61 phenotypes from 7 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19tm1(cre)Cgn/Cd19+ Mcl1tm2Sjk/Mcl1tm3Sjk involves: 129P2/OlaHsd * 129X1/SvJ	abnormal B cell differentiation	J:86906
	absent early pro-B cells	J:86906
	absent late pro-B cells	J:86906
	absent pre-B cells	J:86906
	arrested B cell differentiation	J:86906
	decreased B cell number	J:86906
	increased B cell apoptosis	J:86906
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+ Mcl1tm1Ywh/Mcl1tm1Ywh involves: 129/Sv * 129S6/SvEvTac * C57BL/6	increased T cell apoptosis	J:137400
Mcl1em1(IMPC)Mbp/Mcl1+ C57BL/6N-Mcl1em1(IMPC)Mbp/MbpMmucd	abnormal eye morphology	J:211773
	abnormal heart morphology	J:211773
	abnormal lymph node morphology	J:211773
	anophthalmia	J:211773
	embryonic growth retardation	J:211773
	enlarged lymph nodes	J:211773
	increased grip strength	J:211773
	increased mean corpuscular volume	J:211773
	microphthalmia	J:211773
	small heart	J:211773
	small spleen	J:211773
Mcl1em1(IMPC)Mbp/Mcl1em1(IMPC)Mbp C57BL/6N-Mcl1em1(IMPC)Mbp/MbpMmucd	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773
Mcl1tm1Dmta/Mcl1+ Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte	decreased germinal center B cell number	J:166069
	decreased memory B cell number	J:166069
Mcl1tm1Dmta/Mcl1+ Tg(Aicda-cre)9Mbu/0 B6.Cg-Mcl1tm1Dmta Tg(Aicda-cre)9Mbu	decreased germinal center B cell number	J:166069
	decreased memory B cell number	J:166069
Mcl1tm1Dmta/Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte	abnormal B cell differentiation	J:166069
	absent germinal center B cells	J:166069
	absent memory B cells	J:166069
	decreased naive B cell number	J:166069
Mcl1tm1Dmta/Mcl1tm1Dmta Tg(Aicda-cre)9Mbu/0 B6.Cg-Mcl1tm1Dmta Tg(Aicda-cre)9Mbu	absent germinal center B cells	J:166069
	absent memory B cells	J:166069
	decreased IgG1 level	J:166069
	normal immune system phenotype	J:166069
Mcl1tm1Sjk/Mcl1tm1Sjk involves: 129X1/SvJ * C57BL/6	abnormal embryo attachment	J:59429
	normal embryo phenotype	J:59429
	embryonic growth arrest	J:59429
	embryonic lethality at implantation, complete penetrance	J:59429
	embryonic lethality before implantation, incomplete penetrance	J:59429
	failure of blastocyst to hatch from the zona pellucida	J:59429
Mcl1tm1Yen/Mcl1tm1Yen B6.129-Mcl1tm1Yen	abnormal CD8-positive, alpha-beta T cell physiology	J:146246
	abnormal double-positive T cell morphology	J:146246
	decreased CD8-positive, alpha-beta T cell number	J:146246
	decreased double-negative T cell number	J:146246
	decreased single-positive T cell number	J:146246
Mcl1tm1Ywh/Mcl1tm1Ywh Lyz2tm1(cre)Ifo/Lyz2+ involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	abnormal neutrophil physiology	J:137502
	decreased granulocyte number	J:137502
	decreased neutrophil cell number	J:137502
	normal immune system phenotype	J:137502
	impaired neutrophil recruitment	J:137502
	increased eosinophil cell number	J:137502
Mcl1tm1Ywh/Mcl1tm1Ywh Tg(Cd4-cre)1Cwi/0 involves: 129S6/SvEvTac * C57BL/6 * DBA/2	decreased CD4-positive, alpha-beta T cell number	J:137400
	decreased CD8-positive, alpha-beta T cell number	J:137400
	decreased T cell number	J:137400
	increased double-positive T cell number	J:137400
	increased T cell apoptosis	J:137400
Mcl1tm1Ywh/Mcl1tm1Ywh Tg(Lck-cre)548Jxm/0 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA	abnormal T cell differentiation	J:137400
	decreased CD4-positive, alpha-beta T cell number	J:137400
	decreased CD8-positive, alpha-beta T cell number	J:137400
	decreased double-negative T cell number	J:137400
	decreased double-positive T cell number	J:137400
	decreased T cell number	J:137400
	increased T cell apoptosis	J:137400
	thymus hypoplasia	J:137400
Mcl1tm2Sjk/Mcl1tm3Sjk Tg(Lck-cre)1Cwi/0 involves: 129X1/SvJ * C57BL/6 * DBA/2	arrested T cell differentiation	J:86906
	decreased double-negative T cell number	J:86906
	decreased double-positive T cell number	J:86906
	decreased T cell number	J:86906
	decreased thymocyte number	J:86906
	increased T cell apoptosis	J:86906
Mcl1tm2Sjk/Mcl1tm3Sjk Tg(Mx1-cre)1Cgn/0 involves: 129X1/SvJ * C57BL/6 * CBA	decreased B cell number	J:86906
	decreased T cell number	J:86906
Mcl1tm3Sjk/Mcl1tm3Sjk involves: 129X1/SvJ	no abnormal phenotype detected	J:86906
Mcl1tm3Sjk/Mcl1tm3Sjk Tg(Cpa3-cre)3Glli/0 involves: 129X1/Sv * C57BL/6	decreased basophil cell number	J:179080
	decreased erythrocyte cell number	J:179080
	decreased hematocrit	J:179080
	decreased inflammatory response	J:179080
	decreased mast cell number	J:179080
	decreased susceptibility to type I hypersensitivity reaction	J:179080
	normal hematopoietic system phenotype	J:179080
	macrocytic anemia	J:179080