Sox2
Gene Detail

Symbol Name ID

Sox2 SRY-box containing gene 2 MGI:98364

Synonyms

lcc, Sox-2, ysb

Feature Type

protein coding gene

Genetic Map

Chromosome 3

16.93 cM, cytoband A2-B
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr3:34650405-34652461 bp, + strand From VEGA annotation of GRCm38   2057 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68298  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sox2

Human homologs

Human Homolog		SOX2, SRY (sex determining region Y)-box 2
NCBI Gene ID		6657
neXtProt AC		NX_P48431
Human Synonyms		ANOP3, MCOPS3
Human Chr (Location)		3q26.3-q27; chr3:181429712-181432224 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SOX2

Alleles and phenotypes

All alleles(21) : Targeted(19) Transgenic(1) Radiation induced(1)
 

Homozygotes for targeted null mutations implant but fail to develop an egg cylinder or epiblast, and die shortly thereafter. Other mutations that affect only regulatory elements show circling behavior and deafness, inner ear defects, and a yellow coat color.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (92 annotations)

Process	adenohypophysis development, anatomical structure formation involved in morphogenesis, ...
Component	cytoplasm, cytosol, ...
Function	chromatin binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (387 records)
Data Summary: Results (993)    Tissues (467)    Images (282)
Theiler Stages: 1, 2, 3, 4, 5, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	164
RNA in situ	629
In situ reporter (knock in)	43
Northern blot	2
RT-PCR	150
RNase protection	5

cDNA source data(35)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(60) cDNA(39) Primer pair(17) Other(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021249 (Evidence)
Ensembl Gene Model	ENSMUSG00000074637 (Evidence)
Entrez Gene	20674 (Evidence)
UniGene	65396
DFCI	TC1580031, TC1589568
DoTS	DT.485645, DT.91351945, DT.99854006
NIA Mouse Gene Index	U003145
PDB	1GT0
Consensus CDS Project	CCDS38413.1
International Mouse Knockout Project Status	Sox2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021249	VEGA Gene Model | MGI Sequence Detail	2057	C57BL/6J
transcript	OTTMUST00000050334	VEGA | MGI Sequence Detail	2057	Not Applicable
polypeptide	OTTMUSP00000023485	VEGA | MGI Sequence Detail	319	Not Applicable

All sequences(30) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009071	High mobility group (HMG) box domain
InterPro	IPR022097	Transcription factor SOX
Protein Ontology	PR:000015426	transcription factor SOX-2

References

(Earliest) J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
(Latest) J:195190 Liu K, et al., Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells. Cell Stem Cell. 2013 Mar 7;12(3):304-15
All references(474)

Other accession IDs

MGD-MRK-14493, MGD-MRK-14503, MGI:1891165, MGI:2181707