Rac1
Gene Detail

Symbol Name ID

Rac1 RAS-related C3 botulinum substrate 1 MGI:97845

Synonyms

D5Ertd559e

Feature Type

protein coding gene

Genetic Map

Chromosome 5

82.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr5:143505478-143528036 bp, - strand From VEGA annotation of GRCm38   22559 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69035  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: small GTPase, Rho type
Gene Tree: Rac1

Human homologs

Human Homolog		RAC1, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
NCBI Gene ID		5879
neXtProt AC		NX_P63000
Human Synonyms		p21-Rac1, Rac-1, TC-25
Human Chr (Location)		7p22; chr7:6414126-6443598 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(44) : Targeted(7) Gene trapped(37)
 

Homozygotes for targeted null mutations exhibit embryonic lethality prior to embryonic day 9.5 with defects in gastrulation. Neutrophil specific knockout mice show defects in inflammatory recruitment and chemotactic responses.

 

Gene Ontology (GO) classifications

All GO classifications: (75 annotations)

Process	actin cytoskeleton organization, actin filament organization, ...
Component	cell projection, cytoplasm, ...
Function	enzyme binding, GTPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (47 records)
Data Summary: Results (90)    Tissues (58)    Images (37)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 20, 21, 23, 26, 28

Assay Type	Results
Immunohistochemistry	21
RNA in situ	48
Western blot	9
RT-PCR	12

cDNA source data(22)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(1) cDNA(22) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000020705 (Evidence)
Ensembl Gene Model	ENSMUSG00000001847 (Evidence)
Entrez Gene	19353 (Evidence)
Consensus CDS Project	CCDS19843.1
International Mouse Knockout Project Status	Rac1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020705	VEGA Gene Model | MGI Sequence Detail	22559	C57BL/6J
transcript	OTTMUST00000049001	VEGA | MGI Sequence Detail	2325	Not Applicable
polypeptide	OTTMUSP00000022621	VEGA | MGI Sequence Detail	211	Not Applicable

All sequences(58) RefSeq(2) UniProt(6)

Polymorphisms

SNPs within 2kb(140 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR003578	Small GTPase superfamily, Rho type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000013660	ras-related C3 botulinum toxin substrate 1

References

(Earliest) J:724 Moll J, et al., The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments. Oncogene. 1991 May;6(5):863-6
(Latest) J:196296 Golden SA, et al., Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression. Nat Med. 2013 Mar;19(3):337-44
All references(245)

Other accession IDs

MGD-MRK-13748, MGI:1261850, MGI:2141016