Chuk
Gene Detail

Symbol Name ID

Chuk conserved helix-loop-helix ubiquitous kinase MGI:99484

Synonyms

Chuk1, IkappaB kinase alpha, IKK1, IKK 1, IKK-1, IKK[a], IKKalpha, IKK alpha, IKK-alpha

Feature Type

protein coding gene

Genetic Map

Chromosome 19

36.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr19:44073335-44107480 bp, - strand From VEGA annotation of GRCm38   34146 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:979  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: inhibitor of nuclear factor kappa-B kinase complex alpha-like subunit
Gene Tree: Chuk

Human homologs

Human Homolog		CHUK, conserved helix-loop-helix ubiquitous kinase
NCBI Gene ID		1147
neXtProt AC		NX_O15111
Human Synonyms		IKBKA, IKK1, IKKA, IKK-alpha, NFKBIKA, TCF16
Human Chr (Location)		10q24-q25; chr10:101948124-101989344 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CHUK

Alleles and phenotypes

All alleles(30) : Targeted(11) Gene trapped(19)
 

Homozygotes for targeted null mutations die neonataly and exhibit thickened, taut, adhesive skin that prevents appendages from protruding from the trunk, absence of whiskers, skeletal abnormalities, and closed esophagus.

 
Human Diseases Modeled Using Mouse Chuk (1)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (50 annotations)

Process	I-kappaB phosphorylation, lactation, ...
Component	CD40 receptor complex, cytoplasm, ...
Function	ATP binding, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (82)    Tissues (64)    Images (4)
Theiler Stages: 10, 18, 23, 25, 26, 28

Assay Type	Results
RNA in situ	24
Northern blot	4
Western blot	8
RT-PCR	46

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) cDNA(23) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000029724 (Evidence)
Ensembl Gene Model	ENSMUSG00000025199 (Evidence)
Entrez Gene	12675 (Evidence)
DFCI	TC1575438, TC1585610
DoTS	DT.101285624, DT.103560182, DT.533455, DT.94158624, DT.97346809
NIA Mouse Gene Index	U039070
EC	2.7.11.10
Consensus CDS Project	CCDS29843.1, CCDS50444.1
International Mouse Knockout Project Status	Chuk

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029724	VEGA Gene Model | MGI Sequence Detail	34146	C57BL/6J
transcript	OTTMUST00000073744	VEGA | MGI Sequence Detail	3502	Not Applicable
polypeptide	OTTMUSP00000038220	VEGA | MGI Sequence Detail	745	Not Applicable

All sequences(62) RefSeq(4) UniProt(9)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(158 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022007	I-kappa-kinase-beta NEMO binding domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000001775	inhibitor of nuclear factor kappa-B kinase subunit alpha

References

(Earliest) J:26193 Mock BA, et al., CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19. Genomics. 1995 May 20;27(2):348-51
(Latest) J:195312 Mancino A, et al., I kappa B kinase alpha (IKKalpha) activity is required for functional maturation of dendritic cells and acquired immunity to infection. EMBO J. 2013 Mar 20;32(6):816-28
All references(145)

Other accession IDs

MGD-MRK-16258, MGI:2147493