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Rac1
Gene Detail
Symbol

Name
ID
Rac1
RAS-related C3 botulinum substrate 1
MGI:97845
Synonyms
D5Ertd559e
Feature Type
protein coding gene
Genetic Map
Chromosome 5
82.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:143505478-143528036 bp, - strand
From VEGA annotation of GRCm38

  22559 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69035  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RAC1
Protein SuperFamily: small GTPase, Rho type
Gene Tree: Rac1

Human
homologs
RAC1, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5879
neXtProt AC: NX_P63000

Human Synonyms: MIG5, p21-Rac1, Rac-1, TC-25

Human Chr (Location): 7p22; chr7:6374495-6403967 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(48) : Gene trapped(37) Targeted(10) Transgenic(1)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit embryonic lethality prior to embryonic day 9.5 with defects in gastrulation. Neutrophil specific knockout mice show defects in inflammatory recruitment and chemotactic responses.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Rac1 interacts with 234 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (111 annotations)
Process actin cytoskeleton organization, actin filament organization, ...
Component actin filament, cell projection, ...
Function enzyme binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (52 records)
Data Summary: Results (178)    Tissues (145)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 22
RNA in situ 137
Western blot 13
RT-PCR 6
cDNA source data(23)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA RAC1 ; Xenbase rac1 ; ZFIN rac1a    NEW 
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(23) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000020705 (Evidence)
Ensembl Gene Model ENSMUSG00000001847 (Evidence)
Entrez Gene 19353 (Evidence)
Consensus CDS Project CCDS19843.1
International Mouse Phenotyping Consortium Status Rac1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020705 VEGA Gene Model | MGI Sequence Detail 22559 C57BL/6J ±  kb
transcript OTTMUST00000049001 VEGA | MGI Sequence Detail 2325 Not Applicable 
polypeptide OTTMUSP00000022621 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(140 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003578 Small GTPase superfamily, Rho type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013660 ras-related C3 botulinum toxin substrate 1
References
(Earliest) J:724 Moll J, et al., The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments. Oncogene. 1991 May;6(5):863-6
(Latest) J:220364 Abu-Issa R, Rac1 modulates cardiomyocyte adhesion during mouse embryonic development. Biochem Biophys Res Commun. 2015 Jan 24;456(4):847-52
All references(297)
Other
accession IDs
MGD-MRK-13748, MGI:1261850, MGI:2141016

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory