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Rac1
Gene Detail
 Symbol
Name
ID
Rac1
RAS-related C3 botulinum substrate 1
MGI:97845
Synonyms D5Ertd559e
Feature Type protein coding gene
Genetic Map
Chromosome 5
82.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:143505478-143528036 bp, - strand
From VEGA annotation of GRCm38

  22559 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69035  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: small GTPase, Rho type
Gene Tree: Rac1

Human
homologs
Human Homolog RAC1, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
NCBI Gene ID 5879
neXtProt AC  NX_P63000
Human Synonyms  p21-Rac1, Rac-1, TC-25
Human Chr (Location)  7p22; chr7:6374495-6403967 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Gene trapped(37) Targeted(7)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit embryonic lethality prior to embryonic day 9.5 with defects in gastrulation. Neutrophil specific knockout mice show defects in inflammatory recruitment and chemotactic responses.
 
Interactions
Rac1 interacts with 234 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (88 annotations)
Process actin cytoskeleton organization, actin filament organization, ...
Component cell projection, cytoplasm, ...
Function enzyme binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (51 records)
Data Summary: Results (178)    Tissues (145)    Images (42)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 20, 21, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 22
RNA in situ 137
Western blot 13
RT-PCR 6
cDNA source data(23)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(23) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000020705 (Evidence)
Ensembl Gene ModelENSMUSG00000001847 (Evidence)
Entrez Gene19353 (Evidence)
Consensus CDS ProjectCCDS19843.1
International Mouse Knockout Project StatusRac1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020705 VEGA Gene Model | MGI Sequence Detail 22559 C57BL/6J ±  kb
transcript OTTMUST00000049001 VEGA | MGI Sequence Detail 2325 Not Applicable 
polypeptide OTTMUSP00000022621 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(140 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003578 Small GTPase superfamily, Rho type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013660 ras-related C3 botulinum toxin substrate 1
References (Earliest) J:724 Moll J, et al., The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments. Oncogene. 1991 May;6(5):863-6
(Latest) J:211642 Wei J, et al., The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8883-8
All references(283)
Other
accession IDs
MGD-MRK-13748, MGI:1261850, MGI:2141016

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory