About   Help   FAQ
Fgf8
Gene Detail
Symbol

Name
ID
Fgf8
fibroblast growth factor 8
MGI:99604
Synonyms
Aigf, Fgf-8
Feature Type
protein coding gene
Genetic Map
Chromosome 19
38.75 cM, cytoband C3-D
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr19:45736798-45742915 bp, - strand
From VEGA annotation of GRCm38

  6118 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7715  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FGF8
Gene Tree: Fgf8

Human
homologs
FGF8, fibroblast growth factor 8 (androgen-induced)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2253
neXtProt AC: NX_P55075

Human Synonyms: AIGF, FGF-8, HBGF-8, HH6, KAL6

Human Chr (Location): 10q24; chr10:101770130-101780369 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FGF8

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Targeted(19) Transgenic(1)
Genomic Mutations involving Fgf8 (3)
Incidental mutations (data from CvDC )
 
Homozygotes for targeted mutations exhibit cardiovascular defects (including abnormal left-right axis determination), impaired limb, thymic, and craniofacial development, and prenatal or early postnatal lethality.
 
Human Diseases Modeled in Mice Using Fgf8 (2)    Mutations Annotated to Human Diseases (3)   
Interactions
Fgf8 interacts with 24 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (895 records)
Data Summary: Results (1517)    Tissues (504)    Images (624)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
RNA in situ 1308
Northern blot 40
RT-PCR 134
RNase protection 24
cDNA source data(50)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FGF8 ; Xenbase fgf8 ; ZFIN fgf8a, fgf8b    NEW 
Molecular
reagents
All nucleic(151) Genomic(6) cDNA(61) Primer pair(21) Other(63)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021697 (Evidence)
Ensembl Gene Model ENSMUSG00000025219 (Evidence)
Entrez Gene 14179 (Evidence)
UniGene 4012
DFCI TC1591272, TC1593925, TC1594931
DoTS DT.101364484, DT.483287, DT.91332238, DT.91332240, DT.99853605
NIA Mouse Gene Index U039096
Consensus CDS Project CCDS29864.1, CCDS50450.1, CCDS50451.1, CCDS50452.1
International Mouse Phenotyping Consortium Status Fgf8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021697 VEGA Gene Model | MGI Sequence Detail 6118 C57BL/6J ±  kb
transcript OTTMUST00000051481 VEGA | MGI Sequence Detail 1168 Not Applicable 
polypeptide OTTMUSP00000024240 VEGA | MGI Sequence Detail 268 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(14) UniProt(6)
Polymorphisms
All PCR and RFLP(8) : PCR(1) RFLP(7) SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007499 fibroblast growth factor 8
References
(Earliest) J:2935 Tanaka A, et al., Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):8928-32
(Latest) J:223069 Chal J, et al., Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy. Nat Biotechnol. 2015 Aug 3;
All references(1011)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1237, MGD-MRK-16389

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory