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Rac1 Gene Detail
Summary
  • Symbol
    Rac1
  • Name
    RAS-related C3 botulinum substrate 1
  • Synonyms
    D5Ertd559e
  • Feature Type
    protein coding gene
  • IDs
    MGI:97845
    NCBI Gene: 19353
  • Gene Overview
    MyGene.info: RAC1
Location & Maps
more
  • Sequence Map
    Chr5:143503634-143528036 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24403 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 82.22 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    RAC1, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAC1, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MIG5, p21-Rac1, Rac-1, TC-25
  • Links
    NCBI Gene ID: 5879
    neXtProt AC: NX_P63000

  • Chr Location
    7p22; chr7:6374495-6403967 (+)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    78 phenotypes from 9 alleles in 13 genetic backgrounds
    23 phenotypes from multigenic genotypes
    138 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    49
  • Gene trapped
    37
  • Targeted
    10
  • Transgenic
    2
  • Incidental Mutations
    APF
Homozygotes for targeted null mutations exhibit embryonic lethality prior to embryonic day 9.5 with defects in gastrulation. Neutrophil specific knockout mice show defects in inflammatory recruitment and chemotactic responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020705 VEGA Gene Model | MGI Sequence Detail 24403 C57BL/6J ±  kb
transcript OTTMUST00000049001 VEGA | MGI Sequence Detail 2325 Not Applicable  
polypeptide OTTMUSP00000022621 VEGA | MGI Sequence Detail 211 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    156 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000013660 ras-related C3 botulinum toxin substrate 1
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 26
    Genomic 1
    cDNA 23
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-13748, MGI:1261850, MGI:2141016
References
more
  • Summaries
    All 311
    Developmental Gene Expression 55
    Diseases 1
    Gene Ontology 49
    Phenotypes 138
  • Earliest
    J:724 Moll J, et al., The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments. Oncogene. 1991 May;6(5):863-6
  • Latest
    J:227691 Cheung EC, et al., Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Genes Dev. 2016 Jan 1;30(1):52-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory