Sequence Detail

ID/Version

P63001 P15154 Q9BTB4 O95501 (UniProt | EBI)

Last sequence update: 2004-08-31
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Ras-related C3 botulinum toxin substrate 1 {ECO:0000305}; EC=3.6.5.2 {ECO:0000269|PubMed:24352656, ECO:0000269|PubMed:26969129};AltName: Full=p21-Rac1;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 192 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rac1	Rac family small GTPase 1	192	134	4	51

Sequence references in MGI

J:724 Moll J, et al., The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments. Oncogene. 1991 May;6(5):863-6
J:63704 Lin D, et al., A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol. 2000 Aug;2(8):540-7
J:69174 Joberty G, et al., The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol. 2000 Aug;2(8):531-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101162 Reddig PJ, et al., Regulation of p21-activated kinase-independent Rac1 signal transduction by nischarin. J Biol Chem. 2005 Sep 2;280(35):30994-1002
J:118168 Cho YJ, et al., Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages. Mol Cell Biol. 2007 Feb;27(3):899-911
J:142252 Shibata S, et al., Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nat Med. 2008 Dec;14(12):1370-6
J:143541 Chen L, et al., Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Dev Biol. 2009 Jan 1;325(1):162-70
J:153892 Guerrier S, et al., The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis. Cell. 2009 Sep 4;138(5):990-1004
J:169711 Wallace SW, et al., The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells. Mol Cell Biol. 2011 Jan;31(1):81-91
J:204642 Li X, et al., Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase. J Biol Chem. 2010 Oct 15;285(42):32436-45
J:205863 Cunningham CA, et al., The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells. Eur J Immunol. 2013 Dec;43(12):3361-71
J:213034 Raynaud F, et al., Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis. J Biol Chem. 2014 Jan 31;289(5):2600-9
J:238439 Sarowar T, et al., Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2. Mol Brain. 2016 Mar 11;9:28
J:261829 Yang T, et al., POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration. Cell Rep. 2012 Sep 27;2(3):640-51
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89