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Chuk
Gene Detail
Symbol

Name
ID
Chuk
conserved helix-loop-helix ubiquitous kinase
MGI:99484
Synonyms
Chuk1, IkappaB kinase alpha, IKK1, IKK 1, IKK-1, IKK[a], IKKalpha, IKK alpha, IKK-alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 19
36.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr19:44073335-44107480 bp, - strand
From VEGA annotation of GRCm38

  34146 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:979  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: inhibitor of nuclear factor kappa-B kinase complex alpha-like subunit
Gene Tree: Chuk

Human
homologs
Human Homolog CHUK, conserved helix-loop-helix ubiquitous kinase
NCBI Gene ID 1147
neXtProt AC  NX_O15111
Human Synonyms  IKBKA, IKK1, IKKA, IKK-alpha, NFKBIKA, TCF16
Human Chr (Location)  10q24-q25; chr10:100188366-100229610 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CHUK
Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(19) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die neonataly and exhibit thickened, taut, adhesive skin that prevents appendages from protruding from the trunk, absence of whiskers, skeletal abnormalities, and closed esophagus.
 
Human Diseases Modeled Using Mouse Chuk (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Chuk interacts with 279 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process cellular response to tumor necrosis factor, I-kappaB phosphorylation, ...
Component CD40 receptor complex, cytoplasm, ...
Function ATP binding, IkappaB kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (82)    Tissues (64)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Northern blot 4
Western blot 8
RT-PCR 46
cDNA source data(104)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(109) cDNA(107) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000029724 (Evidence)
Ensembl Gene ModelENSMUSG00000025199 (Evidence)
Entrez Gene12675 (Evidence)
UniGene3996
DFCITC1575438, TC1585610
DoTSDT.101285624, DT.103560182, DT.533455, DT.94158624, DT.97346809
NIA Mouse Gene IndexU039070
EC2.7.11.10
Consensus CDS ProjectCCDS29843.1, CCDS50444.1
International Mouse Knockout Project StatusChuk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029724 VEGA Gene Model | MGI Sequence Detail 34146 C57BL/6J ±  kb
transcript OTTMUST00000073744 VEGA | MGI Sequence Detail 3502 Not Applicable 
polypeptide OTTMUSP00000038220 VEGA | MGI Sequence Detail 745 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(6) UniProt(9)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(203 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022007 I-kappa-kinase-beta NEMO binding domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000001775 inhibitor of nuclear factor kappa-B kinase subunit alpha
References
(Earliest) J:26193 Mock BA, et al., CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19. Genomics. 1995 May 20;27(2):348-51
(Latest) J:211784 Goktuna SI, et al., IKKalpha Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells. Cell Rep. 2014 Jun 26;7(6):1914-25
All references(167)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16258, MGI:2147493

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory