About   Help   FAQ
Radiation induced Allele Detail
Symbol: SfnEr
Name: stratifin; repeated epilation
MGI ID: MGI:1861121
Synonyms: Er
Gene: Sfn  Location: Chr4:133327867-133329163 bp, - strand  Genetic Position: Chr4, 66.25 cM, cytoband D3
Alliance: SfnEr page
Abnormal skin morphology of SfnEr/Sfn+ and SfnEr/SfnEr mice

Show the 12 phenotype image(s) involving this allele.

Strain of Origin:  Not Specified
Allele Type:    Radiation induced
Mutation:    Insertion
Mutation detailsA single T insertion between base pairs 623 and 624 (cDNA from transcript ENSMUST00000057311.4) causes a frameshift mutation at amino acid residue 207 truncating the C-terminus of the protein (ADLHTLSEDSY TO ADLHTLQ[STOP]). This eliminates residues required for ligand interaction. Production of truncated protein was demonstrated immunologically. The hair-loss phenotype could be rescued using a Sfn containing transgene. (J:101891)
Inheritance:    Semidominant
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 35 assay results
In Structures Affected by this Mutation: 48 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying SfnEr
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sfn Mutation:  12 strains or lines available
Sfn is on Chr 4 close to pupoid fetus (pf), a mutant which SfnEr closely resembles.
Original:  J:29020 Hunsicker, Repeated epilation, Er. Mouse News Lett. 1960;23:58-9
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory