Rb1
Gene Detail

Symbol Name ID

Rb1 retinoblastoma 1 MGI:97874

Synonyms

pRb, Rb, Rb-1

Feature Type

protein coding gene

Genetic Map

Chromosome 14

38.73 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(32)

Sequence Map

Chr14:73183673-73325822 bp, - strand From VEGA annotation of GRCm38   142150 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:272  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cyclin-fold protein, RB type
Gene Tree: Rb1

Human homologs

Human Homolog		RB1, retinoblastoma 1
NCBI Gene ID		5925
neXtProt AC		NX_P06400
Human Synonyms		OSRC, p105-Rb, pp110, pRb, RB
Human Chr (Location)		13q14.2; chr13:48877883-49056026 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human RB1

Alleles and phenotypes

All alleles(47) : Targeted(23) Gene trapped(24)
 

Homozygotes for targeted mutations exhibit abnormalities of the neuronal and hematopoietic systems and die in utero. Heterozygotes may develop pituitary tumors associated with loss of the normal allele.

 
Human Diseases Modeled Using Mouse Rb1 (5)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (74 annotations)

Process	cell cycle, cell cycle arrest, ...
Component	nucleus, PML body, ...
Function	core promoter binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (68 records)
Data Summary: Results (192)    Tissues (62)    Images (26)
Theiler Stages: 1, 2, 3, 4, 5, 6, 7, 9, 11, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	37
Northern blot	53
Western blot	86
RT-PCR	16

cDNA source data(81)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(92) Genomic(5) cDNA(84) Primer pair(2) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000036132 (Evidence)
Ensembl Gene Model	ENSMUSG00000022105 (Evidence)
Entrez Gene	19645 (Evidence)
UniGene	273862
DFCI	TC1577332, TC1675173
DoTS	DT.60100633, DT.60118750, DT.94254317
NIA Mouse Gene Index	U085478
Consensus CDS Project	CCDS27267.1
International Mouse Knockout Project Status	Rb1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036132	VEGA Gene Model | MGI Sequence Detail	142150	C57BL/6J
transcript	OTTMUST00000092874	VEGA | MGI Sequence Detail	4656	Not Applicable
polypeptide	OTTMUSP00000051423	VEGA | MGI Sequence Detail	921	Not Applicable

All sequences(47) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(6) : SNPs(854 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013763	Cyclin-like
InterPro	IPR024599	Domain of unknown function DUF3452, retinoblastoma-associated
InterPro	IPR015030	Rb C-terminal
InterPro	IPR015652	Retinoblastoma-associated protein
InterPro	IPR002720	Retinoblastoma-associated protein, A-box
InterPro	IPR002719	Retinoblastoma-associated protein, B-box
Protein Ontology	PR:000013773	retinoblastoma-associated protein

References

(Earliest) J:22884 Friend SH, et al., A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature. 1986 Oct 16-22;323(6089):643-6
(Latest) J:195318 Lu Z, et al., pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location. EMBO J. 2013 Mar 20;32(6):844-57
All references(499)

Other accession IDs

MGD-MRK-13784, MGD-MRK-13785