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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Chuk
conserved helix-loop-helix ubiquitous kinase
MGI:99484
56 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Chuktm1Mka/Chuk+
SfnEr/SfnEr
involves: 129S1/Sv * 129X1/SvJ
normal craniofacial phenotype J:184926
Chuktm1Mka/Chuk+
Irf6tm1Mjd/Irf6tm1Mjd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal incisor morphology J:184926
Chuktm1Mka/Chuktm1Mka
Irf6tm1Mjd/Irf6+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal incisor morphology J:184926
Chuktm1Mpa/Chuktm1Mpa
Ikbkbtm2Cgn/Ikbkbtm2Cgn
Tg(Alb1-cre)7Gsc/0
involves: C57BL/6 * FVB/N
abnormal bile canaliculus morphology J:137861
abnormal bile duct morphology J:137861
cachexia J:137861
decreased survivor rate J:137861
increased circulating alanine transaminase level J:137861
increased circulating bilirubin level J:137861
increased susceptibility to endotoxin shock J:137861
intrahepatic cholestasis J:137861
jaundice J:137861
postnatal growth retardation J:137861
premature death J:137861
Chuktm1Ver/Chuktm1Ver
Ikbkbtm1Ver/Ikbkbtm1Ver
involves: 129S4/SvJae * C57BL/6J
abnormal cell physiology J:63443
abnormal dorsal root ganglion morphology J:63443
abnormal hindbrain morphology J:63443
abnormal neural fold elevation formation J:63443
embryonic lethality during organogenesis, complete penetrance J:63443
increased embryonic neuroepithelium apoptosis J:63443
increased hepatocyte apoptosis J:63443
increased hindbrain apoptosis J:63443
increased spinal cord apoptosis J:63443
liver degeneration J:63443
open neural tube J:63443
small embryonic telencephalon J:63443
Chuktm1Ver/Chuktm1Ver
Ikbkbtm1Ver/Ikbkbtm1Ver
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129/Sv * 129S4/SvJae * C57BL/6J
broad limb buds J:63443
curly tail J:63443
lethality throughout fetal growth and development, complete penetrance J:63443
open neural tube J:63443
Chuktm1Ver/Chuktm1Ver
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129/Sv * 129S4/SvJae * C57BL/6J
broad limb buds J:63443
curly tail J:63443
Chuktm1Yhu/Chuktm1Yhu
Egfrtm1Mag/Egfr+
Tg(KRT5-cre)5132Jlj/0
involves: 129 * C57BL/6 * CD-1
abnormal coat/ hair morphology J:141162
abnormal eye morphology J:141162
decreased survivor rate J:141162
premature death J:141162
thick epidermis J:141162
Chuktm1Yhu/Chuktm1Yhu
Egfrtm1Mag/Egfrtm1Mag
Tg(KRT5-cre)5132Jlj/0
involves: 129 * C57BL/6 * CD-1
postnatal lethality, complete penetrance J:141162
Chuktm1Yhu/Chuktm1Yhu
Egfrwa2/Egfrwa2
Tg(KRT5-cre)5132Jlj/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal epidermal layer morphology J:141162
normal integument phenotype J:141162
premature death J:141162
Chuktm1Yhu/Chuktm1Yhu
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT5-cre)5132Jlj/0
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
epidermal hyperplasia J:141162
postnatal lethality J:141162
thick epidermis J:141162
Chuktm2Mka/Chuktm2Mka
Tg(MMTV-CCND1)1Esmp/?
Not Specified
normal endocrine/exocrine gland phenotype J:90978
Chuktm2Mka/Chuktm2Mka
Tg(Tnfsf13b)1Fma/?
B6.Cg-Chuktm2Mka Tg(Tnfsf13b)1Fma
abnormal B cell activation J:113556
absent spleen marginal zone J:113556
decreased marginal zone B cell number J:113556
increased anti-double stranded DNA antibody level J:113556
increased transitional stage B cell number J:113556
increased urine protein level J:113556
Chuktm2Yhu/Chuktm2Yhu
Tg(KRT5-CHUK)#Yhu/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N
normal mortality/aging J:197037
normal neoplasm J:197037
Chuktm2Yhu/Chuktm2Yhu
Tg(Lor-CHUK)8Yhu/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
increased CD4-positive, alpha-beta T cell number J:197037
increased CD8-positive, alpha-beta T cell number J:197037
increased macrophage cell number J:197037
increased neutrophil cell number J:197037
increased squamous cell carcinoma incidence J:197037
lung inflammation J:197037
stomach mucosa hyperplasia J:197037
Chuktm2Yhu/Chuktm2Yhu
Tg(Lor-CHUK)8Yhu/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N
absent lymph nodes J:197037
enlarged lung J:197037
increased lung squamous cell carcinoma incidence J:197037
increased lung tumor incidence J:197037
normal integument phenotype J:197037
premature death J:197037

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory