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Phenotypes Associated with This Genotype
Genotype
MGI:3612955
Allelic
Composition
Pax9tm1Hpt/Pax9tm1Rbal
Genetic
Background
involves: 129 * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax9tm1Hpt mutation (0 available); any Pax9 mutation (16 available)
Pax9tm1Rbal mutation (0 available); any Pax9 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• underrepresented at weaning

craniofacial
• the lower first molars show significant attrition and formation of reparative dentin
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed
• irregular dentin formation is indicated by the presence of 'contour lines of Owen'
• in the upper incisors ameloblasts are present at 2 months of age but absent by 5 months
• in the upper incisors ameloblasts fail to elongate and produce only a thin layer of pre-enamel
• lower third molars and incisors fail to erupt and other teeth in the lower jaw may also fail to erupt
• at P0 all third molars are arrested prior to the bud stage and the lower second molars are arrested at the bud stage
• at P0 the lower first molars have reached the bell stage but lack polarization and alignment of the ameloblasts and odontoblasts
• at P0 the upper first and second molars are mostly growth retarded
• the upper incisors lack enamel; however enamel formation in the molars is normal
• the lower first molars show significant attrition
• more severe tooth loss than in Pax9tm1Hpt homozygotes with all mice lacking at least 4 teeth (oligodontia) and some lacking all lower teeth
• all mice lack lower incisors
• the upper third and lower second and third molars are unilaterally or bilaterally absent

growth/size/body
• the lower first molars show significant attrition and formation of reparative dentin
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed
• irregular dentin formation is indicated by the presence of 'contour lines of Owen'
• in the upper incisors ameloblasts are present at 2 months of age but absent by 5 months
• in the upper incisors ameloblasts fail to elongate and produce only a thin layer of pre-enamel
• lower third molars and incisors fail to erupt and other teeth in the lower jaw may also fail to erupt
• at P0 all third molars are arrested prior to the bud stage and the lower second molars are arrested at the bud stage
• at P0 the lower first molars have reached the bell stage but lack polarization and alignment of the ameloblasts and odontoblasts
• at P0 the upper first and second molars are mostly growth retarded
• the upper incisors lack enamel; however enamel formation in the molars is normal
• the lower first molars show significant attrition
• more severe tooth loss than in Pax9tm1Hpt homozygotes with all mice lacking at least 4 teeth (oligodontia) and some lacking all lower teeth
• all mice lack lower incisors
• the upper third and lower second and third molars are unilaterally or bilaterally absent

skeleton
• the lower first molars show significant attrition and formation of reparative dentin
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed
• irregular dentin formation is indicated by the presence of 'contour lines of Owen'
• in the upper incisors ameloblasts are present at 2 months of age but absent by 5 months
• in the upper incisors ameloblasts fail to elongate and produce only a thin layer of pre-enamel
• lower third molars and incisors fail to erupt and other teeth in the lower jaw may also fail to erupt
• at P0 all third molars are arrested prior to the bud stage and the lower second molars are arrested at the bud stage
• at P0 the lower first molars have reached the bell stage but lack polarization and alignment of the ameloblasts and odontoblasts
• at P0 the upper first and second molars are mostly growth retarded
• the upper incisors lack enamel; however enamel formation in the molars is normal
• the lower first molars show significant attrition
• more severe tooth loss than in Pax9tm1Hpt homozygotes with all mice lacking at least 4 teeth (oligodontia) and some lacking all lower teeth
• all mice lack lower incisors
• the upper third and lower second and third molars are unilaterally or bilaterally absent

endocrine/exocrine glands
N
• thymus morphology is normal and no signs of defective parathyroid or ultimobranchial body function (as shown by normal calcium and phosphate homeostasis) are seen


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory