Tg(KRT5-CHUK)#Yhu
Transgene Detail

Summary

• Symbol: Tg(KRT5-CHUK)#Yhu
• Name: transgene insertion, Yinling Hu
• MGI ID: MGI:5515804
• Synonyms: K5.IKKalpha
• Transgene: Tg(KRT5-CHUK)#Yhu Location: unknown
• Alliance: Tg(KRT5-CHUK)#Yhu page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT5-CHUK)#Yhu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CHUK (1147)

  Chuk	(MGI:99484)

• Tg(KRT5-CHUK)#Yhu expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: The bovine promoter drives expression of the human cDNA with an HA tag in the basal epidermal keratinocytes and basal lung epithelial cells of bronchia. Lines 7 and 4 were generated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:201800)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:201800 Liu B, et al., IKKalpha represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin. Cell Death Differ. 2011 Dec;18(12):1854-64
• All: 3 reference(s)