Phenotypes Associated with This Genotype

Genotype
MGI:5789748

• Allelic Composition: Rb1^tm2Brn/Rb1^tm2Brn; Rbl1^tm1Tyj/Rbl1^tm1Tyj; Rbl2^tm2Tyj/Rbl2^tm2Tyj
• Genetic Background: involves: 129 * 129S2/SvPas * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased urinary bladder carcinoma incidence ( J:217195 )

• mice injected with an adenovirus expressing cre-recombinase (AdCre) into the bladder lumen all develop bladder lesions that resemble high-grade non-muscle-invasive carcinoma

• bladder tumors display high proliferation and invade the basal lamina

• metastases are not seen for up to 1 year after AdCre infection

renal/urinary system

hematuria ( J:217195 )

• hematuria is sometimes seen in mice injected with AdCre into the bladder lumen with bladder lesions

increased urinary bladder carcinoma incidence ( J:217195 )

• mice injected with an adenovirus expressing cre-recombinase (AdCre) into the bladder lumen all develop bladder lesions that resemble high-grade non-muscle-invasive carcinoma

• bladder tumors display high proliferation and invade the basal lamina

• metastases are not seen for up to 1 year after AdCre infection

homeostasis/metabolism

hematuria ( J:217195 )

• hematuria is sometimes seen in mice injected with AdCre into the bladder lumen with bladder lesions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
urinary bladder cancer		DOID:11054	OMIM:109800	J:217195