Pax9^tm1Rbal
Targeted Allele Detail

Summary

• Symbol: Pax9^tm1Rbal
• Name: paired box 9; targeted mutation 1, R Balling
• MGI ID: MGI:1857887
• Synonyms: Pax9^lacZ
• Gene: Pax9 Location: Chr12:56738552-56759607 bp, + strand Genetic Position: Chr12, 24.53 cM
• Alliance: Pax9^tm1Rbal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49857
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous start codon as well as the exon encoding the paired box was replaced a LacZ and PGK-neomycin based cassette. Lack of wild-type protein was confirmed by Western analysis in homozygous mutant embryos. (J:49857)

Disease models

Expression

In Mice Carrying this Mutation:	114 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	33 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax9 Mutation: 16 strains or lines available

References

• Original: J:49857 Peters H, et al., Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev. 1998 Sep 1;12(17):2735-47
• All: 17 reference(s)