis J:193198
thin ventricular wall J:193198
Vegfatm2Pec/Vegfatm2Pec
involves: 129S1/Sv * 129X1/SvJ
abnormal axon morphology J:69797
abnormal blood circulation J:69797
abnormal capillary morphology J:69797
abnormal cranial nerve morphology J:69797
abnormal gait J:69797
abnormal grip strength J:69797
abnormal grooming behavior J:69797
abnormal lung development J:77480
abnormal motor capabilities/coordination/movement J:69797
abnormal muscle physiology J:69797
abnormal phrenic nerve morphology J:69797
abnormal sciatic nerve morphology J:69797
abnormal sexual interaction J:69797
abnormal somatic nervous system morphology J:69797
abnormal spinal cord ventral horn morphology J:69797
astrocytosis J:69797
atelectasis J:77480
axon degeneration J:69797
coarse hair J:69797
decreased body size J:69797
decreased locomotor activity J:69797
decreased survivor rate J:69797
female infertility J:69797
hindlimb paralysis J:84843
impaired coordination J:69797
impaired righting response J:69797
limb grasping J:69797
motor neuron degeneration J:69797
neurodegeneration J:69797
paresis J:69797
perinatal lethality, incomplete penetrance J:69797
progressive muscle weakness J:69797
scoliosis J:69797
skeletal muscle fiber atrophy J:69797
slow postnatal weight gain J:69797
thick pulmonary interalveolar septum J:77480
Vegfatm3.1Pec/Vegfatm3.1Pec
involves: 129S1/Sv * 129X1/SvJ
no abnormal phenotype detected J:75507, J:77480
Vegfatm3Gne/Vegfatm3Gne
involves: C57BL/6N
no abnormal phenotype detected J:126080
Vegfatm4Pec/Vegfatm4Pec
involves: 129S1/Sv * 129X1/SvJ
abnormal arteriole morphology J:75507
abnormal blood vessel morphology J:81698
abnormal fourth pharyngeal arch artery morphology J:81698
abnormal pharyngeal arch artery morphology J:81698
abnormal retina vasculature morphology J:75507
abnormal sixth pharyngeal arch artery morphology J:81698
abnormal third pharyngeal arch artery morphology J:81698
abnormal vascular regression J:81698
decreased body weight J:75507
decreased litter size J:75507
double aortic arch J:81698
embryonic lethality during organogenesis, incomplete penetrance J:75507, J:81698
interrupted aortic arch, type b J:81698
persistent right dorsal aorta J:81698
persistent truncus arteriosus J:81698
pharyngeal arch hypoplasia J:81698
pulmonary trunk hypoplasia J:81698
reduced fertility J:75507
normal respiratory system phenotype J:77480
retroesophageal right subclavian artery J:81698
right aortic arch J:81698
ventricular septal defect J:81698
Tg(NPHS2-rtTA2*M2)1Jbk/0
Tg(tetO-RNAi:Vegfa)#Atuf/0
involves: FVB
abnormal glomerular filtration barrier morphology J:189626
abnormal renal glomerulus basement membrane morphology J:189626
abnormal renal glomerulus morphology J:189626
decreased urine creatinine level J:189626
increased circulating creatinine level J:189626
increased urine protein level J:189626
kidney failure J:189626
mesangiolysis J:189626
podocyte foot process effacement J:189626

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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory