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Pax9tm1Rbal
Targeted Allele Detail
Summary
Symbol: Pax9tm1Rbal
Name: paired box 9; targeted mutation 1, R Balling
MGI ID: MGI:1857887
Synonyms: Pax9lacZ
Gene: Pax9  Location: Chr12:56738552-56759607 bp, + strand  Genetic Position: Chr12, 24.53 cM
Alliance: Pax9tm1Rbal page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49857
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe endogenous start codon as well as the exon encoding the paired box was replaced a LacZ and PGK-neomycin based cassette. Lack of wild-type protein was confirmed by Western analysis in homozygous mutant embryos. (J:49857)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 114 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 33 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pax9 Mutation:  16 strains or lines available
References
Original:  J:49857 Peters H, et al., Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev. 1998 Sep 1;12(17):2735-47
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory