Tg(Tbx1-cre)1Joe
Transgene Detail

Summary

• Symbol: Tg(Tbx1-cre)1Joe
• Name: transgene insertion 1, Jonathan A Epstein
• MGI ID: MGI:3037834
• Synonyms: Tbx1-Cre, Tbx1-enCre
• Transgene: Tg(Tbx1-cre)1Joe Location: unknown
• Alliance: Tg(Tbx1-cre)1Joe page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Tbx1-cre)1Joe expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tbx1 (MGI:98493)

• Mutation details: Sequence encoding cre recombinase was adjoined to mouse Tbx1 promoter sequence that extended 16 kb from the start codon and included the proximal promoter and three conserved enhancer regions. The expression pattern of cre recombinase recapitulated that of Tbx1, with expression observed in the mesenchyme, otic vesicle, and somites during development. (J:88814)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx1 (mouse) Summary of all recombinase alleles driven by Tbx1. Comparative matrix view of recombinase activities Alliance mouse Tbx1 gene page

Disease models

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:88814 Brown CB, et al., Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse. Dev Biol. 2004 Mar 1;267(1):190-202
• All: 4 reference(s)