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Pax9
Gene Detail
Symbol

Name
ID
Pax9
paired box 9
MGI:97493
Synonyms
Pax-9
Feature Type
protein coding gene
Genetic Map
Chromosome 12
24.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr12:56691767-56712707 bp, + strand
From VEGA annotation of GRCm38

  20941 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31360  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PAX9
Protein SuperFamily: paired box protein PAX
Gene Tree: Pax9

Human
homologs
PAX9, paired box 9
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5083
neXtProt AC: NX_P55771

Human Synonyms: STHAG3

Human Chr (Location): 14q13.3; chr14:36657568-36677807 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PAX9

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene results in abnormal tooth development and absent teeth and may lead to lack of pharyngeal pouch derivatives, athymia, craniofacial and limb anomalies, a small tympanic ring, various defects of the skeleton and musculature, and neonatal lethality.
 
Human Diseases Modeled in Mice Using Pax9 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Pax9 interacts with 385 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cellular response to growth factor stimulus, endoderm development, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (138 records)
Data Summary: Results (371)    Tissues (202)    Images (120)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 347
In situ reporter (knock in) 2
Northern blot 8
RNase protection 9
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PAX9 ; Xenbase pax9 ; ZFIN pax9    NEW 
Molecular
reagents
All nucleic(26) Genomic(2) cDNA(13) Primer pair(1) Other(10)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000023206 (Evidence)
Ensembl Gene Model ENSMUSG00000001497 (Evidence)
Entrez Gene 18511 (Evidence)
NIA Mouse Gene Index U013975
Consensus CDS Project CCDS25924.1
International Mouse Phenotyping Consortium Status Pax9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023206 VEGA Gene Model | MGI Sequence Detail 20941 C57BL/6J ±  kb
transcript OTTMUST00000056158 VEGA | MGI Sequence Detail 4232 Not Applicable 
polypeptide OTTMUSP00000026953 VEGA | MGI Sequence Detail 342 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(14) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(160 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009057 Homeodomain-like
InterPro IPR001523 Paired domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000012321 paired box protein Pax-9
References
(Earliest) J:4336 Stapleton P, et al., Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9. Nat Genet. 1993 Apr;3(4):292-8
(Latest) J:219797 Ranghini EJ, et al., Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms. Dev Biol. 2015 Mar 15;399(2):296-305
All references(176)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13152, MGD-MRK-13161

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory