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Fgf8
Gene Detail
 Symbol
Name
ID
Fgf8
fibroblast growth factor 8
MGI:99604
Synonyms Aigf, Fgf-8
Feature Type protein coding gene
Genetic Map
Chromosome 19
38.75 cM, cytoband C3-D
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr19:45736798-45742915 bp, - strand
From VEGA annotation of GRCm38

  6118 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7715  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Fgf8

Human
homologs
Human Homolog FGF8, fibroblast growth factor 8 (androgen-induced)
NCBI Gene ID 2253
neXtProt AC  NX_P55075
Human Synonyms  AIGF, FGF-8, HBGF-8, HH6, KAL6
Human Chr (Location)  10q24; chr10:101770130-101780369 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FGF8
Alleles
and
phenotypes
All alleles(15) : Targeted(15)
 
Homozygotes for targeted mutations exhibit cardiovascular defects (including abnormal left-right axis determination), impaired limb, thymic, and craniofacial development, and prenatal or early postnatal lethality.
 
Human Diseases Modeled Using Mouse Fgf8 (2)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (90 annotations)
Process aorta morphogenesis, apoptotic process, ...
Component external side of plasma membrane, extracellular region, ...
Function chemoattractant activity, fibroblast growth factor receptor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (831 records)
Data Summary: Results (1434)    Tissues (498)    Images (582)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 11
RNA in situ 1220
Northern blot 40
RT-PCR 139
RNase protection 24
cDNA source data(50)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(145) Genomic(6) cDNA(61) Primer pair(20) Other(58)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021697 (Evidence)
Ensembl Gene ModelENSMUSG00000025219 (Evidence)
Entrez Gene14179 (Evidence)
UniGene4012
DFCITC1591272, TC1593925, TC1594931
DoTSDT.101364484, DT.483287, DT.91332238, DT.91332240, DT.99853605
NIA Mouse Gene IndexU039096
Consensus CDS ProjectCCDS29864.1, CCDS50450.1, CCDS50451.1, CCDS50452.1
International Mouse Knockout Project StatusFgf8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021697 VEGA Gene Model | MGI Sequence Detail 6118 C57BL/6J ±  kb
transcript OTTMUST00000051481 VEGA | MGI Sequence Detail 1168 Not Applicable 
polypeptide OTTMUSP00000024240 VEGA | MGI Sequence Detail 268 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(16) UniProt(6)
Polymorphisms All PCR and RFLP(8) : PCR(1) RFLP(7) SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007499 fibroblast growth factor 8
References (Earliest) J:2935 Tanaka A, et al., Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):8928-32
(Latest) J:208254 Brooks LR, et al., Fibroblast growth factor deficiencies impact anxiety-like behavior and the serotonergic system. Behav Brain Res. 2014 May 1;264:74-81
All references(946)
Other
accession IDs
MGD-MRK-1237, MGD-MRK-16389

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory