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Sox2
Gene Detail
 Symbol
Name
ID
Sox2
SRY (sex determining region Y)-box 2
MGI:98364
Synonyms lcc, Sox-2, ysb
Feature Type protein coding gene
Genetic Map
Chromosome 3
16.93 cM, cytoband A2-B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:34650405-34652461 bp, + strand
From VEGA annotation of GRCm38

  2057 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68298  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sox2

Human
homologs
Human Homolog SOX2, SRY (sex determining region Y)-box 2
NCBI Gene ID 6657
neXtProt AC  NX_P48431
Human Synonyms  ANOP3, MCOPS3
Human Chr (Location)  3q26.3-q27; chr3:181711924-181714436 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SOX2
Alleles
and
phenotypes
All alleles(22) : Radiation induced(1) Targeted(20) Transgenic(1)
Incidental mutations (data from Mutagenetix )
 
Homozygotes for targeted null mutations implant but fail to develop an egg cylinder or epiblast, and die shortly thereafter. Other mutations that affect only regulatory elements show circling behavior and deafness, inner ear defects, and a yellow coat color.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (99 annotations)
Process adenohypophysis development, anatomical structure formation involved in morphogenesis, ...
Component cytoplasm, cytosol, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (483 records)
Data Summary: Results (1050)    Tissues (490)    Images (307)
Theiler Stages: 1, 2, 3, 4, 5, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 183
RNA in situ 667
In situ reporter (knock in) 43
Northern blot 2
RT-PCR 150
RNase protection 5
cDNA source data(35)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(62) cDNA(40) Primer pair(17) Other(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021249 (Evidence)
Ensembl Gene ModelENSMUSG00000074637 (Evidence)
Entrez Gene20674 (Evidence)
UniGene65396
DFCITC1580031, TC1589568
DoTSDT.485645, DT.91351945, DT.99854006
NIA Mouse Gene IndexU003145
PDB1GT0
Consensus CDS ProjectCCDS38413.1
International Mouse Knockout Project StatusSox2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021249 VEGA Gene Model | MGI Sequence Detail 2057 C57BL/6J ±  kb
transcript OTTMUST00000050334 VEGA | MGI Sequence Detail 2057 Not Applicable 
polypeptide OTTMUSP00000023485 VEGA | MGI Sequence Detail 319 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR022097 Transcription factor SOX
Protein Ontology PR:000015426 transcription factor SOX-2
References (Earliest) J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
(Latest) J:210599 Xu C, et al., Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression. Cancer Cell. 2014 May 12;25(5):590-604
All references(585)
Other
accession IDs
MGD-MRK-14493, MGD-MRK-14503, MGI:1891165, MGI:2181707

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory