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Phenotypes Associated with This Genotype
Genotype
MGI:3612954
Allelic
Composition
Pax9tm1Hpt/Pax9tm1Hpt
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax9tm1Hpt mutation (0 available); any Pax9 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• in 13% of mice all teeth are present but the lower incisors and third molars are hypoplastic
• in 35% of mice tooth defects differ between the right and left halves of the lower jaw
• the lower first molars show significant attrition and formation of reparative and reactionary dentin
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed
• lower third molars and incisors may fail to erupt
• a mixture of reactionary and reparative dentin seen in molars
• the lower first molars show significant attrition
• in 35% of mice up to 3 teeth are absent (hypodontia) and in 52% of mice 4 or more teeth are absent (oligodontia); however the secondary palate is intact and digit duplication is not seen
• in most cases the lower incisors are absent
• the upper and lower third molars are unilaterally or bilaterally absent

skeleton
• in 13% of mice all teeth are present but the lower incisors and third molars are hypoplastic
• in 35% of mice tooth defects differ between the right and left halves of the lower jaw
• the lower first molars show significant attrition and formation of reparative and reactionary dentin
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed
• lower third molars and incisors may fail to erupt
• a mixture of reactionary and reparative dentin seen in molars
• the lower first molars show significant attrition
• in 35% of mice up to 3 teeth are absent (hypodontia) and in 52% of mice 4 or more teeth are absent (oligodontia); however the secondary palate is intact and digit duplication is not seen
• in most cases the lower incisors are absent
• the upper and lower third molars are unilaterally or bilaterally absent

endocrine/exocrine glands
N
• thymus morphology is normal and no signs of defective parathyroid or ultimobranchial body function (as shown by normal calcium and phosphate homeostasis) are seen

growth/size/body
• in 13% of mice all teeth are present but the lower incisors and third molars are hypoplastic
• in 35% of mice tooth defects differ between the right and left halves of the lower jaw
• the lower first molars show significant attrition and formation of reparative and reactionary dentin
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed
• lower third molars and incisors may fail to erupt
• a mixture of reactionary and reparative dentin seen in molars
• the lower first molars show significant attrition
• in 35% of mice up to 3 teeth are absent (hypodontia) and in 52% of mice 4 or more teeth are absent (oligodontia); however the secondary palate is intact and digit duplication is not seen
• in most cases the lower incisors are absent
• the upper and lower third molars are unilaterally or bilaterally absent


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory