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Fgf8 Gene Detail
Summary
  • Symbol
    Fgf8
  • Name
    fibroblast growth factor 8
  • Synonyms
    Aigf, Fgf-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:99604
    NCBI Gene: 14179
  • Gene Overview
    MyGene.info: FGF8
Location & Maps
more
  • Sequence Map
    Chr19:45736798-45742915 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6118 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 38.75 cM, cytoband C3-D
  • Mapping Data
    21 experiments
Homology
more
  • Human Ortholog
    FGF8, fibroblast growth factor 8
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FGF8, fibroblast growth factor 8
    Orthology source: HomoloGene
  • Synonyms
    AIGF, FGF-8, HBGF-8, HH6, KAL6
  • Links
    NCBI Gene ID: 2253
    neXtProt AC: NX_P55075

  • Chr Location
    10q24; chr10:101770130-101780369 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Fgf8 mouse models; 1 with human FGF8 associations

Human Disease Mouse Models
       DiGeorge Syndrome; DGS   OMIM: 188400 View 1 model
Tetralogy of Fallot; TOF   OMIM: 187500 View 1 model
       Hypogonadotropic Hypogonadism 6 with or without Anosmia; HH6   OMIM: 612702
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    159 phenotypes from 16 alleles in 20 genetic backgrounds
    76 phenotypes from multigenic genotypes
    124 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Targeted
    21
  • Transgenic
    2
  • Genomic Mutations
    3 involving Fgf8
  • Incidental Mutations
Homozygotes for targeted mutations exhibit cardiovascular defects (including abnormal left-right axis determination), impaired limb, thymic, and craniofacial development, and prenatal or early postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021697 VEGA Gene Model | MGI Sequence Detail 6118 C57BL/6J ±  kb
transcript OTTMUST00000051481 VEGA | MGI Sequence Detail 1168 Not Applicable  
polypeptide OTTMUSP00000024240 VEGA | MGI Sequence Detail 268 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    22 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 157
    Genomic 6
    cDNA 61
    Primer pair 22
    Other 68

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1237, MGD-MRK-16389
References
more
  • Summaries
    All 1040
    Developmental Gene Expression 924
    Diseases 3
    Gene Ontology 37
    Phenotypes 124
  • Earliest
    J:2935 Tanaka A, et al., Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):8928-32
  • Latest
    J:232111 Emechebe U, et al., T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory